Zu "K04162" wurden 18 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
ST1936
Artikelnummer: Cay39811-1
ST1936 is an agonist of the serotonin (5-HT) receptor subtype 5-HT6. It selectively binds to 5-HT6 (Ki = 31 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, and the serotonin transporter (SERT, Kis = >1,000 nM for all) but also binds to the 5-HT7 receptor (Ki = 168 nM). ST1936 induces...
| Schlagworte: | 5-chloro-N,N,2-trimethyl-1H-indole-3-ethanamine |
| Anwendung: | 5-HT6 receptor agonist |
| CAS | 1210-81-7 |
| MW: | 236.7 D |
ab 53,00 €
SB-258585 (hydrochloride)
Artikelnummer: Cay17416-10
SB-258585 is a potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53). It displays over 100-fold selectivity for 5-HT6 over other 5-HT, dopamine, and alpha-adrenergic receptors. Radiolabeled forms of SB-258585 have been used to evaluate other potential ligands of the 5-HT6 receptor. SB-258585 has...
| Schlagworte: | 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-benzenesulfonamide, monohydrochloride |
| Anwendung: | 5-HT6 receptor antagonist |
| CAS | 1216468-02-8 |
| MW: | 523.8 D |
ab 43,00 €
Anti-5-HT6
Artikelnummer: A304-401A
Protein function: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic...
| Schlagworte: | Anti-HTR6, Anti-5-HT6, Anti-5-HT-6, Anti-Serotonin receptor 6, Anti-5-hydroxytryptamine receptor 6 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
SB-742457
Artikelnummer: Cay22200-1
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 µM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an...
| Schlagworte: | GSK742457, 3-(phenylsulfonyl)-8-(1-piperazinyl)-quinoline |
| Anwendung: | 5-HT6 receptor antagonist |
| CAS | 607742-69-8 |
| MW: | 353.4 D |
ab 50,00 €
MS 245 (oxalate)
Artikelnummer: Cay11936-1
MS 245 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 2.3 nM for the human recombinant receptor). It is selective for 5-HT6 over 5-HT2A and 5-HT2C receptors (Kis = 130 and 23 nM, respectively), as well as 5-HT1A, 5-HT1B, 5-HT1E, 5-HT3, and 5-HT7 receptors (Kis = 720, 9,200, 4,220, 2,390, and...
| Schlagworte: | 5-methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine, monoethanedioate |
| Anwendung: | 5-HT6 antagonist |
| CAS | 275363-58-1 |
| MW: | 448.5 D |
ab 50,00 €
WAY-208466 (hydrochloride)
Artikelnummer: Cay11938-1
WAY-208466 is a selective 5-HT6 receptor agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). It has been shown to increase cortical GABA levels in rat frontal cortex, producing anxiolytic-like effects in vivo. Formal Name: 3-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine,...
| Schlagworte: | 3-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine, dihydrochloride |
| Anwendung: | 5-HT6 agonist |
| CAS | 1207064-61-6 |
| MW: | 420.3 D |
ab 43,00 €
SB-271046 (hydrochloride)
Artikelnummer: Cay18513-10
SB-271046 is an orally-available antagonist of the serotonin (5-hydroxytryptamine, or 5-HT, Cay-14332) receptor 5-HT6 (pKi = 9.02-8.92). It is at least 100-fold selective for 5-HT6 over other 5-HT receptors, as well as 55 other receptors, enzymes, and ion channels. While it does not alter basal levels of 5-HT,...
| Schlagworte: | 5-chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide, monohydrochloride |
| Anwendung: | 5-HT6 antagonist |
| CAS | 209481-24-3 |
| MW: | 488.4 D |
ab 109,00 €
AVN-492
Artikelnummer: Cay28079-1
AVN-492 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.09 nM). It selectively inhibits the 5-HT6 receptor over the 5-HT2B receptor (IC50s = 0.19 and 268 nM, respectively, in a radioligand binding assay). AVN-492 inhibits increases in cAMP levels induced by 5-HT in HEK293 cells expressing the...
| Schlagworte: | N2,N6,N6,5,7-pentamethyl-3-(phenylsulfonyl)-pyrazolo[1,5-a]pyrimidine-2,6-diamine |
| Anwendung: | 5-HT6R antagonist |
| CAS | 1220646-23-0 |
| MW: | 359.4 D |
ab 50,00 €
Lu AE58054
Artikelnummer: Cay27335-100
LU AE58054 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.83 nM). It is selective for 5-HT6 over other 5-HT receptor subtypes (Kis = 250 to >10,000 nM) and 70 other targets but does bind to alpha1A- and alpha1B-adrenergic receptors (alpha1B-ARs, Kis = 21 and 22 nM, respectively). LU AE58054...
| Schlagworte: | 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-indole-3-ethanamine |
| Anwendung: | Serotonin receptor 5-HT6 antagonist |
| CAS | 467459-31-0 |
| MW: | 398.4 D |
ab 205,00 €
SB-399885 (hydrochloride)
Artikelnummer: Cay32817-10
SB-399885 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.72 nM). It is greater than 200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM. SB-399885 inhibits 5-HT-induced cAMP accumulation in HeLa cells expressing recombinant human 5-HT6...
| Schlagworte: | N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide, monohydrochloride |
| Anwendung: | 5-HT6 receptor antagonist |
| CAS | 402713-81-9 |
| MW: | 482.8 D |
ab 175,00 €
Ro 04-6790 (hydrochloride hydrate)
Artikelnummer: Cay34476-10
Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 44.7 nM). It is selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75). In vivo, Ro 04-6790 (10 and 30 mg/kg)...
| Schlagworte: | 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide, dihydrochloride hydrate |
| Anwendung: | 5-HT6 receptor antagonist |
| MW: | 381.3 D |
ab 147,00 €
Human 5HTR6 (5-Hydroxytryptamine Receptor 6) ELISA Kit
Artikelnummer: ELK-ELK8828.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human 5HTR6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human 5HTR6. Next,...
| Schlagworte: | HTR6, 5-HT6, 5-HT-6, Serotonin receptor 6, 5-hydroxytryptamine receptor 6 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €