Zu "K04222" wurden 83 Artikel gefunden!
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Tradipitant
Artikelnummer: Cay41831-1
Tradipitant is a neurokinin-1 (NK1) receptor antagonist (Ki = =100 nM).Formal Name: [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)-methanone. CAS Number: 622370-35-8. Synonyms: LY686017, VLY-686. Molecular Formula: C28H16ClF6N5O. Formula Weight:...
| Schlagworte: | LY686017, VLY-686,... |
| Anwendung: | Substance-P receptor (NK-1 receptor, Tachykinin receptor 1) antagonist |
| CAS | 622370-35-8 |
| MW: | 587.9 D |
ab 54,00 €
Aprepitant
Artikelnummer: TGM-T1743-50mg
Description: Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer. Target: Neurokinin receptor, HIV Protease,...
| Schlagworte: | Aprepitant`, MK-0869, L-754030, MK-869 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 170729-80-3 |
| MW: | 534.43 D |
ab 48,00 €
Rolapitant hydrochloride hydrate
Artikelnummer: TGM-T68371-100mg
Description: Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous...
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 914462-92-3 |
| MW: | 554.95 D |
ab 2.573,00 €
Netupitant
Artikelnummer: TGM-T6905-100mg
Description: Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM). Target: Neurokinin receptor. Smiles: CN(C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnc(cc1-c1ccccc1C)N1CCN(C)CC1. References: Rizzi A, et al. Peptides. 2012, 37(1):86-97.
| Schlagworte: | Ro 67-31898/000, CID 6451149 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 290297-26-6 |
| MW: | 578.59 D |
ab 46,00 €
Orvepitant
Artikelnummer: TGM-T69063-100mg
Description: Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia. Target: Others. Smiles: C(N([C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C)(=O)N2[C@H](C[C@H](CC2)N3C[C@]4(N(CC3)C(=O)CC4)[H])C5=C(C)C=C(F)C=C5
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 579475-18-6 |
| MW: | 628.62 D |
ab 2.573,00 €
WIN 66306
Artikelnummer: TGM-T71935-100mg
Description: WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner. Target: Others. Smiles:...
| Anwendung: | TACR1 / TACR2 peptide antagonist |
| CAS | 151928-32-4 |
| MW: | 800.9 D |
ab 2.573,00 €
Vestipitant mesylate
Artikelnummer: TGM-T69419-100mg
Description: Vestipitant mesylate is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utility of NK(1) receptor blockade in the alleviation of anxiety and, possibly, depression. It is under...
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 334476-64-1 |
| MW: | 587.55 D |
ab 1.671,00 €
Fosnetupitant chloride monohydrochloride
Artikelnummer: TGM-T78104-50mg
Description: Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for the NK3 receptor with a pK i of 6.1. It serves as a methylene phosphate prodrug of...
| Schlagworte: | Pronetupitant chloride monohydrochloride |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 1643757-72-5 |
| MW: | 761.52 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
L-732138
Artikelnummer: TGM-T8235-100mg
Description: L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM). Target: Neurokinin receptor. Smiles: CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F. References: Muñoz M, et al. The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts...
| Anwendung: | NK1 receptor antagonist |
| CAS | 148451-96-1 |
| MW: | 472.38 D |
ab 31,00 €
TACR1 Protein, Human, Recombinant (GST)
Artikelnummer: TGM-TMPH-02147-100ug
Description: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. TACR1 Protein, Human,...
| Schlagworte: | TACR1, Substance-P receptor, Tachykinin receptor 1, NK-1 receptor |
| MW: | 30.1 kD |
ab 198,00 €
Substance P TFA
Artikelnummer: TGM-TP2155-100mg
Description: Substance P TFA (Neurokinin P TFA) is a neuropeptide that functions as both a neurotransmitter and neuromodulator in the central nervous system, specifically targeting the neurokinin 1 receptor (NK1-receptor, NK1R). Target: Others. Smiles:...
| Schlagworte: | Neurokinin P TFA |
| Anwendung: | Endogenous TACR1 ligand, neuropeptide |
| CAS | 148470-19-3 |
| MW: | 1461.67 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
Fosaprepitant dimeglumine
Artikelnummer: TGM-T1790-100mg
Description: Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P/neurokinin 1 (NK1)...
| Schlagworte: | MK-0517, Fosaprepitant dimeglumine salt, L785298 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 265121-04-8 |
| MW: | 1004.83 D |
ab 45,00 €