Zu "K04366" wurden 194 Artikel gefunden!

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Anti-phospho-RAF1(Ser621)
Anti-phospho-RAF1(Ser621)

Artikelnummer: E-AB-68081.120

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity...
Schlagworte: Anti-phospho-RAF, Anti-phospho-RAF1, Anti-phospho-cRaf, Anti-phospho-Raf-1, EC=2.7.11.1, Anti-phospho-Proto-oncogene...
Anwendung: IF
Reaktivität: Human
ab 181,00 €
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Anti-phospho-RAF1(Ser259)
Anti-phospho-RAF1(Ser259)

Artikelnummer: E-AB-68165.120

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity...
Schlagworte: Anti-phospho-RAF, Anti-phospho-RAF1, Anti-phospho-cRaf, Anti-phospho-Raf-1, EC=2.7.11.1, Anti-phospho-Proto-oncogene...
Anwendung: WB
Reaktivität: Human, Mouse
ab 181,00 €
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Belvarafenib
Belvarafenib

Artikelnummer: Cay31460-1

Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively). It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62...
Schlagworte: GDC-5573, HM95573,...
Anwendung: B-RAF / C-RAF inhibitor
CAS 1446113-23-0
MW: 478.9 D
ab 44,00 €
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BAY 43-9006
BAY 43-9006

Artikelnummer: Cay10009644-10

Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1,...
Schlagworte: BAY 43-9006, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Anwendung: Kinase inhibitor
CAS 284461-73-0
MW: 464.8 D
ab 32,00 €
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BI-882370
BI-882370

Artikelnummer: Cay24273-5

BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715,...
Schlagworte: N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-1-propan...
Anwendung: RAF inhibitor
CAS 1392429-79-6
MW: 569.7 D
ab 32,00 €
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Ro 5126766
Ro 5126766

Artikelnummer: Cay29197-5

Ro 5126766 is a dual inhibitor of MEK1 (IC50 = 160 nM) and Raf kinases (IC50s = 56, 19, and 8.2 nM for C-RAF, B-RAF, and B-RAFV600E, respectively). It is selective for these kinases over a panel of 254 additional kinases at 10 µM. Ro 5126766 (1 µM) decreases MEK and ERK phosphorylation in a panel of seven cancer...
Schlagworte: CH5126766, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl-sulfamide
Anwendung: MEK1 / RAF kinases dual inhibitor
CAS 946128-88-7
MW: 471.5 D
ab 75,00 €
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BAY 43-9006
BAY 43-9006

Artikelnummer: AG-CR1-0025-M005

Antitumor compound, Broad-spectrum kinase inhibitor, Raf kinase inhibitor, Apoptosis inducer, Cytostatic, Angiogenesis inhibitor, Review.
Schlagworte: Sorafenib, N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
Anwendung: Raf kinase inhibitor
CAS 284461-73-0
MW: 464,8 D
ab 17,00 €
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Anti-RAF1/c-RAF
Anti-RAF1/c-RAF

Artikelnummer: A301-519A

Protein function: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic...
Schlagworte: Anti-RAF, Anti-RAF1, Anti-cRaf, Anti-Raf-1, EC=2.7.11.1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene...
Anwendung: WB, IP
Reaktivität: Human, Mouse
ab 131,00 €
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ZM 336372
ZM 336372

Artikelnummer: Cay10010367-1

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a...
Schlagworte: 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide
Anwendung: Raf-1 inhibitor
CAS 208260-29-1
MW: 389.4 D
ab 43,00 €
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GW 5074
GW 5074

Artikelnummer: Cay10010368-1

Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway. This pathway mediates basic cellular functions, including proliferation, differentiation, and survival. GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM). It blocks...
Schlagworte: 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one
Anwendung: Raf-1 inhbitor
CAS 220904-83-6
MW: 520.9 D
ab 37,00 €
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Sorafenib, Free Base (Sorafenib, Bay 43-9006, Nexavar, CAS 284461-73-0), >99%
Sorafenib, Free Base (Sorafenib, Bay 43-9006, Nexavar,...

Artikelnummer: LC-S-8599_1g

Soluble in DMSO at 200 mg/mL, soluble in ethanol at 3.3 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
Schlagworte: Sorafenib, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Anwendung: Kinase inhibitor
CAS 284461-73-0
MW: 464,82 D
ab 69,00 €
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Dabrafenib
Dabrafenib

Artikelnummer: LKT-D0004.5

A potent ATP-competitive inhibitor of b-Raf, b-Raf(V600E) and c-Raf.
Schlagworte: N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Anwendung: B-Raf / B-Raf (V600E) / c-Raf inhibitor
CAS 1195765-45-7
MW: 519.56 D
ab 91,00 €
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