Zu "K04366" wurden 192 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
LXH254
Artikelnummer: LKT-L930280.1
LXH254 is a type II RAF inhibitor. SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=NC=C2)C(F)(F)F)C3=CC(=NC(=C3)OCCO)N4CCOCC4
| Schlagworte: | Naporafenib,... |
| Anwendung: | pan-RAF inhibitor |
| CAS | 1800398-38-2 |
| MW: | 502.49 D |
ab 84,00 €
Sorafenib
Artikelnummer: Cay10009644-10
Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1,...
| Schlagworte: | BAY 43-9006, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Anwendung: | Kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.8 D |
ab 44,00 €
Ro 5126766
Artikelnummer: TGM-T6971-100mg
Description: RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. Target: Raf, MEK. Smiles: CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F. References: Ishii N, et al. Cancer Res. 2013, 73(13), 4050-4060.
| Schlagworte: | CH5126766, Avutometinib, RO5126766, VS-6766 |
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 946128-88-7 |
| MW: | 471.46 D |
ab 52,00 €
Avutometinib potassium
Artikelnummer: TGM-T68270-100mg
Description: Avutometinib potassium is a MEK inhibitor (MEKi) that enhanced the inhibition of pseudovirus infection by GLPG-0187. It Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity. Target: Others. Smiles:...
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 946128-90-1 |
| MW: | 509.55 D |
ab 1.671,00 €
CCT241161
Artikelnummer: TGM-T9638-100mg
Description: CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It exhibits significant activity against BRAF and NRAS mutant melanomas and demonstrates anticancer cell proliferative effects [1]. Target: Raf. Smiles:...
| Anwendung: | Multi-kinase inhibitor |
| CAS | 1163719-91-2 |
| MW: | 541.62 D |
ab 139,00 €
RAF1 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-01995-100ug
Description: RAF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 89.1 kDa and the accession number is P04049.
| Schlagworte: | RAF1, Raf-1, Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase |
| MW: | 89.1 kD |
ab 198,00 €
RAF1 Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-05095-50ug
Description: RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual...
| Schlagworte: | NS5, CRAF, CMD1NN, Raf-1 proto-oncogene, serine/threonine kinase, Raf-1, c-Raf |
| MW: | 66.9 kD |
497,00 €
BI-882370
Artikelnummer: TGM-TQ0048-10mg
Description: BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases (IC50s: 0.4, 0.8 and 0.6 nM). BI-882370 also inhibits SRC family kinases. Target: Raf. Smiles: CCCS(=O)(=O)Nc1ccc(F)c(c1F)-n1cc(-c2cncnc2)c2nc(ccc12)N(C)C1CCN(CC)CC1. References:...
| Anwendung: | RAF inhibitor |
| CAS | 1392429-79-6 |
| MW: | 569.67 D |
ab 37,00 €
B-Raf IN 1
Artikelnummer: TGM-T1845-100mg
Description: B-Raf IN 1 is an inhibitor of B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM). Target: Raf. Smiles: CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1. References: Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1,19(23):6519-23.
| Anwendung: | BRAF / RAF1 inhibitor |
| CAS | 950736-05-7 |
| MW: | 515.53 D |
ab 83,00 €
ZM 336372
Artikelnummer: TGM-T1851-100mg
Description: ZM 336372 is a potent and selective c-Raf inhibitor. Target: Raf, Apoptosis. Smiles: CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1. References: Hall-Jackson CA, et al. Chem Biol, 1999, 6(8), 559-568.
| Schlagworte: | Zinc00581684 |
| Anwendung: | Raf-1 inhibitor |
| CAS | 208260-29-1 |
| MW: | 389.45 D |
ab 34,00 €
GW 5074
Artikelnummer: TGM-T6525-100mg
Description: GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms. Target: Apoptosis, Raf. Smiles: C(=C1C=2C(NC1=O)=CC=C(I)C2)C3=CC(Br)=C(O)C(Br)=C3. References: Chin PC, et...
| Schlagworte: | Raf1 Kinase Inhibitor I, GW5074 |
| Anwendung: | Raf-1 inhbitor |
| CAS | 220904-83-6 |
| MW: | 520.94 D |
ab 37,00 €
Pan-RAF kinase inhibitor 1
Artikelnummer: TGM-T63386-100mg
Description: Pan-RAF kinase inhibitor 1 is a potent inhibitor of the Pan-RAF kinase pair, which regulates MAPK signaling and affects the proliferation of RAS-mutated tumor cells. Pan-RAF kinase inhibitor 1 has shown research potential for the study of cancer diseases. Target: Others. Smiles:...
| Anwendung: | Pan-RAF kinase inhibitor |
| CAS | 2648838-76-8 |
| MW: | 499.48 D |
ab 2.142,00 €