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Zu "K04259" wurden 48 Artikel gefunden!
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Artikelnummer: ELK-ELK5036.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human EP2. Next,...
Schlagworte: | PTGER2, Prostanoid EP2 receptor, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostaglandin E2 receptor EP2 subtype |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay15016-5
Prostaglandin E2 (PGE2) evokes distinct responses through four different 'E prostanoid' (EP) receptors. EP2 is a G protein-coupled receptor which signals preferentially through Gs proteins. PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM). It is over a thousand-fold less...
Schlagworte: | 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid |
Anwendung: | EP2 receptor antagonist |
CAS | 1078166-57-0 |
MW: | 409.4 D |
ab 131,00 €
Artikelnummer: Cay23444-1
TG6-10-1 is a potent antagonist of E prostanoid receptor 2 (EP2, Kb = 17.8 nM in C6 glioma cells overexpressing human EP2). It is 300-, 25-, and 10-fold selective for EP2 over other prostanoid receptors, including human EP3-4, FP and TP, and DP1 receptors, respectively. TG6-10-1 is also selective for EP2 over a...
Schlagworte: | (2E)-N-[2-[2-(trifluoromethyl)-1H-indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide |
Anwendung: | Prostaglandin E2 receptor EP2 antagonist |
CAS | 1415716-58-3 |
MW: | 448.4 D |
ab 50,00 €
Artikelnummer: Cay22945-1
CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively). It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (=30% inhibition at a concentration of 10 µM). CP 544,326...
Schlagworte: | 2-[3-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid |
Anwendung: | Prostaglandin receptor agonist |
CAS | 752187-80-7 |
MW: | 478.5 D |
ab 43,00 €
Artikelnummer: Cay17639-10
Prostaglandin E2 (PGE2) evokes distinct responses through four different 'E prostanoid' (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less...
Schlagworte: | (2E)-N-[2-(2-methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide |
Anwendung: | Brain penetrant EP2 antagonist |
CAS | 1164462-05-8 |
MW: | 394.5 D |
ab 84,00 €
Artikelnummer: Cay22693-50
tetranor-Misoprostol is a metabolite of misoprostol (Cay-13820). It is formed when misoprostol undergoes rapid de-esterification to form misoprostol (free acid) (Cay-13821), which is further metabolized to form the more polar tetranor-misoprostol in rats, dogs, and monkeys.Formal Name:...
Schlagworte: | 3-((1R,2R,3R)-3-hydroxy-2-((E)-4-hydroxy-4-methyloct-1-en-1-yl)-5-oxocyclopentyl)propanoic acid |
Anwendung: | Misoprostol metabolite |
MW: | 312.4 D |
ab 179,00 €
Artikelnummer: Cay19085-1
Prostaglandin E2 (PGE2, Cay-14010) evokes distinct responses through four different 'E prostanoid' (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation...
Schlagworte: | SID 17503974,... |
Anwendung: | EP2 receptor antagonist |
CAS | 1164464-14-5 |
MW: | 491.6 D |
ab 60,00 €
Artikelnummer: Cay30188-5
TG11-77 is a brain-permeable antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 (KB = 9.7 nM). It is selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 µM) inhibits the expression of genes encoding COX-2, IL-1beta, and IL-6 induced by...
Schlagworte: | 2-((4,6-dimethylpyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide, monohydrochloride |
Anwendung: | Prostanoid EP2 receptor antagonist |
CAS | 2550393-38-7 |
MW: | 436.9 D |
ab 125,00 €
Artikelnummer: Cay600340-1
The EP2 receptor is one of four GPCRs that mediate the actions of PGE2. The diverse effects of PGE2 acting via EP2 receptors point to the need to identify novel agonists and antagonists, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases. Cayman's EP2...
Schlagworte: | PGE2 Receptor 2, Prostaglandin E2 Receptor 2 |
Anwendung: | Reverse transfection reporter assay |
Spezies-Reaktivität: | rat |
621,00 €
Artikelnummer: Cay601380-96
Prostaglandin E2 (PGE2) is one of the most important biologically active prostanoids which exerts its actions mainly by binding to four distinct E-type prostanoid receptors: EP1, EP2, EP3, and EP4. These four G protein-coupled receptors (GPCRs) exhibit differences in signal transduction mechanisms, tissue...
Schlagworte: | PGE2 Receptor 2, Prostaglandin E2 Receptor 2 |
Anwendung: | Cell based assays, chemiluminescence, HTS, reverse transfection reporter assay |
621,00 €
Artikelnummer: NSJ-R32100
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Prostaglandin E2 receptor (53kDa), also known as EP2, is aprostaglandin receptor for prostaglandin E2. It is encoded by the human gene PTGER2. It may be associated with aspirin-induced asthma. PTGER2 is mapped to chromosome 14q22. This gene encodes a receptor...
Schlagworte: | Anti-PTGER2, Anti-Prostanoid EP2 receptor, Anti-PGE receptor EP2 subtype, Anti-PGE2 receptor EP2 subtype,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: E-AB-16732.120
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. Protein function: Receptor for prostaglandin E2 (PGE2). The activity of this...
Schlagworte: | Anti-PTGER2, Anti-Prostanoid EP2 receptor, Anti-PGE receptor EP2 subtype, Anti-PGE2 receptor EP2 subtype,... |
Anwendung: | WB, IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 71,00 €