Zu "K04289" wurden 45 Artikel gefunden!
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Ki16425
Artikelnummer: Cay10012659-10
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively, as...
| Schlagworte: | 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid |
| Anwendung: | LPA receptor antagonist |
| CAS | 355025-24-0 |
| MW: | 475 D |
ab 56,00 €
BMS 986278
Artikelnummer: Cay43597-10
BMS 986278 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, Kb = 0. µM). It is selective for LPA1 over a panel of 44 receptors, ion channels, and enzymes when used at concentrations ranging from 30 to 150 µM, including the bile salt export pump (BSEP), multidrug resistance protein 3 (MDR3), multidrug...
| Schlagworte: | Admilparant,... |
| Anwendung: | LPA1 antagonist |
| CAS | 2170126-74-4 |
| MW: | 445.52 D |
ab 260,00 €
Anti-LPA1
Artikelnummer: Cay10005280-1
LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4). LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5). LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including...
| Schlagworte: | Anti-EDG2, Anti-LPAR1, Anti-LPA-1, Anti-LPA-1, Anti-LPA receptor 1, Anti-LPA receptor 1, Anti-Lysophosphatidic acid... |
| Anwendung: | ICC, IF, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
468,00 €
1-Stearoyl-2-Docosahexaenoyl-sn-glycero-3-PC
Artikelnummer: Cay25595-5
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid containing stearic acid (Cay-10011298) and docosahexaenoic acid (DHA, Cay-90310) at the sn-1 and sn-2 positions, respectively. It has been used in the study of lipid membrane organization and dynamics. The levels of...
| Schlagworte: | 18:0/22:6 PC, 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-Phosphatidylcholine,... |
| Anwendung: | Lysophospholipid |
| CAS | 59403-52-0 |
| MW: | 834.2 D |
ab 110,00 €
AM966
Artikelnummer: Cay22048-1
AM966 is an orally bioavailable, potent, and selective antagonist of the lysophosphatidic acid receptor 1 (LPA1) that has an IC50 value of 17 nM in a calcium assay using CHO cells transfected with the human LPA1 receptor. It is selective for LPA1 over the LPA2, LPA3, LPA4, and LPA5 receptors (IC50s = 1,700, 1,600,...
| Schlagworte: | 4'-[4-[[[(1R)-1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid |
| Anwendung: | LPAR1 antagonist |
| CAS | 1228690-19-4 |
| MW: | 490.9 D |
ab 71,00 €
Lipid-based Drug Delivery-Tools
1-Oleoyl-2-hydroxy-sn-glycero-3-PE
Artikelnummer: Cay25596-5
1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid...
| Schlagworte: | 18:1 LPE, 18:1 Lyso-PE, 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine,... |
| Anwendung: | Lysophospholipid |
| CAS | 89576-29-4 |
| MW: | 479.6 D |
ab 73,00 €
BMS 986020
Artikelnummer: Cay22049-1
BMS 986020 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, Kb = 0.0067 µM). It is selective for LPA1 over LPA3 in CHO cells expressing the human receptors (IC50s = 0.3 and >1 µM, respectively). BMS 986020 also inhibits organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, the bile salt export...
| Schlagworte: | 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-cyclopropanecarboxylic acid |
| Anwendung: | LPAR1 antagonist |
| CAS | 1257213-50-5 |
| MW: | 482.5 D |
ab 49,00 €
AM095
Artikelnummer: Cay22141-5
AM095 is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) with IC50 values of 25 and 23 nM in CHO cells expressing human or mouse receptors, respectively. It is selective for LPA1 over LPA2, LPA3, LPA4, and LPA5 (IC50s = >10,000 nM for human LPA2-5). It inhibits chemotaxis of CHO cells...
| Schlagworte: | 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid |
| Anwendung: | LPA1 antagonist |
| CAS | 1228690-36-5 |
| MW: | 456.5 D |
ab 122,00 €
1-Stearoyl-2-hydroxy-sn-glycero-3-PE
Artikelnummer: Cay25593-10
1-Stearoyl-2-hydroxy-sn-glycero-3-PE is a lysophospholipid. It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid receptor 1 (LPA1) receptor antagonist AM095 (Cay-22141).Formal Name:...
| Schlagworte: | 18:0 LPE, 18:0 Lyso PE, 1-Octadecanoyl-sn-glycero-3-phosphoethanolamine, 1-Stearoyl LPE, 1-Stearoyl lyso-PE,... |
| Anwendung: | Lysophospholipid |
| CAS | 69747-55-3 |
| MW: | 481.6 D |
ab 146,00 €
Human LPAR1 / LPA1 / EDG2 ELISA Kit
Artikelnummer: G-HUFI02151.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Oleoyl Ethanolamide Phosphate
Artikelnummer: Cay22886-1
Oleoyl ethanolamide phosphate (OEA-P) is a lysophosphatidic acid (LPA) mimetic, LPA receptor agonist, and phosphate ester of oleoyl ethanolamide (OEA, Cay-90265). It selectively increases [35S]GTPgammaS binding to HEK293T cell membranes expressing LPA1 and LPA2 over LPA3 receptors. OEA-P induces calcium mobilization...
| Schlagworte: | NAEPA, N-oleoyl ethanolamide phosphoric acid, OEA-P, N-[2-(phosphonooxy)ethyl]-9Z-octadecenamide |
| Anwendung: | Selective LPA1 receptor agonist |
| CAS | 24435-25-4 |
| MW: | 405.5 D |
ab 102,00 €
ONO-7300243
Artikelnummer: Cay22052-1
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, IC50 = 0.16 µM). It is selective for LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively). ONO-7300243 dose-dependently reduces intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg) without affecting mean...
| Schlagworte: | 4-[[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl]-benzeneacetic acid |
| Anwendung: | LPA1 antagonist |
| CAS | 638132-34-0 |
| MW: | 461.6 D |
ab 60,00 €