Zu "K04718" wurden 104 Artikel gefunden!
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Sphingosine Kinase 1 Inhibitor Screening Assay Kit Artikelnummer: Cay701740-96
Cayman's SPHK1 Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human SPHK1, an enzyme implicated in the control of diverse biological functions including cell proliferation, survival and differentiation, cell migration and tissue invasion, and angiogenesis...
| Schlagworte: | SK1, SPHK1 |
| Anwendung: | Fluorometric human SPHK1 inhibitor screening |
| Reaktivität: | Human |
494,00 €
Anti-SPHK2 Artikelnummer: E-AB-67567.120
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis...
| Schlagworte: | Anti-SK2, Anti-SK 2, Anti-SPK 2, Anti-Sphingosine kinase 2, SPHK2 Polyclonal Antibody |
| Anwendung: | WB |
| Reaktivität: | Human, Mouse |
ab 208,00 €
SPHK1 Assay Kit Artikelnummer: BPS-78026
The SPHK1 Assay Kit is designed to measure SPHK1 activity for screening and profiling applications using Kinase-Glo(R) MAX as a detection reagent.
| Schlagworte: | SK 1, SPK 1, EC=2.3.1.-, Sphingosine kinase 1, Acetyltransferase SPHK1 |
| Anwendung: | Enzyme kinetics, Drug discovery, HTS |
| Reaktivität: | Human |
675,00 €
Anti-SPHK1 Artikelnummer: NSJ-F50217-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell...
| Schlagworte: | Anti-SK 1, Anti-SPK 1, EC=2.3.1.-, Anti-Sphingosine kinase 1, Anti-Acetyltransferase SPHK1, SPHK1 Antibody |
| Anwendung: | WB, IHC, ELISA |
| Reaktivität: | Human, Mouse, Rat, Primate |
ab 228,00 €
Anti-SPHK2 Artikelnummer: NSJ-F50220-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell...
| Schlagworte: | Anti-SK2, Anti-SK 2, Anti-SPK 2, Anti-Sphingosine kinase 2, SPHK2 Antibody |
| Anwendung: | IHC, WB, ELISA |
| Reaktivität: | Human |
ab 228,00 €
Sphingosine Kinase Inhibitor 2 Artikelnummer: Cay10009222-5
Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Sphingosine kinase inhibitor 2 is an...
| Schlagworte: | SKI II, SPHK I2, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol |
| Anwendung: | SPHK1 inhibitor |
| CAS | 312636-16-1 |
| MW: | 302.8 D |
ab 40,00 €
N,N-Dimethylsphingosine Artikelnummer: Cay62575-5
N,N-Dimethylsphingosine is a metabolite of sphingosine and an inhibitor of sphingosine kinase (SPHK) with Ki values of 3.1, 6.8, and 2.3 µM in U937, PC12, and Swiss 3T3 cell extracts, respectively. It is selective for SPHK over PKC in PC12 cells when used at a concentration of 10 µM. Formal Name:...
| Schlagworte: | 2S-(dimethylamino)-4E-octadecene-1,3R-diol |
| Anwendung: | Sphingosine kinase inhibitor |
| CAS | 119567-63-4 |
| MW: | 327.6 D |
ab 70,00 €
CAY10621 Artikelnummer: Cay13371-1
CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM. Formal Name:...
| Schlagworte: | SKI 5C, SPHK1 Inhibitor 5C, (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl... |
| Anwendung: | SPHK 1 inhibitor |
| CAS | 120005-55-2 |
| MW: | 435.6 D |
ab 27,00 €
PF-543 Artikelnummer: Cay17034-1
PF-543 is a potent inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 2 nM) that inhibits sphingosine-1-phosphate (S1P) binding to human recombinant SPHK1 (Ki = 3.6 nM). It is selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at a concentration of 10 µM....
| Schlagworte: | 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2R-pyrrolidinemethanol, monohydrochloride |
| Anwendung: | Sphingosine kinase 1 inhibitor |
| CAS | 1706522-79-3 |
| MW: | 502.1 D |
ab 32,00 €
D-Sphingosine Artikelnummer: LKT-S6129.5
Induces apoptosis by inhibiting protein kinase. It is also reported to cause inhibition of adrenaline stimulated cyclic AMP accumulation, permeation of cells and making them leaky to ATP, inhibition of adrenaline-stimulated adenylate cyclase inhibition of cyclic AMP.
| Schlagworte: | 4-Sphingenine |
| Anwendung: | Kinase inhibitor |
| CAS | 123-78-4 |
| MW: | 299,49 D |
ab 141,00 €
Sphingosine Kinase 1 (human recombinant) Artikelnummer: Cay10348-25
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells. Among them, SPHK1 has been implicated to...
| Schlagworte: | SK 1, SK 1, SPK 1, SPK 1, Sphingosine kinase 1, Sphingosine kinase 1, Acetyltransferase SPHK1, Acetyltransferase SPHK1 |
| Anwendung: | Enzyme activity |
| MW: | 47,5 kD |
438,00 €
Anti-SPHK1 Artikelnummer: ARG55846.100
Protein function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine,...
| Schlagworte: | Anti-SPHK, Anti-SK 1, Anti-SPK 1, Anti-SPHK1, EC=2.7.1.91, Anti-Sphingosine kinase 1 |
| Anwendung: | IHC (paraffin), WB |
| Reaktivität: | Human, Mouse |
474,00 €