Zu "K04202" wurden 57 Artikel gefunden!
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NEU
MC4R Reporter Assay System (human)
Artikelnummer: IB-IB41401
Protein Function: Hormone receptor that acts as a key component of the leptin-melanocortin pathway at the intersection of homeostatic maintenance of energetic state (PubMed:32327598, PubMed:33858992). Plays a role in regulating food intake: activation by a stimulating hormone such as anorexigenic alpha-melanocyte...
| Schlagworte: | MC4R, Melanocortin receptor 4 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
MC4R Cre-CREB Luciferase Reporter HEK293 Cell Line
Artikelnummer: BPS-83951
The MC4R CRE/CREB Luciferase Reporter HEK293 Cell Line expresses full-length human MC4R (melanocortin 4 receptor) (NM_005912.3) under the control of a CMV promoter, for high constitutive expression, and an inducible firefly luciferase reporter under the control of multimerized cAMP response element (CRE), designed...
| Schlagworte: | MC4R, Melanocortin receptor 4 |
| Anwendung: | MC4R specific agonist screening |
| Wirt: | Human cells |
| Spezies-Reaktivität: | human |
13.163,00 €
PT-141 (acetate)
Artikelnummer: Cay35175-10
PT-141 is a cyclic peptide agonist of melanocortin receptor 4 (MC4R) and an analog of alpha-melanocyte stimulating hormone (alpha-MSH, Cay-29923). It binds to MC3R and MC4R and increases intracellular cAMP levels in HEK293 cells expressing MC4R. It increases dopamine release in the medial preoptic area (mPOA) of the...
| Schlagworte: | Bremelanotide Acetate, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine... |
| Anwendung: | MC4R cyclic peptide agonist |
| CAS | 1607799-13-2 |
| MW: | 1085.2 D |
ab 89,00 €
Setmelanotide (trifluoroacetate salt)
Artikelnummer: Cay35564-10
Setmelanotide is a cyclic peptide agonist of melanocortin receptor 4 (MC4R). It increases cAMP production in CHO-K1 cells expressing MC4R, MC1R, MC3R, and MC5R (EC50s = 0.27, 5.8, 5.3, and 1,600 nM, respectively, for the human receptors) but not in cells expressing MC2R (EC50 = >10 µM). Setmelanotide (6.4...
| Schlagworte: | BIM-22493, N-acetyl-RCAHFRWC-NH2, RM-493, cyclic (2->8)-disulfide... |
| Anwendung: | MC4R peptide agonist |
| MW: | 1117.3 D |
ab 87,00 €
Anti-Melanocortin-4 Receptor
Artikelnummer: Cay10006355-1
Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'. These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors,...
| Schlagworte: | Anti-Mc4r, Anti-MC4-R, Anti-MC4-R, Anti-Melanocortin receptor 4, Anti-Melanocortin receptor 4 |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
483,00 €
SHU9119 (trifluoroacetate salt)
Artikelnummer: Cay24152-1
SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24...
| Schlagworte: | N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide,... |
| Anwendung: | MC1R agonist, MC4R antagonist |
| CAS | 168482-23-3 |
| MW: | 1074.2 D |
ab 119,00 €
Anti-Melanocortin-4 Receptor
Artikelnummer: ARG56525.250
Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). [The UniProt Consortium]
| Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4 |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
Human MC4R / Melanocortin receptor 4 ELISA Kit
Artikelnummer: G-HUFI01099.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-MC4R
Artikelnummer: 600-401-CR7
Anti-MC4R Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with MC4R from other sources has not been determined. Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a...
| Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4 |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
Anti-MC4R
Artikelnummer: E-AB-15766.120
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity Protein...
| Schlagworte: | Anti-MC4R, Anti-MC4-R, Anti-Melanocortin receptor 4, MC4R Polyclonal Antibody |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
ML-00253764 (hydrochloride)
Artikelnummer: Cay22473-1
ML-00253764 is a melanocortin receptor 4 (MC4R) antagonist (Ki = 0.16 µM). It is selective for MC4R over MC3R and MC5R (IC50s = 0.32, 0.81, and 2.12 µM, respectively). ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-alpha-melanocyte stimulating hormone ([NDP]-alpha-MSH, Cay-24475) by 20% in...
| Schlagworte: | 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole, monohydrochloride |
| Anwendung: | Melanocortin MC4 receptor antagonist |
| CAS | 1706524-94-8 |
| MW: | 413.7 D |
ab 47,00 €
ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine)...
Artikelnummer: Cay27150-5
ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response. An acetylated form of ACTH (1-13), alpha-melanocyte stimulating hormone (alpha-MSH), is formed in the intermediate lobe of the pituitary gland...
| Schlagworte: | SYSMEHFRWGKPV-OH, alpha1-13-corticotropin, trifluoroacetate salt |
| Anwendung: | Peptide fragment, MC3R / MC4R agonist |
| MW: | 1623.8 D |
ab 114,00 €