Zu "K04527" wurden 171 Artikel gefunden!
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Insulin degludec
Artikelnummer: Cay46122-1
Insulin degludec is a derivative of insulin that lacks the ThrB30 residue and is acylated at the LysB29 residue with hexadecanedioic acid via a gamma-L-glutamic acid linker. It binds insulin receptors in CHO cell plasma membrane preparations (IC50 = 20 nM). Insulin degludec increases the level of phosphorylated Akt...
| Schlagworte: | IDeg, 29B-[N6-[N-(15-carboxy-1 oxopentadecyl)-L-gamma-glutamyl]-L-lysine]-(1A-21A),(1B-29B)-insulin (human) |
| Anwendung: | Insulin derivative, insulin receptor agonist |
| CAS | 844439-96-9 |
| MW: | 6104.04 D |
ab 83,00 €
Anti-Human Insulin Receptor Antibody Pair
Artikelnummer: ABS-ES-1959.1
Product Description: Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular alpha-subunits, responsible for insulin binding,...
| Schlagworte: | Anti-INSR, Anti-Insulin receptor, Human Insulin Receptor Antibody Pair |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
Anti-Human Insulin Receptor Antibody Pair
Artikelnummer: ABS-ES-1960.1
Product Description: Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular alpha-subunits, responsible for insulin binding,...
| Schlagworte: | Anti-INSR, Anti-Insulin receptor, Human Insulin Receptor Antibody Pair |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
Anti-Human Insulin Receptor Antibody Pair
Artikelnummer: ABS-ES-1958.1
Product Description: Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular alpha-subunits, responsible for insulin binding,...
| Schlagworte: | Anti-INSR, Anti-Insulin receptor, Human Insulin Receptor Antibody Pair |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
Insulin Receptor Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPY-07214-100ug
Description: Insulin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is P15208.
| Schlagworte: | IR-B , CD220 , IR , Insr , IR-A , 4932439J01Rik , D630014A15Rik |
| MW: | 106.44 kD |
ab 80,00 €
Anti-Recombinant Phospho-IGF1R...
Artikelnummer: E-AN301299L.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | Anti-INSR, Anti-Insulin receptor, Recombinant Phospho-IGF1R (Tyr1135/1136)/Phospho-Insulin Receptor beta (Tyr1150/1151)... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
389,00 €
H-Asn-Pro-Glu-Tyr(PO3H2)-OH
Artikelnummer: Cay44048-1
H-Asn-Pro-Glu-Tyr(PO3H2)-OH is a phosphorylated peptide derivative of the tetramine motif Asn-Pro-Glu-Tyr (NPEY), which is found in the insulin receptor beta (InsRbeta) submembrane domain and is phosphorylated at Tyr972 upon insulin binding. InChI:...
| Schlagworte: | Asn-Pro-Glu-Tyr(PO3H2)-OH, L-asparaginyl-L-prolyl-L-alpha-glutamyl-L-tyrosine, dihydrogen phosphate (ester) |
| Anwendung: | InsRbeta submembrane domain NPEY phosphorylated peptide derivative |
| CAS | 290810-63-8 |
| MW: | 601.51 D |
ab 103,00 €
Linsitinib
Artikelnummer: Cay17708-1
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
| Schlagworte: | OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol |
| Anwendung: | IGF-1R & InsR kinase inhibitor |
| CAS | 867160-71-2 |
| MW: | 421.5 D |
ab 62,00 €
INSRb Reporter Assay System (human)
Artikelnummer: IB-IB28001
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | INSR, EC=2.7.10.1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
1.588,00 €
bpV(phen)
Artikelnummer: AG-CR1-0042-M005
Potent protein phosphotyrosine phosphatase inhibitor Insulin receptor kinase (IRK) inducer, Insulin mimetic in vitro and in vivo, Apoptosis inducer, ERK inducer, Mitogen-activated protein kinase phosphatase-1 (MKP-1) inducer, Angiogenesis inhibitor.
| Schlagworte: | Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V) |
| Anwendung: | PTP inhibitor, IRK inducer |
| MW: | 350,2 D |
ab 55,00 €
Anti-Insulin Receptor Beta
Artikelnummer: A303-712A
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | Anti-INSR, EC=2.7.10.1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
BMS 754807
Artikelnummer: Cay17505-10
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
| Schlagworte: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
| Anwendung: | IGF-1R / InsR inhibitor |
| CAS | 1001350-96-4 |
| MW: | 461.5 D |
ab 69,00 €