Zu "K04678" wurden 67 Artikel gefunden!
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Heclin
Artikelnummer: Cay26139-1
Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 µM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively). It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 µM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing...
| Schlagworte: | N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide |
| Anwendung: | HECT-type E3 ubiquitin ligase inhibitor |
| CAS | 890605-54-6 |
| MW: | 283.3 D |
ab 51,00 €
Anti-SOCS1
Artikelnummer: 600-401-ES0
Anti-SOCS1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with SOCS1 from other sources has not been determined. Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and...
| Schlagworte: | Anti-SMURF2, Anti-hSMURF2, EC=6.3.2.-, Anti-E3 ubiquitin-protein ligase SMURF2, Anti-SMAD ubiquitination regulatory factor... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
848,00 €
SMURF1 intrachain TR-FRET Assay Kit
Artikelnummer: BPS-78303
Covalent conjugation to ubiquitin (Ub) is one of the major post-translational modifications that regulates protein stability, function, and localization. Ubiquitination is the concerted action of three enzymes: a Ub-activating enzyme (E1), a Ub-conjugating enzyme (E2), and a Ub ligase (E3). The specificity and...
| Schlagworte: | SMAD specific E3 ubiquitin protein ligase 1, SMURF1, TR-FRET Kit, Homogeneous Kit, |
| Anwendung: | Small molecule screening, drug discovery, HTS, kinetics |
| Spezies-Reaktivität: | human |
2.298,00 €
SMURF2 intrachain TR-FRET Assay Kit
Artikelnummer: BPS-78304
Covalent conjugation to ubiquitin (Ub) is one of the major post-translational modifications that regulates protein stability, function, and localization. Ubiquitination is the concerted action of three enzymes: a Ub-activating enzyme (E1), a Ub-conjugating enzyme (E2), and a Ub ligase (E3). The specificity and...
| Schlagworte: | SMAD specific E3 ubiquitin protein ligase 2, SMURF2, TR-FRET Kit, Homogeneous Kit, |
| Anwendung: | Small molecule screening, drug discovery, HTS, kinetics |
| Spezies-Reaktivität: | human |
2.298,00 €
SMURF1, active human recombinant protein
Artikelnummer: BPS-80402
Human SMURF 1 (GenBank Accession No. NM_020429), amino-acids 150-end, with N-terminal DDDDK tag (FLAG) MW= 70 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
| Schlagworte: | SMURF1, hSMURF1, KIAA1625, E3 ubiquitin-protein ligase SMURF1, SMAD ubiquitination regulatory factor 1, HECT-type E3... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 70 kD |
588,00 €
SMURF2, active human recombinant protein
Artikelnummer: BPS-80403
Human SMURF 2 (GenBank Accession No. NM_022739), amino-acids 130-end, with N-terminal DDDDK tag (FLAG), MW= 72 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
| Schlagworte: | hSMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, HECT-type E3 ubiquitin transferase... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 72 kD |
603,00 €
Anti-SnoN
Artikelnummer: 600-401-ER9
Anti-SnoN Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with SnoN from other sources has not been determined. Protein function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and...
| Schlagworte: | Anti-SMURF1, Anti-hSMURF1, Anti-KIAA1625, EC=6.3.2.-, Anti-E3 ubiquitin-protein ligase SMURF1, Anti-SMAD ubiquitination... |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
Anti-SMURF2
Artikelnummer: NSJ-R32322
0.5mg/ml if reconstituted with 0.2ml sterile DI water. E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. The SMURF2 gene is mapped to chromosome 17q22-q23 based on sequence similarity between the SMURF2 sequence and a genomic contig. SMURF2 is a HECT domain E3 ubiquitin...
| Schlagworte: | Anti-SMURF2, Anti-hSMURF2, EC=6.3.2.-, Anti-E3 ubiquitin-protein ligase SMURF2, Anti-SMAD ubiquitination regulatory factor... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-SMURF1
Artikelnummer: NSJ-R32324
0.5mg/ml if reconstituted with 0.2ml sterile DI water. E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. It is mapped to 7q22.1. This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This...
| Schlagworte: | Anti-SMURF1, Anti-hSMURF1, Anti-KIAA1625, EC=6.3.2.-, Anti-E3 ubiquitin-protein ligase SMURF1, Anti-SMAD ubiquitination... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
790,00 €
Anti-SMURF1
Artikelnummer: ARG59465.50
Protein function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and...
| Schlagworte: | Anti-SMURF1, Anti-hSMURF1, Anti-KIAA1625, Anti-E3 ubiquitin-protein ligase SMURF1, Anti-SMAD ubiquitination regulatory... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
551,00 €
Anti-SMURF2
Artikelnummer: ARG59482.100
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In...
| Schlagworte: | Anti-SMURF2, Anti-hSMURF2, Anti-E3 ubiquitin-protein ligase SMURF2, Anti-SMAD ubiquitination regulatory factor 2,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
658,00 €
A01
Artikelnummer: Cay26137-10
A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM). It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 µM)...
| Schlagworte: | [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-methanone |
| Anwendung: | Smurf1 inhibitor |
| CAS | 1007647-73-5 |
| MW: | 512.9 D |
ab 149,00 €