Zu "K04285" wurden 24 Artikel gefunden!
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5-Methoxycarbonylamino-N-acetyltryptamine
Artikelnummer: Cay39553-10
5-Methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) is a melatonin (Cay-14427) derivative and a partial agonist of melatonin receptor 1 (MT1) and MT2. It inhibits forskolin-induced production of cAMP in CHO cells expressing human MT1 or MT2 (EC50s = 440 and 98 nM, respectively). In vivo, ocular administration of...
| Schlagworte: | 5-MCA-NAT, GR135531, MCA-NAT, N-[3-[2-(acetylamino)ethyl]-1H-indol-5-yl]-carbamic acid, methyl ester |
| Anwendung: | Melatonin receptor MTNR1A/B partial agonist |
| CAS | 190277-13-5 |
| MW: | 275.3 D |
ab 54,00 €
Human MTNR1A (Melatonin Receptor 1A) ELISA Kit
Artikelnummer: ELK-ELK4335.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MTNR1A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MTNR1A....
| Schlagworte: | MTNR1A, Mel-1A-R, Mel1a receptor, Melatonin receptor type 1A |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Melatonin
Artikelnummer: Cay14427-5
Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes. Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3...
| Schlagworte: | NSC 113928, NSC 56423, Regulin, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Anwendung: | Neurohormone, Antioxidant |
| CAS | 73-31-4 |
| MW: | 232.3 D |
ab 43,00 €
Agomelatine
Artikelnummer: Cay13203-5
Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin (Cay-14427). It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPgammaS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of...
| Schlagworte: | S20098, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-acetamide |
| Anwendung: | Melatonin analog |
| CAS | 138112-76-2 |
| MW: | 243.3 D |
ab 102,00 €
Anti-MTNR1A
Artikelnummer: E-AB-12579.120
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length....
| Schlagworte: | Anti-MTNR1A, Anti-Mel-1A-R, Anti-Mel1a receptor, Anti-Melatonin receptor type 1A, MTNR1A Polyclonal Antibody |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Perlapine
Artikelnummer: Cay17756-10
Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADDs) derived from the human muscarinic acetylcholine M3...
| Schlagworte: | 6-(4-Methyl-1-piperazinyl)morphanthridine, NSC 291840, 6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine |
| Anwendung: | Melatonin receptor 1A/B agonist |
| CAS | 1977-11-3 |
| MW: | 291.4 D |
ab 77,00 €
Anti-MTNR1A, Internal
Artikelnummer: ARG64913.100
Protein function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. [The UniProt Consortium]
| Schlagworte: | Anti-MTNR1A, Anti-Mel-1A-R, Anti-Mel1a receptor, Anti-Melatonin receptor type 1A |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
2-Iodomelatonin
Artikelnummer: Cay19711-10
2-iodomelatonin is a potent agonist of melatonin receptor 1 (MT1, Ki = 28 pM) that is 5-fold selective for MT1 over MT2. It inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 30-fold more potently than melatonin (Cay-14427) with an EC50 value of 11 pM. 2-iodomelatonin has been used to...
| Schlagworte: | N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Anwendung: | Melatonin agonist |
| CAS | 93515-00-5 |
| MW: | 358.2 D |
ab 66,00 €
Ramelteon
Artikelnummer: Cay20389-10
Ramelteon is a melatonin (MT) receptor agonist (Kis = 14, 112, and 23.1 pM for human MT1, human MT2, and chick forebrain receptors, respectively). It is selective for MT1 and MT2 over MT3 receptors (Ki = 2.65 µM for hamster brain MT3 receptors) as well as a panel of benzodiazepine, dopamine, and opiate receptors,...
| Schlagworte: | TAK-375, N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]-propanamide |
| Anwendung: | Melatonin receptor agonist |
| CAS | 196597-26-9 |
| MW: | 259.3 D |
ab 125,00 €
Anti-Melatonin receptor
Artikelnummer: NSJ-R35964-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: MTNR1A, melatonin receptor 1A, MEL-1A-R, MT1 Protein function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this...
| Schlagworte: | Anti-MTNR1A, Anti-Mel-1A-R, Anti-Mel1a receptor, Anti-Melatonin receptor type 1A, Melatonin receptor Antibody |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
755,00 €
Melatonin Receptor Type 1A (human recombinant)
Artikelnummer: Cay24731-10
Melatonin receptor type 1A (MT1) (human recombinant) contains amino acids corresponding to the full length, wild-type human MT1 receptor, as well as N-terminal histidine and streptavidin tags with a TEV protease cleavage site. The MT1 receptor is encoded by the MTNR1A gene and is a G protein-coupled receptor...
| Schlagworte: | MTNR1A, Mel-1A-R, Mel-1A-R, Mel1a receptor, Mel1a receptor, Melatonin receptor type 1A, Melatonin receptor type 1A |
2.042,00 €
6-hydroxy Melatonin
Artikelnummer: Cay21857-10
6-hydroxy Melatonin is an active metabolite of melatonin (Cay-14427). It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC50 =...
| Schlagworte: | N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Anwendung: | Primary active melatonin metabolite |
| CAS | 2208-41-5 |
| MW: | 248.3 D |
ab 109,00 €