Zu "K04325" wurden 46 Artikel gefunden!
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TUG-469
Artikelnummer: Cay44272-10
TUG-469 is an agonist of free fatty aid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in a reporter assay using cells expressing human FFAR1/GPR40 (EC50 = 18. nM). TUG-469 (10 µM) induces insulin secretion in INS-1E insulinoma cells. It inhibits increases in blood glucose levels in a glucose tolerance...
| Schlagworte: | 4-[[(2'-methyl[1,1'-biphenyl]-3-yl)methyl]amino]-benzenepropanoic acid |
| Anwendung: | FFAR1/GPR40 agonist |
| CAS | 1236109-67-3 |
| MW: | 345.44 D |
ab 38,00 €
CHO-K1/FFA1/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00273
Recombinant CHO-K1 cells stably overexpress human free fatty acid receptor 1 (FFA1) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.
| Schlagworte: | FFAR1, Free fatty acid receptor 1, G-protein coupled receptor 40 |
11.424,00 €
AM4668
Artikelnummer: Cay43419-1
An FFAR1/GPR40 agonist, induces IP3 production in A9 cells expressing human FFAR1/GPR40 (EC50 = 3.6 nM), induces insulin secretion from pancreatic islets isolated from FFAR1 knock-in mice, reduces blood glucose levels in FFAR1 knock-in mice at 10 mg/kg
| Schlagworte: | betaS-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl]-3-isoxazolepropanoic acid |
| Anwendung: | FFAR1/GPR40 agonist |
| CAS | 1011531-27-3 |
| MW: | 488.48 D |
ab 146,00 €
GW 1100
Artikelnummer: Cay10008908-5
GPR40 (free fatty acid receptor 1, FFAR1) is a G protein-coupled receptor (GPCR) that is activated by saturated and unsaturated long chain fatty acids. It is thought to play a role in the potentiation of insulin secretion by fatty acids in a glucose-sensitive manner. GW 1100 is a selective antagonist of...
| Schlagworte: | 4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-benzoic acid, ethyl ester |
| Anwendung: | GPR40 antagonist |
| CAS | 306974-70-9 |
| MW: | 520.6 D |
ab 110,00 €
LY2922470
Artikelnummer: Cay43109-1
LY2922470 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40). It induces calcium flux in HEK293 cells expressing FFAR1/GPR40 (EC50s = 7, 1, and 3 nM for the human, mouse, and rat receptor, respectively). LY2922470 (30 mg/kg) increases blood levels of glucagon-like peptide 1 (GLP-1) in fasted mice. It also...
| Schlagworte: | (betaS)-4-[[5-[(3,4-dihydro-8-methoxy-1(2H)-quinolinyl)methyl]-2-thienyl]methoxy]-beta-1-propyn-1-yl-benzenepropanoic acid |
| Anwendung: | FFAR1/GPR40 agonist |
| CAS | 1423018-12-5 |
| MW: | 475.6 D |
ab 116,00 €
PBI-4050 (sodium salt)
Artikelnummer: Cay42912-10
PBI-4050 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40) and an antagonist of G protein-coupled receptor 84 (GPR84). It induces beta-arrestin-2 recruitment in a reporter assay using HEK293 cells expressing human FFAR1/GPR40 (EC50 = 275 µM). PBI-4050 inhibits activation of GPR84 induced by decanoic acid...
| Schlagworte: | 2-(3-pentylphenyl)acetate, monosodium salt |
| Anwendung: | Anti-fibrotic agent, GPR40 agonist, GPR84 inverse agonist |
| MW: | 229.27 D |
ab 147,00 €
FFAR1 (GPR40) Reporter Assay Kit
Artikelnummer: Cay601190-1
Free fatty acid receptor 1 (FFAR1)/GPR40 is a G protein-coupled receptor for long-chain fatty acids such as docosahexaenoic acid and eicosapentaenoic acid omega-3 fatty acids. It is involved in the regulation of insulin release from pancreatic beta cells and mediates triglyceride-induced secretion of incretins GLP-1...
| Schlagworte: | Free Fatty Acid Receptor 1, G Protein-Coupled Receptor 40 |
| Anwendung: | Cell based assays, HTS, reverse transfection reporter assay |
| Spezies-Reaktivität: | human |
689,00 €
AMG 837
Artikelnummer: Cay21815-5
AMG 837 is a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in CHO cells expressing FFAR1/GPR40 but not FFAR2/GPR43, FFAR3/GPR41, or FFAR4/GPR120 (EC50s = 0.0135, >10, >10, and >10 µM, respectively). AMG 837 induces insulin secretion in MIN6 pancreatic beta-cells and...
| Schlagworte: | betaS-1-propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-benzenepropanoic acid |
| Anwendung: | Partial GPR40 agonist |
| CAS | 865231-46-5 |
| MW: | 438.4 D |
ab 56,00 €
TAK-875
Artikelnummer: Cay17335-1
The free fatty acid receptor 1 (FFAR1, GPR40) is highly expressed in pancreatic beta-cells and activated by medium and long-chain fatty acids. There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential...
| Schlagworte: | (3S)-6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid |
| Anwendung: | FFAR1/GPR40 agonist |
| CAS | 1000413-72-8 |
| MW: | 524.6 D |
ab 67,00 €
Anti-GPR40, C-terminal
Artikelnummer: ARG63777.100
Protein function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a...
| Schlagworte: | Anti-GPR40, Anti-FFAR1, Anti-Free fatty acid receptor 1, Anti-G-protein coupled receptor 40 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
TUG-770
Artikelnummer: Cay22131-1
TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells). It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a...
| Schlagworte: | 4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluoro-benzenepropanoic acid |
| Anwendung: | GPR40 agonist |
| CAS | 1402601-82-4 |
| MW: | 307.3 D |
ab 56,00 €
Human FFAR1 (Free Fatty Acid Receptor 1) ELISA Kit
Artikelnummer: ELK-ELK4221.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FFAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FFAR1. Next,...
| Schlagworte: | FFAR1, GPR40, Free fatty acid receptor 1, G-protein coupled receptor 40 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €