Zu "K04363" wurden 265 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
NEU
N,N-dimethyl Sunitinib
Artikelnummer: Cay45148-1
A multi-kinase inhibitor and derivative of sunitinib, inhibits VEGFR1, VEGFR2, PDGFR, and c-Kit (IC50s = 0.013, 0.017, 0.005, and 0.04 µM, respectively), reduces the degradation of cartilage proteoglycan and the severity of arthritis in the K/BxN mouse model of rheumatoid arthritis at 40 mg/kg, reduces intratumoral...
| Schlagworte: | SU 11657,... |
| Anwendung: | Sunitinib derivative, multi-kinase inhibitor |
| CAS | 326914-17-4 |
| MW: | 370.43 D |
ab 425,00 €
Anti-Recombinant PDGFR-alpha, clone 4B4
Artikelnummer: E-AN300805L.100
PDGFRA(platelet derived growth factor receptor alpha) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer...
| Schlagworte: | Anti-PDGFRA, Anti-CD140a antigen, Anti-CD140 antigen-like family member A, Anti-Platelet-derived growth factor receptor 2,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-PGFRA
Artikelnummer: E-AN006950L.100
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Schlagworte: | Anti-PDGFRA, Anti-CD140a antigen, Anti-CD140 antigen-like family member A, Anti-Platelet-derived growth factor receptor 2,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 110,00 €
![PDGF R alpha/PDGFRA[Biotin], His & Avi, Human](https://www.biomol.com/media/image/31/24/39/GSC-Z04583-100_200x200.png "PDGF R alpha/PDGFRA[Biotin], His & Avi, Human")
PDGF R alpha/PDGFRA[Biotin], His & Avi, Human
Artikelnummer: GSC-Z04583-100
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two...
| Schlagworte: | PDGFRA, CD140a antigen, CD140 antigen-like family member A, Platelet-derived growth factor receptor 2, Platelet-derived... |
| Ursprungsart: | human |
| MW: | 59.2 kD |
ab 887,00 €
PDGF R alpha/PDGFRA, His & Avi, Human
Artikelnummer: GSC-Z05737-100
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two...
| Schlagworte: | PDGFRA, CD140a antigen, CD140 antigen-like family member A, Platelet-derived growth factor receptor 2, Platelet-derived... |
| Ursprungsart: | human |
| MW: | 59.2 kD |
ab 309,00 €
PDGF R alpha/PDGFRA, His, Mouse
Artikelnummer: GSC-Z06300-100
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two...
| Schlagworte: | Pdgfra, CD140 antigen-like family member A, Platelet-derived growth factor receptor alpha, Alpha platelet-derived growth... |
| Ursprungsart: | mouse |
| MW: | 57.08 kD |
ab 457,00 €
Anti-PDGFRA/CD140a Monoclonal Antibody
Artikelnummer: E-AN200022P.100
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Schlagworte: | PDGFR2, CD140a, PDGFRA, PDGFR-2, EC=2.7.10.1, PDGFR-alpha, PDGF-R-alpha, CD140a antigen, CD140 antigen-like family member... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
Lenvatinib
Artikelnummer: Cay19375-5
Lenvatinib is an inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and VEGFR3 (IC50s = 4 and 5.2 nM, respectively). It also inhibits the related kinases VEGFR1, FGFR1, PDGFRalpha, PDGFRbeta and Kit (IC50s = 22, 46, 51, 39, and 100 nM, respectively). Lenvatinib (30 mg/kg, twice per day) reduces...
| Schlagworte: | E-7080, ER-203492-00, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide |
| Anwendung: | VEGFR / FGFR / PDGFR inhibitor |
| CAS | 417716-92-8 |
| MW: | 426.9 D |
ab 49,00 €
AG-1296
Artikelnummer: Cay10010592-1
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the...
| Schlagworte: | Tyrphostin AG-1296, 6,7-dimethoxy-2-phenyl-quinoxaline |
| Anwendung: | PDGF receptor kinase inhibitor |
| CAS | 146535-11-7 |
| MW: | 266.3 D |
ab 42,00 €
SU 4312
Artikelnummer: Cay20213-1
SU 4312 is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 µM, respectively). It demonstrates IC50 values >100 µM at EGFR, HER2, and IGF-1R. SU 4312 has been shown to inhibit VEGF-dependent angiogenesis in a zebrafish assay (IC50 = 1.8 µM) without affecting normal...
| Schlagworte: | NSC 86429, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one |
| Anwendung: | Selective, cell-permeable VEGFR2 / PDGFR inhibitor |
| CAS | 5812-07-7 |
| MW: | 264.3 D |
ab 49,00 €
Anti-PDGFRA (CD140a)
Artikelnummer: NSJ-F50654-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. PDGFRA is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell...
| Schlagworte: | Anti-PDGFR2, Anti-PDGFRA, Anti-CD140a, Anti-PDGFR-2, Anti-PDGFR-alpha, EC=2.7.10.1, Anti-PDGF-R-alpha, Anti-CD140a... |
| Anwendung: | WB, IHC, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 361,00 €
Radotinib
Artikelnummer: Cay19923-1
Radotinib is a selective second generation tyrosine kinase inhibitor that targets both the wild-type and mutant forms of Bcr-Abl, with an IC50 value of 30.6 nM in Ba/F3 human chronic myeloid leukemia cells expressing the wild-type form. Radotinib also inhibits platelet-derived growth factor receptors (PDGFRs) alpha...
| Schlagworte: | IY-5511,... |
| Anwendung: | Bcr-Abl tyrosine kinase & PDGFR inhibitor |
| CAS | 926037-48-1 |
| MW: | 530.5 D |
ab 49,00 €