Zu "K04211" wurden 37 Artikel gefunden!
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Meclinertant
Artikelnummer: TGM-T16034-100mg
Description: Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders. Target: Neurotensin Receptor. Smiles: O=C(O)C1(NC(=O)C2=NN(C=3C=CN=C4C=C(Cl)C=CC43)C(=C2)C=5C(OC)=CC=CC5OC)C6CC7CC(C6)CC1C7. References: Jolas...
| Schlagworte: | SR 48692 |
| Anwendung: | NTSR1 antagonist |
| CAS | 146362-70-1 |
| MW: | 587.07 D |
ab 77,00 €
SBI-553
Artikelnummer: TGM-T16860-100mg
Description: SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 µM). Target: Neurotensin Receptor. Smiles: COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1. References: Pinkerton AB, et al. Discovery of beta-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin...
| Anwendung: | beta-arrestin-biased positive allosteric NTSR1 modulator |
| CAS | 1849603-72-0 |
| MW: | 450.55 D |
ab 97,00 €
Human NTSR1 Protein, hFc Tag
Artikelnummer: DIM-PME101460.10
Recombinant human NTSR1 Protein with C-terminal human Fc tag. NTSR1(Met1-Thr67) hFc(Glu99-Ala330), Protein function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a...
| Schlagworte: | NTR |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 32.9 kD |
ab 129,00 €
NTSR1 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100131.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | NTRR, NTR1, NTRH, NTSR1, NT-R-1, Neurotensin receptor type 1, High-affinity levocabastine-insensitive neurotensin... |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 46.1 kD |
ab 1.291,00 €
Anti-NTSR1
Artikelnummer: CSB-PA248420.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NTSR1. Antigen Species: Human
| Schlagworte: | Anti-NTR1, Anti-NTRR, Anti-NTRH, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-NTSR1
Artikelnummer: CSB-PA917935.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NTSR1. Antigen Species: Human
| Schlagworte: | Anti-NTR1, Anti-NTRR, Anti-NTRH, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
ML-314
Artikelnummer: Cay19550-1
ML-314 is a neurotensin-1 receptor (NTS1) agonist. It is selective for NTS1 over NTS2 in a cell-based assay of receptor/beta-arrestin complex formation (EC50s = 2 and >80 µM, respectively) but is inactive in an NTS1 calcium flux assay (EC50 = >80 µM) indicating that, in contrast to other NTS1 agonists, it does not...
| Schlagworte: | 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]-quinazoline |
| Anwendung: | NTR1 agonist |
| CAS | 1448895-09-7 |
| MW: | 420.5 D |
ab 57,00 €
SBI-553
Artikelnummer: Cay36782-10
SBI-553 is a beta-arrestin-biased positive allosteric modulator (PAM) of neurotensin receptor 1 (NTSR1). It binds to NSTR1 and increases neurotensin-1 affinity for NSTR1 in HEK293 cells expressing the human receptor when used at concentrations ranging from 0.01 to 10 µM. SBI-553 (0.03-30 µM) induces beta-arrestin...
| Schlagworte: | 2-[[2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)-1-piperidinyl]-6-quinazolinyl]methylamino]-ethanol |
| Anwendung: | beta-arrestin-biased positive allosteric NTSR1 modulator |
| CAS | 1849603-72-0 |
| MW: | 450.6 D |
ab 40,00 €
SR 48692
Artikelnummer: Cay20124-1
SR 48692 is an orally bioavailable allosteric antagonist of the neurotensin receptor NTS1 (Kd = 3.4 nM). SR 48692 inhibits high affinity neurotensin binding to brain tissue from guinea pig, newborn mouse, newborn human, and adult human as well as rat mesencephalic cells and HT-29 cells with IC50 values ranging from...
| Schlagworte: | 2-[[[1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carbox... |
| Anwendung: | NTSR1 antagonist |
| CAS | 146362-70-1 |
| MW: | 587.1 D |
ab 44,00 €
Anti-NTSR1
Artikelnummer: E-AB-12597.120
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Protein function: G-protein coupled receptor for the...
| Schlagworte: | Anti-NTRH, Anti-NTRR, Anti-NTR1, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Neurotensin, frog
Artikelnummer: LKT-N1994.500
Endogenous neuropeptide involved in hormone release, NTS agonist.
| Anwendung: | Endogenous neuropeptide, NTS agonist |
| MW: | 1550.84 D |
ab 68,00 €
SR 142948 (hydrochloride)
Artikelnummer: Cay23911-1
SR 142948 is an orally bioavailable non-peptide antagonist of neurotensin receptors (NTS, IC50s = 1.19, 0.32, and 3.96 nM for human recombinant NTS receptors expressed in CHO cells, HT-29 cells, and adult rat brain membranes, respectively). It inhibits inositol phosphate formation in HT-29 cells (IC50 = 3.9 nM) and...
| Schlagworte: | 2-[[[5-(2,6-dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-y... |
| Anwendung: | NTSR1 antagonist |
| MW: | 758.8 D |
ab 128,00 €