Zu "K04199" wurden 39 Artikel gefunden!
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ATC 0175
Artikelnummer: Cay42376-10
An MC1R antagonist (IC50 = 7.23 nM), selective for MC1R over MC2R (IC50 = >10,000 nM) but does antagonize 5-HT2B and 5-HT1A receptors (IC50s = 9.66 and 16.9 nM, respectively), inhibits MCH-induced [35S]GTPgammaS binding and calcium influx in HEK293 cells expressing human MC1R at 3 nM, reduces stress-induced...
| Schlagworte: | N-[cis-4-[[4-(dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluoro-benzamide, monohydrochloride |
| Anwendung: | MC1R antagonist |
| CAS | 510733-97-8 |
| MW: | 461.94 D |
ab 102,00 €
Anti-MC1R
Artikelnummer: E-AB-15765.60
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are...
| Schlagworte: | Anti-MSHR, Anti-MC1R, Anti-MSH-R, Anti-MC1-R, Anti-Melanocortin receptor 1, Anti-Melanocyte-stimulating hormone receptor,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
![[Nle4,D-Phe7]-alpha-MSH (acetate)](https://www.biomol.com/media/image/c0/76/db/Cay41548-1_200x200.png "[Nle4,D-Phe7]-alpha-MSH (acetate)")
[Nle4,D-Phe7]-alpha-MSH (acetate)
Artikelnummer: Cay41548-1
[Nle4,D-Phe7]-alpha-Melanocyte-stimulating hormone ([Nle4,D-Phe7]-alpha-MSH) is a peptide agonist of melanocortin receptor 1 (MC1R). It induces cAMP accumulation in mouse L-cells expressing human MC1R (EC50 = 0.5 nM). It also induces tyrosinase activity in mouse melanoma cells. In vivo, [Nle4,D-Phe7]-alpha-MSH (1.8...
| Schlagworte: | [Nle4,D-Phe7]-alpha-Melanocyte-stimulating Hormone, Afamelanotide, Melanotan I, NDP-MSH, NDP-alpha-MSH,... |
| Anwendung: | MC1R peptide agonist |
| CAS | 1566590-77-9 |
| MW: | 1646.9 D |
ab 142,00 €
Anti-MC1R
Artikelnummer: ARG57965.100
Protein function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. [The UniProt Consortium]
| Schlagworte: | Anti-MSHR, Anti-MC1R, Anti-MSH-R, Anti-MC1-R, Anti-Melanocortin receptor 1, Anti-Melanocyte-stimulating hormone receptor |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
Anti-MC1R
Artikelnummer: E-AB-12554.120
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are...
| Schlagworte: | Anti-MSHR, Anti-MC1R, Anti-MSH-R, Anti-MC1-R, Anti-Melanocortin receptor 1, Anti-Melanocyte-stimulating hormone receptor,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
SHU9119 (trifluoroacetate salt)
Artikelnummer: Cay24152-500
SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24...
| Schlagworte: | N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide,... |
| Anwendung: | MC1R agonist, MC4R antagonist |
| CAS | 168482-23-3 |
| MW: | 1074.2 D |
ab 115,00 €
ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine)...
Artikelnummer: Cay27429-1
ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response. It binds to melanocortin receptors (MCRs, Kis = 0.23, 14, 419, and 4,240 nM for MC1R, MC3R, MC4R, and MC5R, respectively). It is an agonist at...
| Schlagworte: | Adrenocorticotropic Hormone (1-17), SYSMEHFRWGKPVGKKR-OH, alpha1-17-corticotropin, trifluoroacetate salt |
| Anwendung: | Peptide fragment, MC1R agonist |
| MW: | 2093.4 D |
ab 112,00 €
Nonapeptide-1 (acetate)
Artikelnummer: Cay27757-100
Nonapeptide-1 is an antagonist of melanocortin receptor 1 (MC1R, Ki = 40 nM in COS-1 cells expressing human receptors). It is selective for MC1R over MC3R, MC4R, and MC5R (Kis = 470, 1,340, and 2,400 nM, respectively). Nonapeptide-1 inhibits cAMP accumulation and melanosome dispersion induced by...
| Schlagworte: | 153N-6, Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, MPFRWFKPV-NH2,... |
| Anwendung: | MC1R antagonist |
| MW: | 1206.5 D |
ab 200,00 €
Melanotan II (acetate)
Artikelnummer: Cay27316-1
Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors). It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory...
| Schlagworte: | MT II, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2->7)-lactam,... |
| Anwendung: | Melanocortin receptor (MC1R, MC3R, MC4R, MC5R) agonist |
| MW: | 1024.2 D |
ab 228,00 €
AP1189 (acetate)
Artikelnummer: Cay37400-10
AP1189 is a biased agonist of melanocortin receptor 1 (MC1R) and MC3R. It induces ERK1 and ERK2 phosphorylation but not canonical cAMP production in HEK293 cells expressing human MC1R or MC3R when used at concentrations ranging from 10 pM to 1 mM. AP1189 (0.1-10 nM) reduces zymosan-induced IL-1beta, IL-6, and...
| Schlagworte: | 2-[3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-hydrazinecarboximidamide, acetate |
| Anwendung: | Biased MC1R / MC3R agonist |
| CAS | 959850-74-9 |
| MW: | 358.4 D |
ab 60,00 €
Melanocyte-stimulating hormone receptor (MC1R)-VLPs,...
Artikelnummer: CSB-MP086369HU.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 1-317aa. Protein Length: Full Length. Tag Info: C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions). Target Protein Sequence: MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL VSLVENALVV ATIAKNRNLH...
| Schlagworte: | MSHR, MC1R, MC1-R, MSH-R, Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Recombinant Human... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Mammalian cells |
| Ursprungsart: | human |
| MW: | 36.1 kD |
ab 579,00 €
Anti-MC1R
Artikelnummer: CSB-PA010093.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-MC1R, Anti-MSHR, Anti-MC1-R, Anti-MSH-R, Anti-Melanocortin receptor 1, Anti-Melanocyte-stimulating hormone receptor,... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €