Zu "K04174" wurden 46 Artikel gefunden!
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Azelaprag
Artikelnummer: Cay44644-1
An APJ agonist, inhibits forskolin-induced cAMP accumulation in CHO cells expressing human APJ (EC50 = 0.23 nM), increases stroke volume and heart rate and decreases systemic vascular resistance, indicating increased cardiac reserve, in ZSF1 obese rats in a model of diastolic dysfunction at 1 mg/kg, i.v.. SMILES:...
| Schlagworte: | AMG 986, BGE-105,... |
| Anwendung: | APJ (apelin receptor) agonist |
| CAS | 2049980-18-7 |
| MW: | 523.61 D |
ab 188,00 €
(Glp1)-Apelin-13 (trifluoroacetate salt)
Artikelnummer: Cay15590-1
The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Cay-13524), apelin-17, and apelin-13 (Cay-13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50...
| Schlagworte: | (pGlu1)Apelin-13, (Pyr1)Apelin-13, Pyr-Apelin-13,... |
| Anwendung: | APLNR / APJ receptor ligand |
| MW: | 1533.8 D |
234,00 €
Apelin-13 (trifluoroacetate salt)
Artikelnummer: Cay13523-25
The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the...
| Schlagworte: | L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenyl... |
| Anwendung: | APJ receptor ligand |
| MW: | 1550.8 D |
ab 85,00 €
MM-54 (trifluoroacetate salt)
Artikelnummer: Cay42401-1
MM-54 is a peptide antagonist of the apelin receptor (APJ, Ki = 82 nM). It inhibits apelin-13-induced increases in number of stem cells and tumorspheres and the percentage of cells with aldehyde dehydrogenase (ALDH) activity, a marker of stem cells, in patient-derived glioblastoma spheroids when used at a...
| Schlagworte: | L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-lysyl-L-histidyl-L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-... |
| Anwendung: | APJ (APLNR, apelin receptor) peptide antagonist |
| MW: | 1737.16 D |
ab 118,00 €
ML-233
Artikelnummer: Cay15187-1
The apelin receptor (APJ) signaling pathway mediates cardiovascular homeostasis and is involved in the pathogenesis of cardiovascular diseases. ML-233 is a novel APJ agonist (EC50 = 3.7 µM) that is >21-fold selective over the closely related angiotensin 1 receptor (EC50 = >79 µM).Formal Name:...
| Schlagworte: | CID-46905036, (E)-4-methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one |
| Anwendung: | APLNR agonist |
| MW: | 359.4 D |
ab 68,00 €
ML-221
Artikelnummer: Cay27313-5
ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC50 = 4.8 µM). It is selective for APJ over the angiotensin II type 1 (AT1) receptor (IC50 = >78 µM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and beta-arrestin recruitment assays (IC50s = 0.7 and 1.75 µM, respectively). It...
| Schlagworte: | 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one |
| Anwendung: | Apelin receptor (APJ) antagonist |
| CAS | 877636-42-5 |
| MW: | 385.4 D |
ab 97,00 €
Anti-APLNR
Artikelnummer: E-AB-13919.120
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive...
| Schlagworte: | Anti-APLNR, Anti-AGTRL1, Anti-Apelin receptor, Anti-Angiotensin receptor-like 1, Anti-G-protein coupled receptor APJ,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-APLNR
Artikelnummer: E-AB-10156.120
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive...
| Schlagworte: | Anti-APLNR, Anti-AGTRL1, Anti-Apelin receptor, Anti-Angiotensin receptor-like 1, Anti-G-protein coupled receptor APJ,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-APLNR / APJ
Artikelnummer: ARG40385.100
Protein function: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart...
| Schlagworte: | Anti-APLNR, Anti-AGTRL1, Anti-Apelin receptor, Anti-Angiotensin receptor-like 1, Anti-G-protein coupled receptor APJ,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
658,00 €
Human APLNR (Apelin Receptor) ELISA Kit
Artikelnummer: ELK-ELK8782.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human APLNR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human APLNR. Next,...
| Schlagworte: | APLNR, AGTRL1, Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Apelin receptor (Aplnr), partial, mouse, recombinant
Artikelnummer: CSB-EP001910MO1.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 307-377aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: YAFFDPRFRQ ACTSMLCCDQ SGCKGTPHSS SAEKSASYSS GHSQGPGPNM GKGGEQMHEK SIPYSQETLV D. Purity: Greater than 85% as determined by...
| Schlagworte: | MSR, Aplnr, Agtrl1, Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, Recombinant Mouse Apelin... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | mouse |
| MW: | 15.1 kD |
ab 364,00 €
Human APLNR Protein, hFc Tag
Artikelnummer: DIM-PME101471.10
Recombinant human APLNR Protein with C-terminal human Fc tag. APLNR(Met1-Ser26) hFc(Glu99-Ala330), Protein function: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753,...
| Schlagworte: | APJ, APJR, HG11, AGTRL1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 29.2 kD |
ab 132,00 €