Zu "K04702" wurden 83 Artikel gefunden!
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TCS PIM-1 1
Artikelnummer: TGM-T2253-1mg
Description: TCS PIM-1 1 (SC 204330)(sc-204330) is an effective and specific ATP-competitive Pim-1 kinase inhibitor (IC50: 50 nM), exhibiting good specificity over MEK1/MEK2 and Pim-2 (IC50s > 20,000 nM). Target: Pim. Smiles: Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
| Schlagworte: | SC 204330 |
| Anwendung: | PIM1 inhibitor |
| CAS | 491871-58-0 |
| MW: | 367.2 D |
ab 30,00 €
CX-6258
Artikelnummer: Cay16245-1
The family of Pim (Provirus Integration site for Moloney murine leukemia virus) proteins are serine/threonine kinases involved in cell survival and cell proliferation. CX-6258 is a potent, reversible inhibitor of Pim-1, -2, and -3 (IC50s = 5, 25, and 16 nM, respectively). It demonstrates excellent selectivity,...
| Schlagworte: | Pim-Kinase Inhibitor X,... |
| Anwendung: | Pim kinase inhibitor |
| CAS | 1202916-90-2 |
| MW: | 461.9 D |
ab 76,00 €
SMI-4a
Artikelnummer: Cay11029-5
The serine/threonine Pim kinases have been suggested to promote the activity of the rapamycin-sensitive mammalian target of rapamycin (mTORC1), which regulates cell growth and survival. Pim kinases are overexpressed in solid cancers and hematologic malignancies, and as such have become targets of small molecule...
| Schlagworte: | 5Z-[[3-(trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| Anwendung: | Pim-1/Pim-2 kinase inhibitor |
| CAS | 438190-29-5 |
| MW: | 273.2 D |
ab 69,00 €
SGI-1776
Artikelnummer: Cay16423-1
The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little...
| Schlagworte: | Pim-Kinase Inhibitor IX, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine |
| Anwendung: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405.4 D |
ab 51,00 €
SMI-4a
Artikelnummer: AG-CR1-3503-M005
Selective inhibitor of Pim-1 and Pim-2 protein kinases, Inducer of G1 phase cell cycle arrest, Inducer of p27Kip1, Inducer of apoptosis through the mitochondrial pathway, Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway, Downregulates c-myc, Inhibitor of PRAS40 phosphorylation and mTOR activity,...
| Schlagworte: | (5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| Anwendung: | Pim-1/Pim-2 kinase inhibitor |
| CAS | 327033-36-3 |
| MW: | 273,2 D |
99,00 €
AZD 1208
Artikelnummer: Cay20235-5
AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively). It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16...
| Schlagworte: | (5Z)-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione |
| Anwendung: | Pim-1 / Pim-2 / Pim-3 inhibitor |
| CAS | 1204144-28-4 |
| MW: | 379.5 D |
ab 51,00 €
AZD1208
Artikelnummer: SYN-1214-M010
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3...
| Schlagworte: | AZD-1208 |
| Anwendung: | Potent, highly selective Pim kinase inhibitor |
ab 92,00 €
Anti-PIM-1
Artikelnummer: ARG53469.500
Protein function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by...
| Schlagworte: | Anti-PIM1, EC=2.7.11.1, Anti-Serine/threonine-protein kinase pim-1 |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
625,00 €
PIM1, Active, GST-tag
Artikelnummer: BPS-41107
Recombinant human serine/threonine-protein kinase PIM1 (PIM1), GenBank Accession No. NM_002648, full-length with an N-terminal GST tag and expressed in a baculovirusinfected Sf9 insect cell expression system. MW = 62 kDa.
| Schlagworte: | PIM1, Serine/threonine-protein kinase pim-1, |
| Anwendung: | Studying enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 62 kD |
901,00 €
SMI-4a
Artikelnummer: LKT-S4932.10
Thiazolidine, Pim kinase inhibitor.
| Anwendung: | Thiazolidine, Pim kinase inhibitor |
| CAS | 438190-29-5 |
| MW: | 273.23 D |
ab 116,00 €
Anti-PIM-1
Artikelnummer: NSJ-R31728
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Proto-oncogene serine/threonine-protein kinase PIM-1 is an enzyme that in humans is encoded by the PIM1 gene. It is mapped to 6p21.2. Primarily expressed in spleen, thymus, bone marrow, prostate, oral epithelial, hippocampus and fetal liver cells, It has also...
| Schlagworte: | Anti-PIM1, EC=2.7.11.1, Anti-Serine/threonine-protein kinase pim-1, PIM-1 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
SMI-4a
Artikelnummer: BPS-27774-1
SMI-4a is a potent inhibitor of Pim1 with IC50 = 17 -21 nM. It does not significantly inhibit other serine/threonine- or tyrosine-kinases. It induces G1 phase cell cycle arrest and induces apoptosis through the mitocondrial pathway. It downregulates c-myc and induces p27Kip1 expression. Inhibits PRAS40...
| Schlagworte: | 5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione, |
| Anwendung: | PIM1 inhibitor |
| MW: | 273.2 D |
ab 357,00 €