Zu "K04143" wurden 70 Artikel gefunden!
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Mirabegron
Artikelnummer: Cay17319-10
Mirabegron is an agonist of the beta3-adrenergic receptor (beta3-AR). It induces cAMP accumulation in CHO cells expressing the beta3-AR but not the beta1- or beta2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Cay-14486) of isolated rat and human...
| Schlagworte: | YM-178, 2-amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide |
| Anwendung: | beta3-adrenergic receptor agonist |
| CAS | 223673-61-8 |
| MW: | 396.5 D |
ab 56,00 €
L-755,507
Artikelnummer: Cay18629-1
L-755,507 is a partial agonist of beta3-adrenergic receptors (EC50 = 0.43 nM). It displays more than 440-fold selectivity for beta3- over beta1- and beta2-adrenoceptors (EC50s = 580 and >10,000 nM, respectively). At 5 µM, this compound has been used to enhance CRISPR-mediated homology-directed repair efficiency by...
| Schlagworte: | 4-[[(hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide |
| Anwendung: | Partial beta-3 adrenergic receptor agonist |
| CAS | 159182-43-1 |
| MW: | 584.7 D |
ab 49,00 €
Isoproterenol hydrochloride
Artikelnummer: LKT-I7259.5
A beta-adrenergic agonist.
| Anwendung: | beta-adrenergic agonist |
| CAS | 51-30-9 |
| MW: | 247,72 D |
ab 121,00 €
CL 316,243 (sodium salt)
Artikelnummer: Cay17499-10
CL 316,243 is a beta3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over beta1 and beta2. It causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity.Formal Name:...
| Schlagworte: | 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid, disodium salt |
| Anwendung: | beta3-adrenoceptor agonist |
| CAS | 138908-40-4 |
| MW: | 465.8 D |
ab 49,00 €
SR 59230A (hydrochloride)
Artikelnummer: Cay21407-1
SR 59230A (hydrochloride) is a beta3-adrenergic receptor (beta3-AR) antagonist (pA2s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for beta3-AR in cells transfected with the human beta-AR subtypes (Kis = 16.4, 61.9, and 122 nM for beta1-,...
| Schlagworte: | (2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-2-propanol, monohydrochloride |
| Anwendung: | ADRB3 antagonist |
| CAS | 1135278-41-9 |
| MW: | 361.9 D |
ab 56,00 €
SR 58611A (hydrochloride)
Artikelnummer: Cay11954-10
SR 58611A is a selective beta3-adrenergic receptor agonist (beta3-AR, EC50 = 3.5 nM in rat colon). Its activity cannot be blocked by the beta1- and beta2-AR antagonists CGP 20712A and ICI 118551 (Cay-15591), respectively. SR 58611A is minimally active against beta1-ARs in rat uterus (EC50 = 499 nM) and inactive...
| Schlagworte: | Amibegron, [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-acetic acid,... |
| Anwendung: | Selective beta3-adrenergic receptor agonist |
| CAS | 121524-09-2 |
| MW: | 440.4 D |
ab 89,00 €
Alprenolol
Artikelnummer: Cay25338-50
Alprenolol is a non-selective beta-adrenergic receptor (beta-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. It binds to beta1-, beta2-, and beta3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and...
| Schlagworte: | (±)-Alprenolol, (RS)-Alprenolol, dl-Alprenolol, 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-2-propanol |
| Anwendung: | beta1/2/3-Adrenergic receptor antagonist |
| CAS | 13655-52-2 |
| MW: | 249.4 D |
ab 85,00 €
Levobunolol (hydrochloride)
Artikelnummer: Cay21005-50
Levobunolol (hydrochloride) is a beta-adrenergic antagonist that acts as a vasodilator and increases ocular circulation when applied in solution to the eye. Topical formulations containing levobunolol are used to manage glaucoma.Formal Name:...
| Schlagworte: | -(-)Bunolol, AG-901, W-7000A, 5-[(2S)-3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone,... |
| Anwendung: | beta-Adrenergic receptor antagonist |
| CAS | 27912-14-7 |
| MW: | 327.9 D |
ab 128,00 €
BRL 37344 (sodium salt)
Artikelnummer: Cay18622-1
BRL 37344 is a selective agonist of beta3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for beta3, beta2, and beta1, respectively. beta3-Adrenoceptors are expressed in adipose tissue as well as endothelial and myocardial tissues. This compound has been used to explore the role of these receptors in...
| Schlagworte: | BRL 37344A, rel-2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-acetic acid, monosodium salt |
| Anwendung: | Selective beta-3 adrenergic receptor agonist |
| CAS | 127299-93-8 |
| MW: | 385.8 D |
ab 73,00 €
L-748,337
Artikelnummer: Cay19643-1
L-748,337 is a beta3-adrenergic receptor antagonist that displays selectivity over beta1 and beta2 receptors (Kis = 4, 390, and 204 nM, respectively). It has been shown to couple with Gi to activate MAPK signaling. L-748,337 can inhibit agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as...
| Schlagworte: | N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide |
| Anwendung: | beta3-adrenoceptor antagonist |
| CAS | 244192-94-7 |
| MW: | 497.6 D |
ab 56,00 €
Penbutolol (hemisulfate)
Artikelnummer: Cay29524-50
Penbutolol is an antagonist of beta-adrenergic receptors (beta-ARs, IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM). It inhibits adenylate cyclase activity induced by the beta-AR agonist isoprenaline (isoproterenol, Cay-15592) in guinea pig myocardial membranes with a Ki value of 2.4...
| Schlagworte: | HOE 39-893d, (2S)-1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol, hemisulfate |
| Anwendung: | beta-Adrenergic receptor antagonist, 5-HT1A receptor antagonist |
| CAS | 38363-32-5 |
| MW: | 340.5 D |
ab 57,00 €
Anti-ADRB3, N-terminal
Artikelnummer: ARG64409.100
Protein function: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. [The UniProt Consortium]
| Schlagworte: | Anti-ADRB3, Anti-ADRB3R, Anti-Beta-3 adrenoceptor, Anti-Beta-3 adrenoreceptor, Anti-Beta-3 adrenergic receptor |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €