Zu "K04366" wurden 194 Artikel gefunden!
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Sorafenib
Artikelnummer: Cay10009644-10
Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1,...
| Schlagworte: | BAY 43-9006, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Anwendung: | Kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.8 D |
ab 53,00 €
BI-882370
Artikelnummer: Cay24273-5
BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715,...
| Schlagworte: | N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-1-propan... |
| Anwendung: | RAF inhibitor |
| CAS | 1392429-79-6 |
| MW: | 569.7 D |
ab 49,00 €
BAY 43-9006
Artikelnummer: AG-CR1-0025-M005
Antitumor compound, Broad-spectrum kinase inhibitor, Raf kinase inhibitor, Apoptosis inducer, Cytostatic, Angiogenesis inhibitor, Review.
| Schlagworte: | Sorafenib, N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide |
| Anwendung: | Raf kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464,8 D |
ab 17,00 €
Anti-RAF1/c-RAF
Artikelnummer: A301-519A
Protein function: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic...
| Schlagworte: | Anti-RAF, Anti-RAF1, Anti-cRaf, Anti-Raf-1, EC=2.7.11.1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
ZM 336372
Artikelnummer: Cay10010367-1
The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a...
| Schlagworte: | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide |
| Anwendung: | Raf-1 inhibitor |
| CAS | 208260-29-1 |
| MW: | 389.4 D |
ab 65,00 €
GW 5074
Artikelnummer: Cay10010368-1
Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway. This pathway mediates basic cellular functions, including proliferation, differentiation, and survival. GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM). It blocks...
| Schlagworte: | 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one |
| Anwendung: | Raf-1 inhbitor |
| CAS | 220904-83-6 |
| MW: | 520.9 D |
ab 56,00 €
c-Raf Kinase Assay Kit
Artikelnummer: BPS-79570
c-Raf (Raf-1, proto-oncogen c-Raf) is a member of the Raf (rapidly accelerated fibrosarcoma) kinase family that plays an important role in regulating the MEK and ERK pathways. The c-Raf Kinase Assay Kit is designed for measuring c-Raf activity for screening and profiling applications. The c-Raf Kinase Assay Kit...
| Schlagworte: | RAF, RAF1, cRaf, Raf-1, EC=2.7.11.1, Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
945,00 €
cRAF (RAF1)
Artikelnummer: BPS-40008
Human RAF1, also known as c-RAF (GenBank Accession No. NM_002880), a.a. 306-648, containing the mutations Y340D and Y341D, with N-terminal GST-tag, MW=65 kDa, expressed in an Baculovirus infected Sf9 cell expression system.
| Schlagworte: | RAF, cRaf, Raf-1, Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 65 kD |
566,00 €
Dabrafenib
Artikelnummer: LKT-D0004.5
A potent ATP-competitive inhibitor of b-Raf, b-Raf(V600E) and c-Raf.
| Schlagworte: | N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide |
| Anwendung: | B-Raf / B-Raf (V600E) / c-Raf inhibitor |
| CAS | 1195765-45-7 |
| MW: | 519.56 D |
ab 126,00 €
RAF709
Artikelnummer: Cay23820-1
RAF709 is a potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively). It is selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases. However, DDR1, DDR2, FRK, and PDGFRbeta are also inhibited by >80% at a concentration of 1 µM. RAF709...
| Schlagworte: | N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-benzamide |
| Anwendung: | B-RAF / C-RAF inhibitor |
| CAS | 1628838-42-5 |
| MW: | 542.6 D |
ab 67,00 €
GW5074
Artikelnummer: LKT-G8850.1
A potent, selective and cell-permeable c-Raf1 kinase inhibitor.
| Schlagworte: | 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one,... |
| Anwendung: | c-Raf1 kinase inhibitor |
| CAS | 220904-83-6 |
| MW: | 520.94 D |
ab 121,00 €
Regorafenib
Artikelnummer: SYN-1169-M010
Soluble in DMSO or ethanol. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR beta, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | BAY-73-4506 |
| Anwendung: | VEGFR2 / RET / Raf-1 inhibitor |
| CAS | 755037-03-7 |
| MW: | 482,8 D |
ab 123,00 €