Zu "K04234" wurden 42 Artikel gefunden!
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PAR2 (1-6) amide (human) (trifluoroacetate salt)
Artikelnummer: TGM-T35955-10mg
Description: PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 µM in a...
| Schlagworte: | PAR2 (1-6) amide (human) (trifluoroacetate salt) |
| Anwendung: | PAR2 peptide agonist |
| CAS | 2379569-17-0 |
| MW: | 728.812 D |
ab 154,00 €
PAR2 (1-6) (mouse, rat)
Artikelnummer: TGM-T36531-10mg
Description: PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6)...
| Schlagworte: | PAR2 (1-6) (mouse, rat) |
| Anwendung: | Synthetic peptide PAR2 agonist |
| CAS | 164081-25-8 |
| MW: | 657.814 D |
ab 108,00 €
I-191
Artikelnummer: TGM-T7137-100mg
Description: I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells. Target: Protease-activated Receptor. Smiles: CC(C)(C)c1cc(nn2cc(nc12)C(=O)N1CCNC(=O)C1(C)C)-c1ccc(F)cc1. References: Jiang Y , Yau M K , Lim J , et al. A potent antagonist...
| Anwendung: | PAR2 antagonist |
| CAS | 1690172-25-8 |
| MW: | 423.48 D |
ab 81,00 €
AZ3451
Artikelnummer: TGM-TQ0012-100mg
Description: AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM). Target: Protease-activated Receptor. Smiles: C[C@@H](C1CCCCC1)n1c(nc2cc(ccc12)C(=O)Nc1ccc(cc1)C#N)-c1cc2OCOc2cc1Br. References: Cheng RKY, et al. Structural insight into allosteric modulation of protease-activated...
| Anwendung: | Allosteric PAR2 antagonist |
| CAS | 2100284-59-9 |
| MW: | 571.46 D |
ab 40,00 €
FSLLRY-NH2
Artikelnummer: TGM-TP1904-10mg
Description: Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. References: McLarty et...
| Anwendung: | PAR2 antagonist |
| CAS | 245329-02-6 |
| MW: | 796.97 D |
ab 222,00 €
SLIGRL-NH2 (trifluoroacetate salt)
Artikelnummer: Cay16723-1
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand. The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2). SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM),...
| Schlagworte: | L-seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-Leucinamide, trifluoroacetate salt |
| Anwendung: | PAR-2 activator |
| MW: | 656.8 D |
ab 52,00 €
Human F2RL1 Protein, hFc Tag
Artikelnummer: DIM-PME101118.10
Recombinant human F2RL1 protein with C-terminal human Fc tag. F2RL1(Ser37-Gly71) hFc(Glu99-Ala330), Protein function: Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC),...
| Schlagworte: | GPR11, PAR2 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 29.7 kD |
ab 148,00 €
F2RL1 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100036.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | GPR11, F2RL1, GPR11, PAR2, Human F2RL1 full length protein-synthetic nanodisc |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 44.1 kD |
ab 1.291,00 €
FSLLRY-amide
Artikelnummer: Cay14709-5
FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 µM) but not by the synthetic agonist SLIGRL-NH2 (Cay-16723). It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein. It can be used to study PAR2 action...
| Schlagworte: | L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide |
| Anwendung: | PAR2 antagonist |
| CAS | 245329-02-6 |
| MW: | 797 D |
ab 122,00 €
AC-55541
Artikelnummer: Cay17736-5
AC-55541 is a proteinase-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization in in vitro functional assays (pEC50s = 6.7,...
| Schlagworte: | alpha-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid 2E-[1-(3-bromophenyl)ethylidene]hydrazide |
| Anwendung: | PAR2 agonist |
| CAS | 916170-19-9 |
| MW: | 518.4 D |
ab 61,00 €
2-furoyl-LIGRLO amide (trifluoroacetate salt)
Artikelnummer: Cay14594-1
2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0). It does not activate PAR1 or PAR4. Through its effects on PAR2, 2-furoyl-LIGRLO amide produces a concentration-dependent relaxation of arteries previously contracted with alpha1 adrenergic receptor...
| Schlagworte: | N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide, trifluoroacetate |
| Anwendung: | PAR2 agonist |
| MW: | 778 D |
159,00 €
Mouse PAR2 / Protease Activated Receptor 2 ELISA Kit
Artikelnummer: G-MOFI01027.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
694,00 €