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Sphingosine Kinase 1 Inhibitor Screening Assay Kit
Sphingosine Kinase 1 Inhibitor Screening Assay Kit

Artikelnummer: Cay701740-96

Cayman's SPHK1 Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human SPHK1, an enzyme implicated in the control of diverse biological functions including cell proliferation, survival and differentiation, cell migration and tissue invasion, and angiogenesis...
Schlagworte: SK1, SPHK1
Anwendung: Fluorometric human SPHK1 inhibitor screening
Reaktivität: Human
494,00 €
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Anti-SPHK2
Anti-SPHK2

Artikelnummer: E-AB-67567.120

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis...
Schlagworte: Anti-SK2, Anti-SK 2, Anti-SPK 2, Anti-Sphingosine kinase 2, SPHK2 Polyclonal Antibody
Anwendung: WB
Reaktivität: Human, Mouse
ab 208,00 €
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SPHK1 Assay Kit
SPHK1 Assay Kit

Artikelnummer: BPS-78026

The SPHK1 Assay Kit is designed to measure SPHK1 activity for screening and profiling applications using Kinase-Glo(R) MAX as a detection reagent.
Schlagworte: SK 1, SPK 1, EC=2.3.1.-, Sphingosine kinase 1, Acetyltransferase SPHK1
Anwendung: Enzyme kinetics, Drug discovery, HTS
Reaktivität: Human
675,00 €
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Anti-SPHK1
Anti-SPHK1

Artikelnummer: NSJ-F50217-0.05ML

In 1X PBS, pH 7.4, with 0.09% sodium azide. Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell...
Schlagworte: Anti-SK 1, Anti-SPK 1, EC=2.3.1.-, Anti-Sphingosine kinase 1, Anti-Acetyltransferase SPHK1, SPHK1 Antibody
Anwendung: WB, IHC, ELISA
Reaktivität: Human, Mouse, Rat, Primate
ab 228,00 €
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Anti-SPHK2
Anti-SPHK2

Artikelnummer: NSJ-F50220-0.05ML

In 1X PBS, pH 7.4, with 0.09% sodium azide. Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell...
Schlagworte: Anti-SK2, Anti-SK 2, Anti-SPK 2, Anti-Sphingosine kinase 2, SPHK2 Antibody
Anwendung: IHC, WB, ELISA
Reaktivität: Human
ab 228,00 €
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Sphingosine Kinase Inhibitor 2
Sphingosine Kinase Inhibitor 2

Artikelnummer: Cay10009222-5

Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Sphingosine kinase inhibitor 2 is an...
Schlagworte: SKI II, SPHK I2, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol
Anwendung: SPHK1 inhibitor
CAS 312636-16-1
MW: 302.8 D
ab 40,00 €
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N,N-Dimethylsphingosine
N,N-Dimethylsphingosine

Artikelnummer: Cay62575-5

N,N-Dimethylsphingosine is a metabolite of sphingosine and an inhibitor of sphingosine kinase (SPHK) with Ki values of 3.1, 6.8, and 2.3 µM in U937, PC12, and Swiss 3T3 cell extracts, respectively. It is selective for SPHK over PKC in PC12 cells when used at a concentration of 10 µM. Formal Name:...
Schlagworte: 2S-(dimethylamino)-4E-octadecene-1,3R-diol
Anwendung: Sphingosine kinase inhibitor
CAS 119567-63-4
MW: 327.6 D
ab 70,00 €
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CAY10621
CAY10621

Artikelnummer: Cay13371-1

CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM. Formal Name:...
Schlagworte: SKI 5C, SPHK1 Inhibitor 5C, (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl...
Anwendung: SPHK 1 inhibitor
CAS 120005-55-2
MW: 435.6 D
ab 27,00 €
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PF-543
PF-543

Artikelnummer: Cay17034-1

PF-543 is a potent inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 2 nM) that inhibits sphingosine-1-phosphate (S1P) binding to human recombinant SPHK1 (Ki = 3.6 nM). It is selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at a concentration of 10 µM....
Schlagworte: 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2R-pyrrolidinemethanol, monohydrochloride
Anwendung: Sphingosine kinase 1 inhibitor
CAS 1706522-79-3
MW: 502.1 D
ab 32,00 €
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D-Sphingosine
D-Sphingosine

Artikelnummer: LKT-S6129.5

Induces apoptosis by inhibiting protein kinase. It is also reported to cause inhibition of adrenaline stimulated cyclic AMP accumulation, permeation of cells and making them leaky to ATP, inhibition of adrenaline-stimulated adenylate cyclase inhibition of cyclic AMP.
Schlagworte: 4-Sphingenine
Anwendung: Kinase inhibitor
CAS 123-78-4
MW: 299,49 D
ab 141,00 €
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Sphingosine Kinase 1 (human recombinant)
Sphingosine Kinase 1 (human recombinant)

Artikelnummer: Cay10348-25

Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells. Among them, SPHK1 has been implicated to...
Schlagworte: SK 1, SK 1, SPK 1, SPK 1, Sphingosine kinase 1, Sphingosine kinase 1, Acetyltransferase SPHK1, Acetyltransferase SPHK1
Anwendung: Enzyme activity
MW: 47,5 kD
438,00 €
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Anti-SPHK1
Anti-SPHK1

Artikelnummer: ARG55846.100

Protein function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine,...
Schlagworte: Anti-SPHK, Anti-SK 1, Anti-SPK 1, Anti-SPHK1, EC=2.7.1.91, Anti-Sphingosine kinase 1
Anwendung: IHC (paraffin), WB
Reaktivität: Human, Mouse
474,00 €
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