Zu "K04140" wurden 62 Artikel gefunden!
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CHO-K1/ADRA2C/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00252
The adrenoceptors ADRA2C is expressed in the brain, kidney, aorta, lung, skeletal muscle, heart and spleen. ADRA2C knockout mice exhibited disrupts presynaptic inhibition of noradrenaline release at low stimulation frequencies.
| Schlagworte: | ADRA2C, Alpha-2C adrenoreceptor, Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4 |
11.424,00 €
Idazoxan (hydrochloride)
Artikelnummer: Cay41310-5
Idazoxan is an antagonist of alpha2-adrenergic receptors (alpha2-ARs) and imidazoline I1 and I2 receptors (IC50s = 69, 66, and 61 nM, respectively). It selectively binds to alpha2A- and alpha2C-ARs over alpha2B-ARs (Kds = 67, 69, and 407 nM, respectively), as well as alpha2-ARs over alpha1-ARs (IC50s = 0. and 4,000...
| Schlagworte: | RX 781094, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole, monohydrochloride |
| Anwendung: | Adrenergic receptor alpha antagonist |
| CAS | 79944-56-2 |
| MW: | 240.69 D |
ab 81,00 €
Atipamezole (hydrochloride)
Artikelnummer: Cay9001181-5
Atipamezole is an antagonist of alpha2A-adrenergic receptors (alpha2A-ARs, Ki = 1.86 nM). It is selective for alpha2A-ARs over alpha2B- and alpha1-ARs (Kis = 1,949.83 and 13,300 nM, respectively), as well as over 40 receptors, ion channels, and transporters (IC50s = 540->10,000 nM). Atipamezole (0.04, 0.08, and 1.2...
| Schlagworte: | Antisedan(R), 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor antagonist |
| CAS | 104075-48-1 |
| MW: | 248.8 D |
ab 108,00 €
Dexmedetomidine (hydrochloride)
Artikelnummer: Cay15581-5
Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to alpha2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of alpha1-adrenoceptors (Ki = 1.8 µM). Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic...
| Schlagworte: | Dex, Precedex, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 145108-58-3 |
| MW: | 236.7 D |
ab 73,00 €
Rauwolscine (hydrochloride)
Artikelnummer: Cay15596-50
Rauwolscine is a natural alkaloid that acts as a selective and reversible alpha2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki...
| Schlagworte: | Isoyohimbine, NSC 407307, alpha-Yohimbine, (16beta,17alpha,20alpha)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester,... |
| Anwendung: | Selective, reversible alpha2-adrenergic receptor antagonist |
| CAS | 6211-32-1 |
| MW: | 390.9 D |
ab 56,00 €
Guanabenz (hydrochloride)
Artikelnummer: Cay10851-25
Guanabenz is an alpha2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects. It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).Formal Name: 2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide, monohydrochloride. CAS Number: 23113-43-1....
| Schlagworte: | Wytensin, 2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 23113-43-1 |
| MW: | 267.5 D |
ab 68,00 €
Quercetin 3-O-glucuronide
Artikelnummer: Cay21289-1
Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John's wort) that inhibits the alpha2c adrenergic receptor (Ki = 4,060 nM in halpha2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the...
| Schlagworte: | Miquelianin, Quercetin 3-O-beta-D-glucuronide,... |
| Anwendung: | alpha-2C adrenergic receptor inhibitor |
| CAS | 22688-79-5 |
| MW: | 478.4 D |
ab 73,00 €
Clonidine (hydrochloride)
Artikelnummer: Cay15949-500
Clonidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Kis = 61.66, 69.18, and 134.9 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively). It stimulates [35S]GTPgammaS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for alpha2A-,...
| Schlagworte: | ST 155, N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 4205-91-8 |
| MW: | 266.6 D |
ab 49,00 €
Medetomidine (hydrochloride)
Artikelnummer: Cay16454-50
Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...
| Schlagworte: | Domitor(R), MPV 785, 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 86347-15-1 |
| MW: | 236.7 D |
ab 93,00 €
Yohimbine (hydrochloride)
Artikelnummer: Cay19869-500
Yohimbine is a natural alkaloid that has highest affinity for alpha2-adrenergic receptors (pKis = 8.2, 8.7, and 9.6 for human alpha2A, alpha2B, and alpha2C, respectively), with antagonist activity at these receptors. It less potently antagonizes serotonin 5-HT1 receptors (pKis = 7.3, 6.8, and 7.6 for human HT1A,...
| Schlagworte: | NIH 9689, NSC 19509, Yohimbe, 17alpha-hydroxy-yohimban-16alpha-carboxylic acid, methyl ester, monohydrochloride |
| Anwendung: | Alpha-2A/B/C adrenergic receptor antagonist |
| CAS | 65-19-0 |
| MW: | 390.9 D |
ab 49,00 €
Brimonidine-d4
Artikelnummer: Cay25465-5
Brimonidine-d4 is intended for use as an internal standard for the quantification of brimonidine (Cay-15426) by GC- or LC-MS. Brimonidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Kis = 2.7, 52, and 44 nM for alpha2A, alpha2B, and alpha2C-ARs, respectively, in CHO cells). It is selective for...
| Schlagworte: | 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl-4,4,5,5-d4)quinoxalin-6-amine |
| Anwendung: | alpha2-Adrenergic receptor agonist, GC-MS, LC-MS, internal standard |
| CAS | 1184971-51-4 |
| MW: | 296.2 D |
ab 139,00 €
Miquelianin
Artikelnummer: TGM-TQ0188-10mg
Description: Miquelianin (Quercetin 3-glucuronide) is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities. Target: Endogenous Metabolite, stilbene oxidase. Smiles: O[C@H]1[C@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O....
| Schlagworte: | Quercetin 3-O-glucuronide, Quercetin 3-glucuronide |
| Anwendung: | alpha-2C adrenergic receptor inhibitor |
| CAS | 22688-79-5 |
| MW: | 478.36 D |
ab 77,00 €