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Zu "K04202" wurden 22 Artikel gefunden!
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Artikelnummer: Cay35175-10
PT-141 is a cyclic peptide agonist of melanocortin receptor 4 (MC4R) and an analog of alpha-melanocyte stimulating hormone (alpha-MSH, Cay-29923). It binds to MC3R and MC4R and increases intracellular cAMP levels in HEK293 cells expressing MC4R. It increases dopamine release in the medial preoptic area (mPOA) of the...
Schlagworte: | Bremelanotide Acetate, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine... |
Anwendung: | MC4R cyclic peptide agonist |
CAS | 1607799-13-2 |
MW: | 1085.2 D |
ab 77,00 €
Artikelnummer: Cay10006355-1
Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'. These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors,...
Schlagworte: | Anti-Mc4r, Anti-MC4-R, Anti-MC4-R, Anti-Melanocortin receptor 4, Anti-Melanocortin receptor 4 |
Anwendung: | IHC (paraffin), WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | mouse |
422,00 €
Artikelnummer: Cay35564-10
Setmelanotide is a cyclic peptide agonist of melanocortin receptor 4 (MC4R). It increases cAMP production in CHO-K1 cells expressing MC4R, MC1R, MC3R, and MC5R (EC50s = 0.27, 5.8, 5.3, and 1,600 nM, respectively, for the human receptors) but not in cells expressing MC2R (EC50 = >10 µM). Setmelanotide (6.4...
Schlagworte: | BIM-22493, N-acetyl-RCAHFRWC-NH2, RM-493, cyclic (2->8)-disulfide... |
Anwendung: | MC4R peptide agonist |
MW: | 1117.3 D |
ab 76,00 €
Artikelnummer: ARG56525.250
Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). [The UniProt Consortium]
Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4 |
Anwendung: | IHC (paraffin), WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
656,00 €
Artikelnummer: G-HUFI01099.96
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
641,00 €
Artikelnummer: 600-401-CR7
Anti-MC4R Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with MC4R from other sources has not been determined. Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a...
Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4 |
Anwendung: | ELISA, IHC, IFM, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
684,00 €
Artikelnummer: Cay24152-1
SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24...
Schlagworte: | N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide,... |
Anwendung: | MC1R agonist, MC4R antagonist |
CAS | 168482-23-3 |
MW: | 1074.2 D |
ab 104,00 €
Artikelnummer: E-AB-15766.120
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity Protein...
Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4, MC4R Polyclonal Antibody |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 71,00 €
Artikelnummer: Cay22473-1
ML-00253764 is a melanocortin receptor 4 (MC4R) antagonist (Ki = 0.16 µM). It is selective for MC4R over MC3R and MC5R (IC50s = 0.32, 0.81, and 2.12 µM, respectively). ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-alpha-melanocyte stimulating hormone ([NDP]-alpha-MSH, Cay-24475) by 20% in...
Schlagworte: | 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole, monohydrochloride |
Anwendung: | Melanocortin MC4 receptor antagonist |
CAS | 1706524-94-8 |
MW: | 413.7 D |
ab 40,00 €
Artikelnummer: Cay27150-5
ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response. An acetylated form of ACTH (1-13), alpha-melanocyte stimulating hormone (alpha-MSH), is formed in the intermediate lobe of the pituitary gland...
Schlagworte: | SYSMEHFRWGKPV-OH, alpha1-13-corticotropin, trifluoroacetate salt |
Anwendung: | Peptide fragment, MC3R / MC4R agonist |
MW: | 1623.8 D |
ab 98,00 €
Artikelnummer: Cay27316-5
Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors). It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory...
Schlagworte: | MT II, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2->7)-lactam,... |
Anwendung: | Melanocortin receptor (MC1R, MC3R, MC4R, MC5R) agonist |
MW: | 1024.2 D |
ab 205,00 €
Artikelnummer: NSJ-RQ6059
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Melanocortin receptor 4 is a protein that in humans is encoded by the MC4R gene. This gene is mapped to 18q21.32. The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with...
Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4, MC4R Antibody / MC4-R / Melanocortin Receptor 4 |
Anwendung: | WB, IHC (paraffin), IF, FC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
755,00 €