Zu "K04447" wurden 227 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
NEU
JAK2 Inhibitor IV
Artikelnummer: Cay45230-1
A JAK2 inhibitor (IC50 = 78 nM). SMILES: NC1=NNC2=CC=C(C3=CC=C(S(NC(C)(C)C)(=O)=O)C=C3)C=C21. InChi Code: InChI=1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20). InChi Key: KFJCXIOVAGJCKB-UHFFFAOYSA-N
| Schlagworte: | Janus-Associated Kinase 2 Inhibitor IV, 4-(3-amino-1H-indazol-5-yl)-N-(1,1-dimethylethyl)-benzenesulfonamide |
| Anwendung: | JAK2 inhibitor |
| CAS | 1110502-30-1 |
| MW: | 344.43 D |
ab 72,00 €
JAK2-His-Avi-Tag, Biotin-Labeled
Artikelnummer: BPS-79074
Human Jak2 (GenBank Accession No. NM_004972), (a.a. 513-827) with C-terminal His-Avi-tag, MW=39 kDa, expressed in an Sf9 expression system. This protein was biotinylated using AviTag(TM) technology.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | WB positive control |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 39 kD |
566,00 €
Ruxolitinib
Artikelnummer: Cay11609-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | INCB 018424, betaR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| Anwendung: | Jak1/2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306.4 D |
ab 44,00 €
Ruxolitinib
Artikelnummer: AG-CR1-3624-M100
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,4 D |
ab 72,00 €
Jak2 (V617F, W659A, W777A, F794H), His-Avi-Tag,...
Artikelnummer: BPS-79498
Human Jak2 with V617F, W659A, W777A, and F794H mutations, GenBank Accession No. NM_004972, a.a. 536-812, with C-terminal His-Avi-Tag, expressed in an Sf9 cell expression system and enzymatically Biotin-labeled using AviTag(TM) technology. MW=35 kDa.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | Kinase assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 35 kD |
573,00 €
JAK Inhibitor I
Artikelnummer: Cay15146-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
| Schlagworte: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
| Anwendung: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.3 D |
ab 44,00 €
Anti-JAK2
Artikelnummer: A302-178A
Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with...
| Schlagworte: | Anti-JAK2, Anti-JAK-2, Anti-Janus kinase 2, Anti-Tyrosine-protein kinase JAK2 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
AG-490
Artikelnummer: Cay10010311-5
Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of...
| Schlagworte: | Tyrphostin AG-490, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| Anwendung: | JAK2 inhibitor |
| CAS | 133550-30-8 |
| MW: | 294.3 D |
ab 49,00 €
AZD 1480
Artikelnummer: Cay10702-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD...
| Schlagworte: | 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
| Anwendung: | JAK2 inhibitor |
| CAS | 935666-88-9 |
| MW: | 348.8 D |
ab 56,00 €
Ruxolitinib . phosphate salt
Artikelnummer: AG-CR1-3645-M100
White to off-white solid. Soluble in DMSO (>100mg/ml) and water (8mg/ml). Slightly soluble in 100% ethanol. Water-soluble phosphate salt of Ruxolitinib, Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1?/?JAK2 inhibitor |
| CAS | 1092939-17-7 |
| MW: | 404,4 D |
ab 44,00 €
Baricitinib
Artikelnummer: Cay16707-25
Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
| Schlagworte: | INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Anwendung: | JAK1 / JAK2 inhibitor |
| CAS | 1187594-09-7 |
| MW: | 371.4 D |
ab 79,00 €
Jak2 (JH1 domain), His-tag
Artikelnummer: BPS-40450
Human Jak2 (GenBank Accession No. NM_004972), (a.a. 808-end) with N-terminal His-tag, MW=42.5 kDa, expressed in a baculovirus expression system.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 42,5 kD |
611,00 €