Zu "K04527" wurden 141 Artikel gefunden!
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Anti-Recombinant Phospho-IGF1R...
Artikelnummer: E-AN301299L.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | Anti-INSR, Anti-Insulin receptor, Recombinant Phospho-IGF1R (Tyr1135/1136)/Phospho-Insulin Receptor beta (Tyr1150/1151)... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
391,00 €
H-Asn-Pro-Glu-Tyr(PO3H2)-OH
Artikelnummer: Cay44048-1
H-Asn-Pro-Glu-Tyr(PO3H2)-OH is a phosphorylated peptide derivative of the tetramine motif Asn-Pro-Glu-Tyr (NPEY), which is found in the insulin receptor beta (InsRbeta) submembrane domain and is phosphorylated at Tyr972 upon insulin binding. InChI:...
| Schlagworte: | Asn-Pro-Glu-Tyr(PO3H2)-OH, L-asparaginyl-L-prolyl-L-alpha-glutamyl-L-tyrosine, dihydrogen phosphate (ester) |
| Anwendung: | InsRbeta submembrane domain NPEY phosphorylated peptide derivative |
| CAS | 290810-63-8 |
| MW: | 601.51 D |
ab 99,00 €
Anti-Insulin Receptor/INSR/CD220 Monoclonal Antibody
Artikelnummer: E-AN200037P.100
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which...
| Schlagworte: | INSR, EC=2.7.10.1, Insulin Receptor/INSR/CD220 Monoclonal Antibody |
| Anwendung: | IHC (paraffin) |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
Linsitinib
Artikelnummer: Cay17708-1
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
| Schlagworte: | OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol |
| Anwendung: | IGF-1R & InsR kinase inhibitor |
| CAS | 867160-71-2 |
| MW: | 421.5 D |
ab 60,00 €
INSRb Reporter Assay System (human)
Artikelnummer: IB-IB28001
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | INSR, EC=2.7.10.1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
1.588,00 €
bpV(phen)
Artikelnummer: AG-CR1-0042-M005
Potent protein phosphotyrosine phosphatase inhibitor Insulin receptor kinase (IRK) inducer, Insulin mimetic in vitro and in vivo, Apoptosis inducer, ERK inducer, Mitogen-activated protein kinase phosphatase-1 (MKP-1) inducer, Angiogenesis inhibitor.
| Schlagworte: | Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V) |
| Anwendung: | PTP inhibitor, IRK inducer |
| MW: | 350,2 D |
ab 55,00 €
Anti-Insulin Receptor Beta
Artikelnummer: A303-712A
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | Anti-INSR, EC=2.7.10.1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
BMS 754807
Artikelnummer: Cay17505-10
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
| Schlagworte: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
| Anwendung: | IGF-1R / InsR inhibitor |
| CAS | 1001350-96-4 |
| MW: | 461.5 D |
ab 67,00 €
GSK-1904529A
Artikelnummer: LKT-G7541.1
GSK-1904529A is an inhibitor of the insulin receptor (InsR) and IGF-1R that exhibits anticancer chemotherapeutic activity. In cellular and animal models of multiple myeloma and Ewing's sarcoma, GSK-1904529A induces cell cycle arrest and inhibits cell proliferation and tumor growth.
| Schlagworte: | GSK1904529A |
| Anwendung: | InsR / IGF-1R inhibitor |
| CAS | 1089283-49-7 |
| MW: | 851.96 D |
ab 164,00 €
GSK1904529A
Artikelnummer: Cay29155-1
GSK1904529A is a dual inhibitor of the insulin receptor (InsR) and insulin-like growth factor 1 receptor (IGF-1R) kinases (IC50s = 25 and 27 nM, respectively, in a cell-free assay). It selectively inhibits InsR and IGF-1R kinases over a panel of 45 serine/threonine and tyrosine kinases (IC50s = >1 µM for all)....
| Schlagworte: | N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-p... |
| Anwendung: | Insulin receptor / IGF-1R dual inhibitor |
| CAS | 1089283-49-7 |
| MW: | 852 D |
ab 49,00 €
HNMPA-(AM)3
Artikelnummer: Cay23245-1
HNMPA-(AM)3 is a cell-permeable prodrug form of the insulin receptor tyrosine kinase (IRTK) inhibitor HNMPA (Cay-15543). HNMPA-(AM)3 inhibits IRTK autophosphorylation in CHO cells expressing the human receptor in a concentration- and time-dependent manner. It inhibits 2-deoxyglucose uptake but does not affect...
| Schlagworte: | P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-phosphonic acid, bis[(acetyloxy)methyl] ester |
| Anwendung: | Cell-permeable insulin receptor inhibitor prodrug |
| CAS | 120944-03-8 |
| MW: | 454.4 D |
ab 73,00 €
Insulin (human)
Artikelnummer: TGM-T8221-25mg
Description: Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients. Target: IGF-1R. Smiles:...
| Schlagworte: | INSULIN, Insulin(human) |
| Anwendung: | Targets insulin receptor [EC:2.7.10.1] (INSR, CD220) |
| CAS | 11061-68-0 |
| MW: | 5807.57 D |
ab 30,00 €