Zu "K04213" wurden 56 Artikel gefunden!
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CHO-K1/OPRD1/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00323
Recombinant CHO-K1 cells stably overexpress human opioid receptor delta 1 (OPRD1) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.
| Schlagworte: | OPRD1, Delta-type opioid receptor |
11.424,00 €
DPDPE (trifluoroacetate salt)
Artikelnummer: Cay23184-1
DPDPE is a synthetic enkephalin peptide and an agonist of delta1-opioid receptors (Ki = 2.7 nM for the rat receptors). It is selective for delta-opioid receptors over µ- and kappa-opioid receptors (Kis = 713 and >1,500 nM, respectively, for the rat receptors). In vivo, DPDPE (4.5 nmol i.c.v.) increases the latency...
| Schlagworte: | [D-Pen2,D-Pen5]Enkephalin, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2->5)-disulfide,... |
| Anwendung: | Synthetic enkephalin peptide, delta-opioid receptor agonist |
| MW: | 645.8 D |
ab 93,00 €
Naltriben (mesylate)
Artikelnummer: Cay38979-1
Naltriben is an inverse agonist of delta2-opioid receptors (Ki = 0.013 nM in CHO-DG44 cells expressing the mouse receptor). It is selective for delta2-opioid receptors over kappa- and µ-opioid receptors (Kis = 13 and 12 nM in PC12 and COS-7 cells expressing the mouse and rat receptors, respectively). Naltriben (1...
| Schlagworte: | NIH 10924, NTB,... |
| Anwendung: | delta-opioid receptor subtype 2 inverse agonist |
| CAS | 122517-78-6 |
| MW: | 511.6 D |
ab 71,00 €
SNC 80
Artikelnummer: Cay15599-5
SNC 80 is a selective nonpeptide agonist of the delta-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the µ-opioid receptor. It effectively activates µ/delta receptor heteromers (EC50 = 52.8 nM) but not kappa/delta or µ/kappa heteromers. SNC 80 has antinociceptive as well as...
| Schlagworte: | NIH 10815, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-benzamide |
| Anwendung: | delta-opioid receptor agonist |
| CAS | 156727-74-1 |
| MW: | 449.6 D |
ab 102,00 €
BNTX (maleate)
Artikelnummer: Cay39829-1
BNTX is a delta1-opioid receptor antagonist (Ki = 0.1 nM). It is selective for the delta1-opioid receptor over the delta2-, µ-, and kappa-opioid receptors (Kis = 10.8, 13.3, and 58.6 nM, respectively). BNTX (1 and 10 µM) decreases proliferation of primary mouse splenic B cells and the production of IL-2 and IL-4 by...
| Schlagworte: | 7-Benzylidenenaltrexone, (5alpha,7E)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-morphinan-6-one,... |
| Anwendung: | Delta1-opioid receptor antagonist |
| CAS | 864461-31-4 |
| MW: | 545.6 D |
ab 52,00 €
SCH 202676 (hydrobromide)
Artikelnummer: Cay16945-10
SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs). It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors. It displays IC50 values of 0.1 to 1.8 µM for modulating...
| Schlagworte: | N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-methanamine, monohydrobromide |
| Anwendung: | GPCR antagonist / agonist binding inhibitor |
| CAS | 265980-25-4 |
| MW: | 348.3 D |
ab 93,00 €
ML-335
Artikelnummer: Cay15196-25
The µ-opioid receptor (OPRM1) is the primary site of action for morphine and other opioids associated with the treatment of pain. The occupancy of delta-opioid receptors (OPRD1) by antagonists has been shown to enhance OPRM1 binding and signaling activity. Because heteromerization of OPRM1 and OPRD1 is thought to be...
| Schlagworte: | CID-23723457, CYM 51010, 1-[[4-(acetylamino)phenyl]methyl]-4-(2-phenylethyl)-4-piperidinecarboxylic acid, ethyl ester |
| Anwendung: | OPRM1-OPRD1 heterodimerization agonist |
| CAS | 1069498-96-9 |
| MW: | 408.5 D |
ab 67,00 €
BMS 986187
Artikelnummer: Cay21549-1
BMS 986187 is a positive allosteric modulator of delta-opioid receptors. In the presence of the endogenous delta-opioid receptor agonist leu-enkephalin, BMS 986187 has an average EC50 value of 30 nM for beta-arrestin recruitment, but has little to no activity in the absence of an agonist. It is 100-fold selective...
| Schlagworte: | 3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione |
| Anwendung: | Selective positive allosteric delta-opioid Receptor modulator |
| CAS | 684238-37-7 |
| MW: | 470.6 D |
ab 49,00 €
SNC80
Artikelnummer: AG-CR1-0017-M005
Highly selective and potent non-peptide delta-opioid receptor agonist, Mediates downregulation of the delta-opioid receptor, Shows antidepressant-like effects, Modulates voltage-dependent sodium channels, Antinociceptive, Activates ATP-sensitive K channels, Enhances amphetamine-mediated dopamine efflux.
| Schlagworte: | (+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide |
| Anwendung: | delta-opioid receptor agonist |
| CAS | 156727-74-1 |
| MW: | 449,6 D |
ab 77,00 €
BMS 986188
Artikelnummer: Cay21548-1
BMS 986188 is a positive allosteric modulator of delta-opioid receptors, with an EC50 value of 0.05 µM in a beta-arrestin recruitment assay in the presence, but not absence, of the opioid receptor agonist leu-enkephalin (Cay-23283). It is selective for delta- over µ-opioid receptors (EC50 = >10 µM) in the presence...
| Schlagworte: | 9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8(2H)-dione |
| Anwendung: | Selective positive allosteric delta-opioid Receptor modulator |
| CAS | 1776115-10-6 |
| MW: | 535.5 D |
ab 40,00 €
Leu-Enkephalin (trifluoroacetate salt)
Artikelnummer: Cay23283-10
Leu-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of delta- and µ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively). It is selective for delta- and µ- over kappa-opioid receptors (Ki = >1,000 nM). Leu-Enkephalin is a cleavage product of proenkephalin, which is found primarily in...
| Schlagworte: | [Leu5]enkephalin, Leucine enkephalin, NSC 350588, Tyr-Gly-Gly-Phe-Leu-OH, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine |
| Anwendung: | Endogenous neuropeptide, delta-opioid receptor agonist, µ-opioid receptor agonist |
| CAS | 73563-78-7 |
| MW: | 669.7 D |
ab 67,00 €
Anti-OPRD1 / Delta Opioid Receptor
Artikelnummer: ARG41516.100
Protein function: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as...
| Schlagworte: | Anti-OPRD, Anti-DOR-1, Anti-OPRD1, Anti-D-OR-1, Anti-Delta-type opioid receptor |
| Anwendung: | FC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
658,00 €