Zu "K04366" wurden 203 Artikel gefunden!
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MCP110
Artikelnummer: Cay37725-1
MCP110 is an inhibitor of the protein-protein interaction between Ras and Raf-1. It inhibits the interaction between H-Ras and Raf-1 in a yeast two-hybrid assay when used at a concentration of 30 µM. MCP110 (20 µM) inhibits Ras-induced activation of Raf-1 and MEK1 activity in HT-1080 fibrosarcoma cells. In vivo,...
| Schlagworte: | N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-N-[2-(2-pyridinyl)ethyl]-benzenepentanamide |
| Anwendung: | Ras-Raf-1 protein-protein interaction inhibitor |
| CAS | 521310-51-0 |
| MW: | 508.7 D |
ab 47,00 €
Anti-phospho-Raf1 (Ser296)
Artikelnummer: NSJ-F54083-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis,...
| Schlagworte: | Anti-phospho-RAF, Anti-phospho-cRaf, Anti-phospho-Raf-1, Anti-phospho-Proto-oncogene c-RAF, Anti-phospho-RAF... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Anti-Raf1 / c-Raf
Artikelnummer: NSJ-F54084-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis,...
| Schlagworte: | Anti-RAF, Anti-cRaf, Anti-Raf-1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene serine/threonine-protein kinase, Raf1... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Anti-Raf1 / c-Raf
Artikelnummer: NSJ-F54952-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. RAF1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, RAF1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn...
| Schlagworte: | Anti-RAF, Anti-cRaf, Anti-Raf-1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene serine/threonine-protein kinase, Raf1... |
| Anwendung: | FC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Anti-RAF1/c-Raf Recombinant Monoclonal
Artikelnummer: A700-289
Protein function: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic...
| Schlagworte: | Anti-RAF, Anti-RAF1, Anti-cRaf, Anti-Raf-1, EC=2.7.11.1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene... |
| Anwendung: | WB, IP, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 172,00 €
Human CRAF (C-Raf Proto Oncogene Serine/Threonine Protein...
Artikelnummer: ELK-ELK3763.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CRAF. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CRAF. Next,...
| Schlagworte: | RAF, cRaf, Raf-1, Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Anti-c-Raf
Artikelnummer: ELK-EA215.100
A-Raf, B-Raf, and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases. Protein function: Serine/threonine-protein kinase...
| Schlagworte: | Anti-RAF, Anti-cRaf, Anti-Raf-1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene serine/threonine-protein kinase, c-Raf... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
Sorafenib
Artikelnummer: Cay10009644-10
Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1,...
| Schlagworte: | BAY 43-9006, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Anwendung: | Kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.8 D |
ab 43,00 €
BI-882370
Artikelnummer: Cay24273-5
BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715,...
| Schlagworte: | N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-1-propan... |
| Anwendung: | RAF inhibitor |
| CAS | 1392429-79-6 |
| MW: | 569.7 D |
ab 43,00 €
BAY 43-9006
Artikelnummer: AG-CR1-0025-M005
Antitumor compound, Broad-spectrum kinase inhibitor, Raf kinase inhibitor, Apoptosis inducer, Cytostatic, Angiogenesis inhibitor, Review.
| Schlagworte: | Sorafenib, N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide |
| Anwendung: | Raf kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464,8 D |
ab 17,00 €
Anti-RAF1/c-RAF
Artikelnummer: A301-519A
Protein function: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic...
| Schlagworte: | Anti-RAF, Anti-RAF1, Anti-cRaf, Anti-Raf-1, EC=2.7.11.1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
ZM 336372
Artikelnummer: Cay10010367-1
The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a...
| Schlagworte: | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide |
| Anwendung: | Raf-1 inhibitor |
| CAS | 208260-29-1 |
| MW: | 389.4 D |
ab 58,00 €