Zu "K04675" wurden 89 Artikel gefunden!
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Anti-ACVR1 / ALK2 Biotin Conjugate
Artikelnummer: NSJ-R35649BTN
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Activin A receptor, type I alpha, ALK2, Activin receptor-like kinase 2
| Schlagworte: | Anti-ACVR1, Anti-Activin receptor type I, Anti-Activin receptor type-1, Anti-Activin receptor-like kinase 2, Anti-TGF-B... |
| Anwendung: | WB, IHC, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
ALK2 Extracellular Domain (human, recombinant)
Artikelnummer: Cay44183-1
Activin receptor-like kinase 2 (ALK2) is a type I receptor kinase and member of the bone morphogenetic protein (BMP) receptor family. It is composed of a ligand-binding extracellular domain, a transmembrane domain, a membrane-associated glycine/serine-rich (GS) domain, and an intracellular kinase domain. ALK2 is...
| Schlagworte: | Activin Receptor Type I, Activin Receptor-like Kinase 2, ACTR-I, ACVR1, Serine/threonine-protein Kinase Receptor R1,... |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
ab 402,00 €
DMH1
Artikelnummer: Cay16679-10
Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin (Cay-11967) that potently inhibits the kinase activity of activin receptor-like...
| Schlagworte: | BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482, 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | ALK2 inhibitor |
| CAS | 1206711-16-1 |
| MW: | 380.4 D |
ab 60,00 €
LDN-193189 (hydrochloride)
Artikelnummer: Cay19396-1
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over...
| Schlagworte: | DM-3189, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride |
| Anwendung: | ALK1 / ALK2 / ALK3 / ALK6 inhibitor |
| CAS | 1435934-00-1 |
| MW: | 479.4 D |
ab 41,00 €
LDN-193189
Artikelnummer: Cay11802-10
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...
| Schlagworte: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.5 D |
ab 45,00 €
K02288
Artikelnummer: Cay16678-10
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based...
| Schlagworte: | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1431985-92-0 |
| MW: | 352.4 D |
ab 56,00 €
LDN-212854
Artikelnummer: Cay17698-1
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. LDN-212854 inhibits ALK2 (IC50 =...
| Schlagworte: | 5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | ALK2 inhibitor |
| CAS | 1432597-26-6 |
| MW: | 406.5 D |
ab 54,00 €
LDN-214117
Artikelnummer: Cay18006-1
Bone morphogenetic proteins (BMPs) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. Activation of BMP type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the...
| Schlagworte: | 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-piperazine |
| Anwendung: | ALK2 inhibitor |
| CAS | 1627503-67-6 |
| MW: | 419.5 D |
ab 49,00 €
Anti-ACVR1
Artikelnummer: ARG64410.100
Protein function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be...
| Schlagworte: | Anti-SKR1, Anti-ACVR1, Anti-TSR-I, Anti-ALK-2, Anti-ACTR-I, Anti-ACVRLK2, EC=2.7.11.30, Anti-Activin receptor type-1,... |
| Anwendung: | ELISA, IHC (paraffin), WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
ab 598,00 €
ALK2 (ACVR1), GST-tag Recombinant
Artikelnummer: BPS-40019
Recombinant human activin receptor-like kinase 2, or ALK2 (a.a. 147-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_001105.
| Schlagworte: | SKR1, ALK-2, ACVR1, TSR-I, ACTR-I, ACVRLK2, Activin receptor type-1, Activin receptor type I, Activin receptor-like kinase... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 67 kD |
588,00 €
Anti-ACVR1
Artikelnummer: 600-401-X66
Anti-ACVR1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least four isoforms of ACVR1 are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1B or ACVR1C. Protein function: On ligand binding, forms a receptor complex consisting of two type...
| Schlagworte: | Anti-SKR1, Anti-ALK-2, Anti-TSR-I, Anti-ACVR1, Anti-ACTR-I, Anti-ACVRLK2, EC=2.7.11.30, Anti-Activin receptor type I,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
848,00 €
Anti-ACVR1B
Artikelnummer: 600-401-X67
Anti-ACVR1B Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C. Protein function: On ligand binding, forms a receptor complex consisting of two...
| Schlagworte: | Anti-SKR1, Anti-ALK-2, Anti-TSR-I, Anti-ACVR1, Anti-ACTR-I, Anti-ACVRLK2, EC=2.7.11.30, Anti-Activin receptor type I,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
848,00 €