Zu "K04463" wurden 37 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Recombinant MEK5, clone A623
Artikelnummer: E-AN301907L.100
MEK5 is a dual specific kinase that specifically activates ERK5 involved in the regulation of diverse cellular processes, including cell growth, survival, and differentiation. The MEK5-ERK5 pathway is activated in numerous cancer types and plays a role in tumor growth and metastasis. Pharmacological targeting of the...
| Schlagworte: | Anti-MAP2K5, Anti-MAPK/ERK kinase 5, Anti-Dual specificity mitogen-activated protein kinase kinase 5, Recombinant MEK5... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
MEK Inhibitor
Artikelnummer: Cay43190-1
MEK inhibitor is an inhibitor of MEK5 (IC50 = 1. nM). It is selective for MEK5 over ERK5, activin receptor-like kinase 5 (ALK5), also known as TGF-beta receptor type I (TGF-betaRI), MEK1, and MEK2 (IC50s = 59, 580, >6,300, and >6,300 nM, respectively) and a panel of 79 other kinases at 10 µM. MEK inhibitor (1, 3, or...
| Schlagworte: | BIX02189, (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-6-carboxamide |
| Anwendung: | MEK5 (MAP2K5) inhibitor |
| CAS | 334951-92-7 |
| MW: | 426.52 D |
ab 147,00 €
BIX02189
Artikelnummer: Cay16999-5
BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C. It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2. BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting...
| Schlagworte: | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide |
| Anwendung: | MEK5 / ERK5 inhibitor |
| CAS | 1265916-41-3 |
| MW: | 440.5 D |
ab 174,00 €
BIX02188
Artikelnummer: Cay16238-1
BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFbetaR1 (IC50s = 810 and 1,800 nM, respectively). It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM). BIX02188 inhibits phosphorylation of ERK5 in a...
| Schlagworte: | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide |
| Anwendung: | MEK5 inhibitor |
| CAS | 334949-59-6 |
| MW: | 412.5 D |
ab 67,00 €
Anti-phospho-MEK5 (Ser311/ Thr315)
Artikelnummer: ARG51840.100
Protein function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. [The UniProt Consortium]
| Schlagworte: | Anti-phospho-Mek5, Anti-phospho-MEK 5, Anti-phospho-Map2k5, Anti-phospho-MAPKK 5, EC=2.7.12.2, Anti-phospho-MAPK/ERK... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 471,00 €
Human MEK5 ELISA Kit
Artikelnummer: G-HUFI00415.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-phospho-MEK5 (Ser311/Thr315)
Artikelnummer: 612-401-D74
Anti-MEK5 pS311/pT315 antibody is directed againstrat MEK5. MEK5 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide. Expect...
| Schlagworte: | Anti-phospho-Mek5, Anti-phospho-MEK 5, Anti-phospho-Map2k5, Anti-phospho-MAPKK 5, EC=2.7.12.2, Anti-phospho-MAPK/ERK... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat, human, mouse |
877,00 €
Anti-MAP2K5
Artikelnummer: E-AB-10512.120
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The...
| Schlagworte: | Anti-MEK5, Anti-MEK 5, Anti-MAP2K5, Anti-MAPKK 5, EC=2.7.12.2, Anti-MAPK/ERK kinase 5, Anti-MAP kinase kinase 5, Anti-Dual... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-MEK5
Artikelnummer: ARG40804.100
Protein function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. [The UniProt Consortium]
| Schlagworte: | Anti-MEK5, Anti-MEK 5, Anti-MAP2K5, Anti-MAPKK 5, EC=2.7.12.2, Anti-MAPK/ERK kinase 5, Anti-MAP kinase kinase 5, Anti-Dual... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
Anti-MAP2K5
Artikelnummer: ATA-HPA027347.100
Protein function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. [The UniProt Consortium] Buffer:...
| Schlagworte: | Anti-MEK5, Anti-MEK 5, Anti-MAP2K5, Anti-MAPKK 5, EC=2.7.12.2, Anti-MAPK/ERK kinase 5, Anti-MAP kinase kinase 5, Anti-Dual... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-MAP2K5
Artikelnummer: ATA-HPA027755.100
Protein function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. [The UniProt Consortium] Buffer:...
| Schlagworte: | Anti-MEK5, Anti-MEK 5, Anti-MAP2K5, Anti-MAPKK 5, EC=2.7.12.2, Anti-MAPK/ERK kinase 5, Anti-MAP kinase kinase 5, Anti-Dual... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-MEK5 / MAP2K5
Artikelnummer: NSJ-RQ6324
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically...
| Schlagworte: | Anti-MEK5, Anti-MEK 5, Anti-MAP2K5, Anti-MAPKK 5, EC=2.7.12.2, Anti-MAPK/ERK kinase 5, Anti-MAP kinase kinase 5, Anti-Dual... |
| Anwendung: | WB, IHC (paraffin), IF, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €