Zu "K04211" wurden 39 Artikel gefunden!
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SBI-810
Artikelnummer: Cay45376-1
A beta-arrestin-2-biased positive allosteric modulator of the NTS1 receptor, increases neurotensin-1-induced beta-arrestin-2 recruitment to human NTS1 receptors in HEK293T cells (EC50 = 98 nM), increases the paw withdrawal threshold in mouse models of postoperative, neuropathic, and inflammatory pain at 12 mg/kg,...
| Schlagworte: | 2-[[4-[4-(2-methoxyphenyl)-1-piperidinyl]-2-(1-methylcyclopropyl)-6-quinazolinyl]methylamino]-ethanol |
| Anwendung: | beta-arrestin-2-biased positive allosteric neurotensin receptor 1 (NTSR1) modulator |
| CAS | 1849603-79-7 |
| MW: | 446.6 D |
ab 69,00 €
SBI-810 (hydrochloride)
Artikelnummer: Cay45322-1
SBI-810 is a beta-arrestin-2-biased positive allosteric modulator of neurotensin receptor 1 (NTS1). It increases neurotensin-1-induced beta-arrestin-2 recruitment to human NTS1 receptors in HEK293T cells (EC50 = 98 nM).2 SBI-810 (12 mg/kg) increases the paw withdrawal threshold in mouse models of postoperative,...
| Schlagworte: | 2-[[4-[4-(2-methoxyphenyl)-1-piperidinyl]-2-(1-methylcyclopropyl)-6-quinazolinyl]methylamino]-ethanol, dihydrochloride |
| Anwendung: | beta-arrestin-2-biased NTS1 receptor positive allosteric modulator |
| MW: | 484.06 D |
ab 55,00 €
ML-314
Artikelnummer: Cay19550-1
ML-314 is a neurotensin-1 receptor (NTS1) agonist. It is selective for NTS1 over NTS2 in a cell-based assay of receptor/beta-arrestin complex formation (EC50s = 2 and >80 µM, respectively) but is inactive in an NTS1 calcium flux assay (EC50 = >80 µM) indicating that, in contrast to other NTS1 agonists, it does not...
| Schlagworte: | 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]-quinazoline |
| Anwendung: | NTR1 agonist |
| CAS | 1448895-09-7 |
| MW: | 420.5 D |
ab 65,00 €
SR 48692
Artikelnummer: Cay20124-1
SR 48692 is an orally bioavailable allosteric antagonist of the neurotensin receptor NTS1 (Kd = 3.4 nM). SR 48692 inhibits high affinity neurotensin binding to brain tissue from guinea pig, newborn mouse, newborn human, and adult human as well as rat mesencephalic cells and HT-29 cells with IC50 values ranging from...
| Schlagworte: | 2-[[[1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carbox... |
| Anwendung: | NTSR1 antagonist |
| CAS | 146362-70-1 |
| MW: | 587.1 D |
ab 51,00 €
Anti-NTSR1
Artikelnummer: E-AB-12597.120
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Protein function: G-protein coupled receptor for the...
| Schlagworte: | Anti-NTRH, Anti-NTRR, Anti-NTR1, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Neurotensin, frog
Artikelnummer: LKT-N1994.500
Endogenous neuropeptide involved in hormone release, NTS agonist.
| Anwendung: | Endogenous neuropeptide, NTS agonist |
| MW: | 1550.84 D |
ab 68,00 €
SR 142948 (hydrochloride)
Artikelnummer: Cay23911-1
SR 142948 is an orally bioavailable non-peptide antagonist of neurotensin receptors (NTS, IC50s = 1.19, 0.32, and 3.96 nM for human recombinant NTS receptors expressed in CHO cells, HT-29 cells, and adult rat brain membranes, respectively). It inhibits inositol phosphate formation in HT-29 cells (IC50 = 3.9 nM) and...
| Schlagworte: | 2-[[[5-(2,6-dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-y... |
| Anwendung: | NTSR1 antagonist |
| MW: | 758.8 D |
ab 144,00 €
Anti-Neurotensin Receptor 1
Artikelnummer: ARG40524.100
Protein function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects...
| Schlagworte: | Anti-NTR1, Anti-NTRH, Anti-NTRR, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
707,00 €
Anti-Neurotensin Receptor 1
Artikelnummer: ARG66559.100
Protein function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects...
| Schlagworte: | Anti-NTR1, Anti-NTRH, Anti-NTRR, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
658,00 €
Anti-NTSR1 / Neurotensin Receptor 1
Artikelnummer: NSJ-RQ6923
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension,...
| Schlagworte: | Anti-NTR1, Anti-NTRH, Anti-NTRR, Anti-NTSR1, Anti-NT-R-1, Anti-Neurotensin receptor type 1, Anti-High-affinity... |
| Anwendung: | WB, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Human NTSR1 (Neurotensin Receptor 1, High Affinity) ELISA...
Artikelnummer: ELK-ELK4586.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NTSR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NTSR1. Next,...
| Schlagworte: | NTR1, NTRH, NTRR, NTSR1, NT-R-1, Neurotensin receptor type 1, High-affinity levocabastine-insensitive neurotensin receptor |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Mouse NTSR1 (Neurotensin Receptor 1, High Affinity) ELISA...
Artikelnummer: ELK-ELK7200.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse NTSR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse NTSR1. Next,...
| Schlagworte: | NTR1, Ntsr, Ntsr1, NT-R-1, Neurotensin receptor type 1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 374,00 €