Zu "K04447" wurden 228 Artikel gefunden!
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NEU
Anti-JAK2 (9B4), monoclonal
Artikelnummer: ELK-EM1368.100
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Protein Function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates...
| Schlagworte: | Anti-JAK2, Anti-Janus kinase 2, Anti-Tyrosine-protein kinase JAK2, JAK2 (9B4) Mouse mAb |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 173,00 €
TG-89
Artikelnummer: TGM-T20742-100mg
Description: TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 µM against JAK2, showing anticancer activity in the treatment of ovarian and cervical cancer. Target: JAK, FLT, c-RET. Smiles: Cc1cnc(Nc2cccc(CN3CCOCC3)c2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C. References: FURUKAWA Y, et al....
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-56-4 |
| MW: | 510.65 D |
ab 35,00 €
Peficitinib
Artikelnummer: TGM-T6933-10mg
Description: Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3. Target: Tyrosine Kinases, JAK. Smiles: [H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)C2Nc1c(cnc2[nH]ccc12)C(N)=O. References: Párrizas M, et al. Endocrinology, 1997, 138(4), 1427-1433
| Schlagworte: | JNJ-54781532, ASP015K |
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 944118-01-8 |
| MW: | 326.39 D |
ab 33,00 €
JAK2 Inhibitor IV
Artikelnummer: Cay45230-1
A JAK2 inhibitor (IC50 = 78 nM). SMILES: NC1=NNC2=CC=C(C3=CC=C(S(NC(C)(C)C)(=O)=O)C=C3)C=C21. InChi Code: InChI=1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20). InChi Key: KFJCXIOVAGJCKB-UHFFFAOYSA-N
| Schlagworte: | Janus-Associated Kinase 2 Inhibitor IV, 4-(3-amino-1H-indazol-5-yl)-N-(1,1-dimethylethyl)-benzenesulfonamide |
| Anwendung: | JAK2 inhibitor |
| CAS | 1110502-30-1 |
| MW: | 344.43 D |
ab 74,00 €
Ruxolitinib
Artikelnummer: Cay11609-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | INCB 018424, betaR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| Anwendung: | Jak1/2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306.4 D |
ab 45,00 €
Ruxolitinib phosphate
Artikelnummer: TGM-T3043-5mg
Description: Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Target: Autophagy, Mitophagy, JAK. Smiles: OP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12....
| Schlagworte: | INCB018424, INC 424 phosphate, INC424, INCB018424 phosphate, Ruxolitinib (INCB-18424) phosphate |
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1092939-17-7 |
| MW: | 404.36 D |
ab 42,00 €
COVID-19 Forschung
Ruxolitinib
Artikelnummer: AG-CR1-3624-M025
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,4 D |
ab 72,00 €
Jak2 (V617F, W659A, W777A, F794H), His-Avi-Tag,...
Artikelnummer: BPS-79498
Human Jak2 with V617F, W659A, W777A, and F794H mutations, GenBank Accession No. NM_004972, a.a. 536-812, with C-terminal His-Avi-Tag, expressed in an Sf9 cell expression system and enzymatically Biotin-labeled using AviTag(TM) technology. MW=35 kDa.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | Kinase assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 35 kD |
573,00 €
JAK2-His-Avi-Tag, Biotin-Labeled
Artikelnummer: BPS-79074
Human Jak2 (GenBank Accession No. NM_004972), (a.a. 513-827) with C-terminal His-Avi-tag, MW=39 kDa, expressed in an Sf9 expression system. This protein was biotinylated using AviTag(TM) technology.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | WB positive control |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 39 kD |
566,00 €
JAK Inhibitor I
Artikelnummer: Cay15146-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
| Schlagworte: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
| Anwendung: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.3 D |
ab 45,00 €
Anti-JAK2
Artikelnummer: A302-178A
Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with...
| Schlagworte: | Anti-JAK2, Anti-JAK-2, Anti-Janus kinase 2, Anti-Tyrosine-protein kinase JAK2 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
AG-490
Artikelnummer: Cay10010311-5
Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of...
| Schlagworte: | Tyrphostin AG-490, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| Anwendung: | JAK2 inhibitor |
| CAS | 133550-30-8 |
| MW: | 294.3 D |
ab 51,00 €