Zu "K04407" wurden 37 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
DMX-5084
Artikelnummer: Cay42334-10
A MAP4K4 inhibitor (IC50 = 3 nM), selective for MAP4K4 over a panel of 141 kinases at 1 µM but does inhibit MAP4K6 and TNIK (IC50s = 6.61 and 10.96 nM, respectively), prevents hydrogen peroxide-induced decreases in viability in vCor.4U cells (EC50 = 3.16 nM), inhibits menadione-induced decreases in the OCR and ECAR...
| Schlagworte: | 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-4H-pyrrolo[2,3-d]pyrimidin-4-one |
| Anwendung: | MAP4K4 (HGK) inhibitor |
| CAS | 2306178-56-1 |
| MW: | 361.39 D |
ab 112,00 €
2-DI-1-ASP
Artikelnummer: Cay42328-1
A fluorescent mitochondrial probe, has been used to image actively respiring mitochondria in vitro, ex/em = 474/605 nm, respectively. Formulation: A solid. InChI: InChI=1S/C16H19N2.HI/c1-17(2)15-10-7-14(8-11-15)9-12-16-6-4-5-13-18(16)3,/h4-13H,1-3H3,1H/q+1,/p-1. InChIKey: XPOIQAIBZGSIDD-UHFFFAOYSA-M. SMILES:...
| Schlagworte: | DASPI, DASPMI, 2-[2-[4-(dimethylamino)phenyl]ethenyl]-1-methyl-pyridinium, monoiodide |
| Anwendung: | Fluorescent mitochondrial probe |
| CAS | 2156-29-8 |
| MW: | 366.2 D |
ab 53,00 €
Anti-MAP4K4/HGK
Artikelnummer: A301-503A
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
GNE-495
Artikelnummer: Cay21808-1
GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name:...
| Schlagworte: | 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.4 D |
ab 67,00 €
PF-6260933
Artikelnummer: Cay29220-50
PF-6260933 is an inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4, IC50 = 3.7 nM). It is selective for MAP4K4 over a panel of 41 kinases at 1 µM but also inhibits TRAF2- and NCK-interacting kinase (TNIK) and misshapen-like kinase 1 (MINK1, IC50s = 15 and 8 nM, respectively). PF-6260933...
| Schlagworte: | PF-06260933, 5-(4-chlorophenyl)-3,3'-bipyridine]-6,6'-diamine |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.8 D |
ab 168,00 €
GNE-495
Artikelnummer: TGM-TQ0079-1mg
Description: GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. Target: MAPK. Smiles: Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1. References: Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS...
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.42 D |
ab 34,00 €
Anti-MAP4K4/HGK
Artikelnummer: A301-502A
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-MAP4K4/HGK (IHC)
Artikelnummer: IHC-00536
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-NIK (Nck-interacting kinase)
Artikelnummer: NSJ-F50948-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain...
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
Anti-MAP4K4
Artikelnummer: ATA-HPA008476.100
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr- 322. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-MAP4K4
Artikelnummer: CSB-PA002905.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 126,00 €
PF-06260933
Artikelnummer: TGM-T4221-100mg
Description: PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively. Target: MAPK. Smiles: Nc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1. References: Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based...
| Schlagworte: | PF6260933, PF-6260933, PF 6260933 |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.75 D |
ab 40,00 €