Zu "K04222" wurden 107 Artikel gefunden!
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NEU
Maropitant (citrate)
Artikelnummer: Cay45625-10
Maropitant is a neurokinin-1 (NK1) receptor antagonist. It reduces motion sickness- or doxorubicin-induced emesis in dogs. Formulations containing maropitant have been used as antiemetics in dogs.. SMILES: OC(CC(C(O)=O)(O)CC(O)=O)=O.COC(C=CC(C(C)(C)C)=C1)=C1CN[C@@H](C2CCN3CC2)[C@@H]3C(C4=CC=CC=C4)C5=CC=CC=C5. InChi...
| Schlagworte: | (2S,3S)-N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine,... |
| Anwendung: | NK1 receptor antagonist |
| CAS | 862543-54-2 |
| MW: | 660.81 D |
ab 83,00 €
NEU
Anti-Recombinant NK-1R, clone C171937
Artikelnummer: E-AN302317L.100
Protein function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K [The UniProt...
| Schlagworte: | Anti-TACR1, Anti-NK-1 receptor, Anti-Substance-P receptor, Anti-Tachykinin receptor 1, Recombinant NK-1R Monoclonal Antibody |
| Anwendung: | WB, IF, IP, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
TACR1 (NK1R)/NFAT Luciferase Reporter HEK293 Cell Line
Artikelnummer: BPS-84168
TACR1 (NK1R)/NFAT Luciferase Reporter HEK293 Cell Line is a HEK293 cell line stably expressing full-length human Tachykinin Receptor 1 (TACR1, also known as neurokinin receptor NK1R, accession number: NM_001058.3), and a firefly luciferase reporter under the control of NFAT (nuclear factor of activated T cells)...
| Schlagworte: | TACR1, Substance-P receptor, NK-1 receptor, Tachykinin receptor 1 |
| Anwendung: | Activator/inhibitor screening, drug discovery, NK1R antibody/antagonist/agonists characterization |
| Spezies-Reaktivität: | human |
16.117,00 €
Substance P-d10 (trifluoroacetate salt)
Artikelnummer: Cay44814-1
An internal standard for the quantification of substance P by GC- or LC-MS. SMILES:...
| Schlagworte: | SP-d10,... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, NK1 receptor agonist |
| MW: | 1357.71 D |
ab 105,00 €
Hemokinin 1-d10 (human) (trifluoroacetate salt)
Artikelnummer: Cay44813-1
An internal standard for the quantification of hemokinin 1 by GC- or LC-MS. SMILES:...
| Schlagworte: | HK-1-d10, Tachykinin-4 (57-67)-d10,... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, NK1 receptor agonist |
| MW: | 1195.47 D |
ab 383,00 €
Anti-NKR1 / Neurokinin 1 Receptor / TACR1, clone AFBH-20
Artikelnummer: NSJ-FY12839
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. NKR1 antibody detects Neurokinin 1 receptor, a G protein-coupled receptor (GPCR) encoded by the TACR1 gene on chromosome 2p12 that mediates the biological effects of the neuropeptide Substance P. This...
| Schlagworte: | Anti-TACR1, Anti-NK-1 receptor, Anti-Substance-P receptor, Anti-Tachykinin receptor 1, NKR1 Antibody / Neurokinin 1... |
| Anwendung: | IP, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Aprepitant
Artikelnummer: TGM-T1743-50mg
Description: Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer. Target: Neurokinin receptor, HIV Protease,...
| Schlagworte: | Aprepitant`, MK-0869, L-754030, MK-869 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 170729-80-3 |
| MW: | 534.43 D |
ab 46,00 €
Aprepitant
Artikelnummer: Cay14867-5
Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM, IC50 = 0.09 nM for the human receptor). It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3). In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P...
| Schlagworte: | Emend, L-754,030, MK-869, ONO-7436,... |
| Anwendung: | NK-1 receptor antagonist |
| CAS | 170729-80-3 |
| MW: | 534.4 D |
ab 58,00 €
Netupitant
Artikelnummer: Cay23809-25
Netupitant is an insurmountable antagonist of the neurokinin-1 (NK1) receptor (Ki = 0.95 nM in CHO cells expressing the human recombinant receptor). It is selective for human NK1 over human NK2 and NK3 and rat NK1 (Kis = >1,500 nM) and over 50 G protein-coupled receptors, monoamine transporters, and ion channels...
| Schlagworte: | Ro 67-31898/000,... |
| Anwendung: | Neurokinin NK1 antagonist |
| CAS | 290297-26-6 |
| MW: | 578.6 D |
ab 137,00 €
Substance P (trifluoroacetate salt)
Artikelnummer: Cay24035-5
Substance P is tachykinin neuropeptide that selectively binds to neurokinin 1 (NK1) receptors (Kis = 0.14 and 300 nM for NK1 and NK3, respectively) and has diverse biological activities. It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system and in...
| Schlagworte: | substance p, trifluoroacetate salt |
| Anwendung: | Endogenous TACR1 ligand, neuropeptide |
| CAS | 148470-19-3 |
| MW: | 1347.6 D |
ab 69,00 €
rac-Aprepitant-d4
Artikelnummer: Cay25232-1
rac-Aprepitant-d4 is intended for use as an internal standard for the quantification of aprepitant (Cay-14867) by GC- or LC-MS. Aprepitant an antiemetic compound and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM, IC50 = 0.09 nM for the human receptor). It is selective for NK1 over NK3 receptors (Ki =...
| Schlagworte: | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl-2,3,5,6-d4)morpholino)methyl)-2,4-dihydro-3... |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 2748471-42-1 |
| MW: | 538.5 D |
ab 361,00 €
Rolapitant
Artikelnummer: Cay23906-10
Rolapitant is a potent neurokinin-1 (NK1) receptor antagonist (Ki = 0.66 nM for the human receptor). It is greater than 1,000-fold selective for NK1 over NK2 and NK3 and lacks activity in a panel of 100 receptors, transporters, enzymes, and ion channels. Rolapitant inhibits GR-73632-induced calcium efflux in CHO...
| Schlagworte: | (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one |
| Anwendung: | Antiemetic, neurokinin NK1 antagonist |
| CAS | 552292-08-7 |
| MW: | 500.5 D |
ab 51,00 €