Zu "K04351" wurden 23 Artikel gefunden!
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ESI-08
Artikelnummer: Cay43208-10
ESI-08 is an inhibitor of exchange protein activated by cAMP 2 (Epac2, IC50 = 8. µM).. Solulibility: Acetonitrile: Slightly Soluble: 0.1-1 mg/mL: Water: Slightly Soluble: 0.1-1 mg/mL.
| Schlagworte: | 4-cyclohexyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinecarbonitrile |
| Anwendung: | Epac2 (RAPGEF4, Rap guanine nucleotide exchange factor 4) inhibitor |
| CAS | 301177-43-5 |
| MW: | 353.48 D |
ab 190,00 €
Anti-Rapgef4
Artikelnummer: ABS-KC-2510.100
Protein function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. [The UniProt Consortium]
| Schlagworte: | Anti-Rap guanine nucleotide exchange factor 4, Anti-Exchange factor directly activated by cAMP 2, Anti-Exchange protein... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | mouse |
ab 206,00 €
HJC0350
Artikelnummer: TGM-T6536-100mg
Description: HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 µM), and no inhibition of Epac1. Target: cAMP. Smiles: Cc1cc(C)n(c1)S(=O)(=O)c1c(C)cc(C)cc1C. References: Chen H, et al. J Med Chem. 2013, 56(3), 952-962.
| Anwendung: | RAPGEF4 inhibitor |
| CAS | 885434-70-8 |
| MW: | 277.38 D |
ab 31,00 €
ESI-05
Artikelnummer: TGM-T15247-100mg
Description: ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 µM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. Target: cAMP. Smiles: Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C. References: Tsalkova T, et al....
| Schlagworte: | NSC 116966 |
| Anwendung: | Rap guanine nucleotide exchange factor 4 (Epac2) inhibitor |
| CAS | 5184-64-5 |
| MW: | 274.38 D |
ab 34,00 €
ESI-09
Artikelnummer: Cay19130-1
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). ESI-09 is an inhibitor of Epac1 and Epac2 with IC50 values of 3.2 and 1.4 µM, respectively. It shows no activity against PKA at concentrations as high as 25 µM. ESI-09 has been shown to block Akt...
| Schlagworte: | alpha-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile |
| Anwendung: | Epac1 / Epac2 inhibitor |
| CAS | 263707-16-0 |
| MW: | 330.8 D |
ab 44,00 €
8-pCPT-2'-O-methyl Cyclic AMP
Artikelnummer: Cay17143-5
Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2'-O-methyl Cyclic AMP (8-pCPT-2'-O-Me-cAMP) is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM). It is a super-activator of Epacs in that it dissociates...
| Schlagworte: | 8-CPT-2Me-cAMP, 8-pCPT-cAMP, 8-pCPT-2'-O-Me-cAMP, 8-[(4-chlorophenyl)thio]-2'-O-methyl-adenosine cyclic 3',5'-(hydrogen... |
| Anwendung: | EPAC activator |
| CAS | 634207-53-7 |
| MW: | 507.8 D |
ab 155,00 €
HJC0350
Artikelnummer: Cay22949-1
HJC0350 is a selective inhibitor of exchange protein directly activated by cAMP 2 (Epac2) with an IC50 value of 300 nM for competition with 8-NBD-cAMP binding. It inhibits Epac2 guanine nucleotide exchange activity but does not inhibit Epac1-mediated Rap1-GDP exchange or cAMP-mediated protein kinase A (PKA)...
| Schlagworte: | 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole |
| Anwendung: | RAPGEF4 inhibitor |
| CAS | 885434-70-8 |
| MW: | 277.4 D |
ab 44,00 €
HJC0197
Artikelnummer: Cay19092-10
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 µM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 µM, but has no effect on cAMP-induced type I and II PKA...
| Schlagworte: | 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinecarbonitrile |
| Anwendung: | Cell-permeable Epac1 / Epac2 inhibitor |
| CAS | 1383539-73-8 |
| MW: | 339.5 D |
ab 52,00 €
ESI-05
Artikelnummer: Cay29702-1
ESI-05 is an inhibitor of exchange protein activated by cAMP 2 (Epac2) that inhibits cAMP-induced Epac2 guanine nucleotide exchange factor (GEF) activity with an IC50 value of 0.43 µM in a cell-free assay. It is selective for Epac2 over Epac1 and PKA at 25 µM. ESI-05 (1, 5, 10, and 25 µM) reduces activation of the...
| Schlagworte: | NSC 116966, 1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-benzene |
| Anwendung: | Rap guanine nucleotide exchange factor 4 (Epac2) inhibitor |
| CAS | 5184-64-5 |
| MW: | 274.4 D |
ab 44,00 €
Anti-RAPGEF4
Artikelnummer: ATA-HPA028968.100
Protein function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2)....
| Schlagworte: | Anti-CGEF2, Anti-EPAC 2, Anti-RAPGEF4, Anti-cAMP-GEFII, Anti-Rap guanine nucleotide exchange factor 4, Anti-Exchange... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 239,00 €
Anti-epac-1
Artikelnummer: CSB-PA019329XA01CXY.2
Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1:...
| Schlagworte: | Anti-epac-1, Anti-T20G5.5, Anti-Rap guanine nucleotide exchange factor 1, Anti-Exchange protein activated by cyclic AMP 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | Caenorhabditis elegans |
ab 1.529,00 €
RAPGEF4 (human), recombinant protein
Artikelnummer: ABS-PP-8085.20
| Schlagworte: | Rap guanine nucleotide exchange factor 4, Exchange factor directly activated by cAMP 2, Exchange protein directly... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 23.5 kD |
ab 90,00 €