Zu "K04136" wurden 58 Artikel gefunden!
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CHO-K1/ADRA1B Stable Cell Line
Artikelnummer: GSC-M00260
Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 1B (ADRA1B) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.
| Schlagworte: | ADRA1B, Alpha-1B adrenoreceptor, Alpha-1B adrenergic receptor |
11.424,00 €
2-PMDQ
Artikelnummer: Cay43206-1
2-PMDQ is an antagonist of alpha1-adrenergic receptors (alpha1-ARs, Ki = 1. nM). It is selective for alpha1-ARs over alpha2-ARs (Ki = 962 nM). 2-PMDQ has antihypertensive activity in anesthetized rats (ED50 = 0. mg/kg).. Solulibility: DMSO: Slightly soluble: 0.1-1 mg/ml: .
| Schlagworte: | AT-112, 2,6-dihydro-2-[(4-phenyl-1-piperazinyl)methyl]-imidazo[1,2-c]quinazolin-5(3H)-one |
| Anwendung: | alpha1-adrenergic receptor antagonist |
| CAS | 139047-55-5 |
| MW: | 361.45 D |
ab 53,00 €
(-)-Norepinephrine (bitartrate hydrate)
Artikelnummer: Cay16673-100
(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...
| Schlagworte: | Arterenol, Levarterenol, L-Noradrenaline, NE, 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-benzenediol... |
| Anwendung: | Adrenergic receptor agonist, dopamine beta-hydroxylase metabolite |
| CAS | 108341-18-0 |
| MW: | 337.3 D |
ab 50,00 €
Urapidil (hydrochloride)
Artikelnummer: Cay29004-250
Urapidil is an antagonist of alpha1-adrenergic receptors (alpha1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to alpha1- over alpha2-ARs (IC50s = 0.74 and 42 µM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 µM,...
| Schlagworte: | 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride |
| Anwendung: | alpha1-Adrenergic receptor antagonist |
| CAS | 64887-14-5 |
| MW: | 423.9 D |
ab 110,00 €
Doxazosin (mesylate)
Artikelnummer: Cay18633-100
Doxazosin is a non-selective antagonist of alpha1-adrenergic receptors (alpha1-ARs, Kis = 3.16, 1, and 3.98 nM for alpha1A-, alpha1B-, and alpha1D-ARs, respectively). It inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively....
| Schlagworte: | UK 33274-27, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone,... |
| Anwendung: | alpha1-adrenergic receptor antagonist |
| CAS | 77883-43-3 |
| MW: | 547.6 D |
ab 67,00 €
Rec 15/2615 (hydrochloride)
Artikelnummer: Cay27677-10
Rec 15/2615 is an antagonist of alpha1B-adrenergic receptors (alpha1B-ARs, Ki = 0.45 nM for the recombinant human receptor). It selectively inhibits alpha1B-ARs over alpha1A-, alpha1D-, and alpha1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated...
| Schlagworte: | SB 216469, 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]-ethanone,... |
| Anwendung: | alpha1B-adrenergic receptor antagonist |
| CAS | 1782573-48-1 |
| MW: | 568.5 D |
ab 67,00 €
Midodrine (hydrochloride)
Artikelnummer: Cay17349-100
Midodrine is a prodrug form of the alpha1-adrenergic receptor (alpha1-AR) agonist desglymidodrine (Cay-35608). It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats. Formulations containing midodrine have...
| Schlagworte: | 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-acetamide, monohydrochloride |
| Anwendung: | alpha1-adrenergic receptor agonist prodrug |
| CAS | 43218-56-0 |
| MW: | 290.7 D |
ab 50,00 €
Anti-ADRA1B
Artikelnummer: NSJ-R36077-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Alpha-1B adrenoceptor Protein function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system....
| Schlagworte: | Anti-ADRA1B, Anti-Alpha-1B adrenoceptor, Anti-Alpha-1B adrenoreceptor, Anti-Alpha-1B adrenergic receptor, ADRA1B Antibody |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat, swine |
836,00 €
Anti-ADRA1B
Artikelnummer: NSJ-R36216-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Alpha-1B-adrenergic receptor Protein function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger...
| Schlagworte: | Anti-ADRA1B, Anti-Alpha-1B adrenoceptor, Anti-Alpha-1B adrenoreceptor, Anti-Alpha-1B adrenergic receptor, ADRA1B Antibody |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Prazosin (hydrochloride)
Artikelnummer: Cay15023-250
Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to alpha1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, over alpha2-ARs (Kis = 340 and 3.7 nM in alpha2A-AR-expressing HT-29 cells and...
| Schlagworte: | CP 12,299-1, NSC 292810, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone, monohydrochloride |
| Anwendung: | Antihypertensive agent, melatonin MT3 receptor antagonist |
| CAS | 19237-84-4 |
| MW: | 419.9 D |
ab 49,00 €
Tamsulosin (hydrochloride)
Artikelnummer: Cay24020-25
Tamsulosin is a potent antagonist of alpha1-adrenergic receptors (alpha1-ARs, Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for alpha1-ARs over alpha2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on...
| Schlagworte: | LY253351, YM-12617-1, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-benzenesulfonamide, monohydrochloride |
| Anwendung: | alpha1-Adrenergic receptor antagonist |
| CAS | 106463-17-6 |
| MW: | 445 D |
ab 72,00 €
Silodosin
Artikelnummer: LKT-S3346.25
A potent and highly selective antagonist of human alpha 1a-adrenoceptor.
| Schlagworte: | KAD 3213, KMD 3213 |
| Anwendung: | Antagonist of human alpha 1a-adrenoceptor |
| CAS | 160970-54-7 |
| MW: | 495,53 D |
ab 140,00 €