Zu "K04259" wurden 60 Artikel gefunden!
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Evatanepag
Artikelnummer: Cay42727-1
Evatanepag is an agonist of prostaglandin E2 (PGE2) receptor subtype EP2. It induces cAMP accumulation in cells expressing rat EP2 (EC50 = 0. nM). Evatanepag (3 mg/kg) increases total bone area, mineral content, and mineral density in rat tibia.. Solulibility: DMSO: Sparingly soluble: 0.1-1 mg/ml: .
| Schlagworte: | CP 533,536, 2-[3-[[[[4-(1,1-dimethylethyl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid |
| Anwendung: | Prostaglandin E2 receptor (EP2) agonist |
| CAS | 223488-57-1 |
| MW: | 468.6 D |
ab 48,00 €
Evatanepag
Artikelnummer: TGM-T15259-100mg
Description: Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. Target: Prostaglandin...
| Schlagworte: | CP-533536 free acid |
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 223488-57-1 |
| MW: | 468.57 D |
ab 63,00 €
Omidenepag isopropyl
Artikelnummer: TGM-T16388-100mg
Description: Omidenepag isopropyl (DE-117) is a selective prostaglandin EP2 receptor agonist and a novel topical ocular blood pressure lowering compound.Omidenepag isopropyl has a weak affinity for EP1, EP2, and FP receptors.Omidenepag isopropyl is used in studies of glaucoma and hypertension. Omidenepag isopropyl...
| Schlagworte: | DE-117, DE117, DE 117 |
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 1187451-19-9 |
| MW: | 520.6 D |
ab 52,00 €
Omidenepag
Artikelnummer: TGM-T16389-1mg
Description: Omidenepag (UR-7276) is a selective and potent prostaglandin E2 receptor 2 (EP2) agonist and a novel topical ocular hypotensive agent.Omidenepag is used in the study of glaucoma and hypertension. Target: Prostaglandin Receptor. Smiles: OC(=O)CNc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)n1....
| Schlagworte: | UR-7276 |
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 1187451-41-7 |
| MW: | 478.52 D |
69,00 €
Taprenepag isopropyl
Artikelnummer: TGM-T16988-2mg
Description: Taprenepag isopropyl is a highly selective agonist of the EP2 receptor. Target: Prostaglandin Receptor. Smiles: CC(C)OC(=O)COc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)c1. References: Yanochko GM, et al. Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in...
| Schlagworte: | PF-04217329 |
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 1005549-94-9 |
| MW: | 520.6 D |
48,00 €
TG6-129
Artikelnummer: TGM-T28958-100mg
Description: TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1beta, IL-6, IL-12, IL-23 and TNF-alpha induced by the EP2-selective agonist butaprost in P388D1 macrophages....
| Schlagworte: | TG6 129 |
| Anwendung: | EP2 receptor antagonist |
| CAS | 1164464-14-5 |
| MW: | 491.58 D |
ab 122,00 €
PF-04418948
Artikelnummer: TGM-T3306-100mg
Description: PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors, exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 µM. Inhibits PGE2-induced...
| Schlagworte: | PF 04418948, PF04418948 |
| Anwendung: | EP2 receptor antagonist |
| CAS | 1078166-57-0 |
| MW: | 409.41 D |
ab 42,00 €
Prostaglandin E2
Artikelnummer: TGM-T5014-100mg
Description: Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in various physiological processes, such as smooth muscle contraction and relaxation, vasodilation and constriction, blood pressure regulation, and inflammatory regulation. Target: Endogenous Metabolite, Prostaglandin Receptor. Smiles:...
| Schlagworte: | PGE2, Dinoprostone, Prostaglandin E2 (PGE2) |
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 363-24-6 |
| MW: | 352.47 D |
ab 37,00 €
TG4-155
Artikelnummer: TGM-T5482-100mg
Description: TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. Target: Prostaglandin Receptor. Smiles: COc1cc(\C=C\C(=O)NCCn2c(C)cc3ccccc23)cc(OC)c1OC. References: Jiang J , Ganesh T , Du Y , et al. Small...
| Anwendung: | Brain penetrant EP2 antagonist |
| CAS | 1164462-05-8 |
| MW: | 394.46 D |
ab 31,00 €
Evatanepag sodium
Artikelnummer: TGM-T69755-100mg
Description: Evatanepag, also known as CP-533536, is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. Target: Others. Smiles:...
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 223490-49-1 |
| MW: | 490.55 D |
ab 1.520,00 €
Arbaprostil
Artikelnummer: TGM-T71801-1mg
Description: Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors....
| Anwendung: | Targets prostaglandin E receptor 2 (PTGER2) |
| CAS | 55028-70-1 |
| MW: | 366.49 D |
392,00 €
TG11-77 hydrochloride
Artikelnummer: TGM-T85023-10mg
Description: TG11-77 hydrochloride is a potent, selective, and water-soluble EP2 receptor antagonist that is brain-permeable, demonstrating a KB value of 9.7 nM. Target: Others. Smiles: C(CNC(=O)C=1C=NC(NC2=CC(C)=CC(C)=N2)=NC1)C=3C=4C(NC3C)=CC=CC4.Cl
| Anwendung: | Prostanoid EP2 receptor antagonist |
| CAS | 2550393-38-7 |
| MW: | 436.94 D |
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