Zu "K04447" wurden 176 Artikel gefunden!
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Human JAK2 (Tyrosine-Protein Kinase JAK2) ELISA Kit
Artikelnummer: ELK-ELK0731.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human JAK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human JAK2. Next,...
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Rat JAK2 (Janus Kinase 2) ELISA Kit
Artikelnummer: ELK-ELK6534.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat JAK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat JAK2. Next,...
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Anti-JAK2
Artikelnummer: ELK-EA341.50
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates...
| Schlagworte: | Anti-JAK-2, Anti-Janus kinase 2, Anti-Tyrosine-protein kinase JAK2, JAK2 Rabbit pAb |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
169,00 €
Ruxolitinib
Artikelnummer: Cay11609-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | INCB 018424, betaR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| Anwendung: | Jak1/2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306.4 D |
ab 32,00 €
JAK Inhibitor 31
Artikelnummer: Cay39387-1
JAK inhibitor 31 is an inhibitor of JAK2 (IC50 = 3.9 nM). It is selective for JAK2 over JAK3 (IC50s = 70 nM), as well as Aurora B kinase, VEGFR2, Abl1, and GSK3beta (IC50s = 0.441, 1.5, 21.37, and 50 µM, respectively), but does inhibit JAK1 and TYK2 (IC50s = 7 and 2.9 nM, respectively). JAK inhibitor 31 inhibits...
| Schlagworte: | Janus-Associated Kinase Inhibitor 31,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 2891469-99-9 |
| MW: | 398.5 D |
ab 68,00 €
COVID-19 Forschung
Ruxolitinib
Artikelnummer: AG-CR1-3624-M025
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,4 D |
ab 72,00 €
WP1130
Artikelnummer: AG-CR1-3551-M001
WP1130 is a second-generation tyrphostin derivative initially identified as a JAK2 signaling inhibitor through JAK2 ubiquitination that reduces STAT activation stimulated by cytokines (such as IL-6 and IL-3) through the rapid down-regulation of upstream JAK kinases. WP1130 has also been identified as a partially...
| Schlagworte: | WPI 130, Degrasyn, (2E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide |
| Anwendung: | Second-generation tyrphostin derivative, JAK2 signaling inhibitor, JAK2 ubiquitination inducer |
| CAS | 856243-80-6 |
| MW: | 384,3 D |
ab 33,00 €
Jak2 (V617F, W659A, W777A, F794H), His-Avi-Tag,...
Artikelnummer: BPS-79498
Human Jak2 with V617F, W659A, W777A, and F794H mutations, GenBank Accession No. NM_004972, a.a. 536-812, with C-terminal His-Avi-Tag, expressed in an Sf9 cell expression system and enzymatically Biotin-labeled using AviTag(TM) technology. MW=35 kDa.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | Kinase assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 35 kD |
562,00 €
JAK2-His-Avi-Tag, Biotin-Labeled
Artikelnummer: BPS-79074
Human Jak2 (GenBank Accession No. NM_004972), (a.a. 513-827) with C-terminal His-Avi-tag, MW=39 kDa, expressed in an Sf9 expression system. This protein was biotinylated using AviTag(TM) technology.
| Schlagworte: | JAK-2, Janus kinase 2, Tyrosine-protein kinase JAK2, |
| Anwendung: | WB positive control |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 39 kD |
555,00 €
JAK Inhibitor I
Artikelnummer: Cay15146-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
| Schlagworte: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
| Anwendung: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.3 D |
ab 39,00 €
Anti-JAK2
Artikelnummer: A302-178A
Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with...
| Schlagworte: | Anti-JAK2, Anti-JAK-2, Anti-Janus kinase 2, Anti-Tyrosine-protein kinase JAK2 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
AG-490
Artikelnummer: Cay10010311-5
Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of...
| Schlagworte: | Tyrphostin AG-490, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| Anwendung: | JAK2 inhibitor |
| CAS | 133550-30-8 |
| MW: | 294.3 D |
ab 43,00 €