Zu "K04382" wurden 83 Artikel gefunden!
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Protein Phosphatase 2A C subunit (human, recombinant,...
Artikelnummer: Cay10011237-10
Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also...
| Schlagworte: | RP-C, RP-C, PPP2CA, PP2A-alpha, PP2A-alpha, Replication protein C, Replication protein C, Serine/threonine-protein... |
| Anwendung: | Enzyme activity |
| MW: | 38,6 kD |
385,00 €
Anti-phospho-PP2A-Calpha (Tyr307)
Artikelnummer: ELK-ES6710.100
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory...
| Schlagworte: | Anti-phospho-RP-C, Anti-phospho-PPP2CA, Anti-phospho-PP2A-alpha, Anti-phospho-Replication protein C,... |
| Anwendung: | WB, IP, IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €
Okadaic Acid
Artikelnummer: Cay10011490-50
Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM). It is a very weak inhibitor of PP2B (IC50 > 2 µM) and does...
| Schlagworte: | 35-demethyl DTX1, Acanthifolicin, NSC 677083, OA,... |
| Anwendung: | PP1 PP2A PP3 inhibitor |
| CAS | 78111-17-8 |
| MW: | 805 D |
ab 77,00 €
Calyculin A
Artikelnummer: Cay19246-10
Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively). It is without significant effect against PP2B, PP2C, and PP4. Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit...
| Schlagworte: | (-)-Calyculin A,... |
| Anwendung: | Cell-permeable PP1 / PP2A inhibitor |
| CAS | 101932-71-2 |
| MW: | 1009.2 D |
ab 189,00 €
Okadaic acid, sodium salt
Artikelnummer: LKT-O4104.25
Sodium salt form of okadaic acid, with somewhat greater stability after it is put into organic solvents.
| Anwendung: | Phosphatase inhibitor |
| CAS | 209266-80-8 |
| MW: | 827 D |
ab 288,00 €
LB-100
Artikelnummer: Cay29105-5
LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity. It reduces PP2A activity and is cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 µM, respectively). LB-100 inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells....
| Schlagworte: | (1R,4S)-rel-3-[(4-methyl-1-piperazinyl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid |
| Anwendung: | Protein phosphatase 2A (PP2A) inhibitor |
| CAS | 1632032-53-1 |
| MW: | 268.3 D |
ab 163,00 €
Fostriecin (sodium salt)
Artikelnummer: Cay14749-100
Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 µM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases...
| Schlagworte: | Antibiotic CI-920, Phosphotrienin,... |
| Anwendung: | PP2A/PP4 inhibitor |
| CAS | 87860-39-7 |
| MW: | 452.4 D |
ab 488,00 €
Okadaic acid (high purity)
Artikelnummer: AG-CN2-0056-C025
Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by...
| Schlagworte: | Halochondrine A, CCRIS 3329, HSDB 7243, 9,10-Deepithio-9,10-didehydroacanthifolicin |
| Anwendung: | Ser/Thr phosphatase inhibitor |
| CAS | 78111-17-8 |
| MW: | 805 D |
99,00 €
Rubratoxin A
Artikelnummer: Cay19605-250
Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A, IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells...
| Schlagworte: | BRN 1633008, HSDB 3532,... |
| Anwendung: | PP2A inhibitor |
| CAS | 22467-31-8 |
| MW: | 520.5 D |
ab 401,00 €
Okadaic acid
Artikelnummer: LKT-O4101.1
Okadaic acid is a non-phorbol type tumor promoter. Potent inhibitor of protein phosphatases in numerous cell types.
| Schlagworte: | Halochondrine A |
| Anwendung: | Phosphatase inhibitor |
| CAS | 78111-17-8 |
| MW: | 805 D |
ab 454,00 €
Rubratoxin A
Artikelnummer: AG-CN2-0092-C250
Isolated from Penicillium sp. Soluble in methanol, ethanol, acetone or DMSO. Mycotoxin. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. Antitumor agent. Antimetastatic.
| Schlagworte: | BRN 1633008, HSDB 3532 |
| Anwendung: | PP2A inhibitor |
| CAS | 22467-31-8 |
| MW: | 520,2 D |
ab 363,00 €