Zu "K04527" wurden 113 Artikel gefunden!
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Human ISR (Insulin Receptor) ELISA Kit
Artikelnummer: ELK-ELK2639.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ISR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ISR. Next,...
| Schlagworte: | INSR, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Mouse ISR (Insulin Receptor) ELISA Kit
Artikelnummer: ELK-ELK4976.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ISR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ISR. Next,...
| Schlagworte: | Insr, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
INSRb Reporter Assay System (human)
Artikelnummer: IB-IB28001
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | INSR, EC=2.7.10.1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
1.448,00 €
INSRb Reporter Assay System (human)
Artikelnummer: IB-IB28002
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | INSR, EC=2.7.10.1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
3.802,00 €
Linsitinib
Artikelnummer: Cay17708-1
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
| Schlagworte: | OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol |
| Anwendung: | IGF-1R & InsR kinase inhibitor |
| CAS | 867160-71-2 |
| MW: | 421.5 D |
ab 54,00 €
bpV(phen)
Artikelnummer: AG-CR1-0042-M005
Potent protein phosphotyrosine phosphatase inhibitor Insulin receptor kinase (IRK) inducer, Insulin mimetic in vitro and in vivo, Apoptosis inducer, ERK inducer, Mitogen-activated protein kinase phosphatase-1 (MKP-1) inducer, Angiogenesis inhibitor.
| Schlagworte: | Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V) |
| Anwendung: | PTP inhibitor, IRK inducer |
| MW: | 350,2 D |
ab 66,00 €
Anti-Insulin Receptor Beta
Artikelnummer: A303-712A
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | Anti-INSR, EC=2.7.10.1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Anti-phospho-Insulin Receptor (Tyr1150/1151), clone 10C3
Artikelnummer: 0143-100
| Schlagworte: | (pY1150) EC=2.7.10.1, Anti-phospho-IR, Anti-phospho-INSR, Anti-phospho-CD220, Anti-phospho-Insulin receptor,... |
| Anwendung: | WB, ELISA |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
383,00 €
BMS 754807
Artikelnummer: Cay17505-10
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
| Schlagworte: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
| Anwendung: | IGF-1R / InsR inhibitor |
| CAS | 1001350-96-4 |
| MW: | 461.5 D |
ab 60,00 €
GSK-1904529A
Artikelnummer: LKT-G7541.1
GSK-1904529A is an inhibitor of the insulin receptor (InsR) and IGF-1R that exhibits anticancer chemotherapeutic activity. In cellular and animal models of multiple myeloma and Ewing's sarcoma, GSK-1904529A induces cell cycle arrest and inhibits cell proliferation and tumor growth.
| Schlagworte: | GSK1904529A |
| Anwendung: | InsR / IGF-1R inhibitor |
| CAS | 1089283-49-7 |
| MW: | 851.96 D |
ab 156,00 €
GSK1904529A
Artikelnummer: Cay29155-1
GSK1904529A is a dual inhibitor of the insulin receptor (InsR) and insulin-like growth factor 1 receptor (IGF-1R) kinases (IC50s = 25 and 27 nM, respectively, in a cell-free assay). It selectively inhibits InsR and IGF-1R kinases over a panel of 45 serine/threonine and tyrosine kinases (IC50s = >1 µM for all)....
| Schlagworte: | N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-p... |
| Anwendung: | Insulin receptor / IGF-1R dual inhibitor |
| CAS | 1089283-49-7 |
| MW: | 852 D |
ab 43,00 €
Anti-Insulin receptor
Artikelnummer: ARG55717.100
Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...
| Schlagworte: | Anti-INSR, EC=2.7.10.1 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
584,00 €