Zu "K04407" wurden 30 Artikel gefunden!
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Anti-MAP4K4/HGK
Artikelnummer: A301-503A
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
GNE-495
Artikelnummer: Cay21808-1
GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name:...
| Schlagworte: | 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.4 D |
ab 60,00 €
Anti-MAP4K4/HGK
Artikelnummer: A301-502A
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-MAP4K4/HGK (IHC)
Artikelnummer: IHC-00536
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-NIK (Nck-interacting kinase)
Artikelnummer: NSJ-F50948-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain...
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Anti-MAP4K4
Artikelnummer: G-CAB11706.100
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 352,00 €
Anti-MAP4K4
Artikelnummer: ATA-HPA008476.100
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr- 322. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 300,00 €
PF-6260933
Artikelnummer: Cay29220-10
PF-6260933 is an inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4, IC50 = 3.7 nM). It is selective for MAP4K4 over a panel of 41 kinases at 1 µM but also inhibits TRAF2- and NCK-interacting kinase (TNIK) and misshapen-like kinase 1 (MINK1, IC50s = 15 and 8 nM, respectively). PF-6260933...
| Schlagworte: | PF-06260933, 5-(4-chlorophenyl)-3,3'-bipyridine]-6,6'-diamine |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.8 D |
ab 150,00 €
Anti-MAP4K4
Artikelnummer: E-AB-90296.120
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that...
| Schlagworte: | HGK, MAP4K4, MEKKK 4, EC=2.7.11.1, MEK kinase kinase 4, Nck-interacting kinase, HPK/GCK-like kinase HGK, MAPK/ERK kinase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 198,00 €
Anti-HGK
Artikelnummer: ELK-ES2511.100
mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the...
| Schlagworte: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Anwendung: | WB, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 169,00 €
HGK (MAP4K4 ), GST-tag
Artikelnummer: BPS-40109
Recombinant human HGK (a.a. 1-328), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
| Schlagworte: | HGK, MAP4K4, MEKKK 4, EC=2.7.11.1, MEK kinase kinase 4, Nck-interacting kinase, HPK/GCK-like kinase HGK, MAPK/ERK kinase... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 64 kD |
862,00 €
MAP4K4, Human mitogen-activated protein kinase kinase...
Artikelnummer: VHPS-5538
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | HGK, MAP4K4, MEKKK 4, EC=2.7.11.1, MEK kinase kinase 4, Nck-interacting kinase, HPK/GCK-like kinase HGK, MAPK/ERK kinase... |
| Anwendung: | RNA quantification |
43,00 €