Zu "K04146" wurden 65 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Pimozide
Artikelnummer: Cay16222-50
Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively). It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42...
| Schlagworte: | NSC 170984, R 6238, 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
| Anwendung: | Dopamine D2/D3-receptor antagonist |
| CAS | 2062-78-4 |
| MW: | 461.6 D |
ab 49,00 €
Fluspirilene
Artikelnummer: Cay19530-5
Fluspirilene is a dopamine D2 and D3 receptor antagonist (Kis = 1.5 and 1.1 nM, respectively). It is selective for dopamine D2 and D3 receptors over dopamine D1, alpha1- and alpha2-adrenergic, H1 histamine, and sigma-1 (sigma1) receptors (Kis = 450, 102, >5,000, 540, and 150 nM, respectively), muscarinic...
| Schlagworte: | McN-JR 6218, R 6218, Redeptin, 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
| Anwendung: | Calcium channel blocker, dopamine receptor antagonist |
| CAS | 1841-19-6 |
| MW: | 475.6 D |
ab 108,00 €
Amisulpride
Artikelnummer: Cay14619-25
Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion...
| Schlagworte: | DAN 2163, 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-benzamide |
| Anwendung: | D2 and D3 dopamine receptor antagonist, 5-HT2B and 5-HT7 serotonin receptor antagonist |
| CAS | 71675-85-9 |
| MW: | 369.5 D |
ab 67,00 €
Pramipexole dihydrochloride
Artikelnummer: LKT-P6901.25
Is a medication for treating Parkinsons disease and restless leg syndrome. A non-ergoline dopamine agonist.
| Schlagworte: | Pramipexole hydrochloride hydrate |
| Anwendung: | Dopamine D2/3/4-receptor agonist |
| CAS | 104632-25-9 |
| MW: | 211,33 D |
ab 141,00 €
SB 277011A (hydrochloride)
Artikelnummer: Cay11982-25
SB 277011A is an antagonist of the dopamine D3 receptor (pKi = 8.0) that is at least 100-fold selective for D3 over other monoamine receptors (pKis = 6.0, 5.0, and 2, 5-HT1D and 5-HT1B respectively). It has high oral bioavailability and enters the central nervous system of the rat. SB 277011A has been shown to have...
| Schlagworte: | N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide, dihydrochloride |
| Anwendung: | DRD3 antagonist |
| CAS | 1226917-67-4 |
| MW: | 511.5 D |
ab 67,00 €
PG-01037 (hydrochloride)
Artikelnummer: Cay22079-10
PG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively). It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces...
| Schlagworte: | N-[(2E)-4-[4-(2,3-dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridinyl)-benzamide, dihydrochloride |
| Anwendung: | DRD3 antagonist |
| CAS | 675599-62-9 |
| MW: | 554.3 D |
ab 49,00 €
R,S-(±)-Sulpiride
Artikelnummer: LKT-S8344.5
Sulpiride is an antipsychotic that functions as an antagonist at D2/3 receptors and also upregulates and activates the GHB receptor. In vivo, sulpiride ameliorates increased impulsivity and attentional impairment in PFC-lesioned models of schizophrenia. Additionally, because dopamine inhibits prolactin release,...
| Anwendung: | Dopamine D2-receptor antagonist, Dopamine D3-receptor antagonist |
| CAS | 15676-16-1 |
| MW: | 341.42 D |
ab 79,00 €
Anti-Dopamine Receptor D3
Artikelnummer: NSJ-R30661
0.5mg/ml if reconstituted with 0.2ml sterile DI water. DRD3 is a dopamine receptor that differs in its pharmacology and signaling system from the D1 and D2 receptors and represents both an autoreceptor and a postsynaptic receptor. DRD3 is localized to limbic areas of the brain, which are associated with cognitive,...
| Schlagworte: | Anti-DRD3, Anti-Dopamine D3 receptor, Anti-D(3) dopamine receptor, Dopamine Receptor D3 Antibody |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
NGB 2904 (hydrochloride)
Artikelnummer: Cay21457-1
NGB 2904 is an antagonist that is selective for the dopamine D3 receptor (Ki = 1.4 nM). It potently inhibits quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). NGB 2904 attenuates cocaine- and stress-induced reinstatement of drug-seeking behavior in rats. It also increases spontaneous and amphetamine-stimulated...
| Schlagworte: | N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide, monohydrochloride |
| Anwendung: | Dopamine D3 receptor antagonist |
| CAS | 189061-11-8 |
| MW: | 530.9 D |
ab 58,00 €
Amisulpride
Artikelnummer: LKT-A5234.25
Used in treatment of schizophrenia. Highly selective D2/D3 dopamine receptor antagonist.
| Anwendung: | D2/D3 dopamine receptor antagonist |
| CAS | 71675-85-9 |
| MW: | 369,48 D |
ab 128,00 €
S-(-)-Sulpiride
Artikelnummer: LKT-S8345.25
Sulpiride is an antipsychotic that functions as an antagonist at D2/3 receptors and also upregulates and activates the GHB receptor. In vivo, sulpiride ameliorates increased impulsivity and attentional impairment in PFC-lesioned models of schizophrenia. Additionally, because dopamine inhibits prolactin release,...
| Anwendung: | Dopamine D2-receptor antagonist, Dopamine D3-receptor antagonist |
| CAS | 23672-07-3 |
| MW: | 341.43 D |
ab 79,00 €
(S)-Pramipexole (hydrochloride)
Artikelnummer: Cay11981-10
(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPgammaS binding assay). It is also a partial agonist of alpha2A-adrenergic receptors (alpha2A-ARs, EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors...
| Schlagworte: | (-)-Pramipexole, (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride |
| Anwendung: | Galphai agonist |
| CAS | 104632-25-9 |
| MW: | 284.2 D |
ab 49,00 €