Zu "K04097" wurden 49 Artikel gefunden!
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Anti-Prostaglandin D Synthase (hematopoietic-type, human)...
Artikelnummer: Cay10004345-1
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory...
| Schlagworte: | H-PGD Synthase, H-PGDS |
| Anwendung: | IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse |
468,00 €
TFC 007
Artikelnummer: Cay17971-5
TFC 007 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS, IC50 = 0.083 µM). It is selective for H-PGDS over lipocalin PGDS (L-PGDS) and microsomal PGE2 synthase (mPGES) at 100 µM. It is also selective for H-PGDS over COX-1, COX-2, 5-lipoxygenase (5-LO), leukotriene C4 (LTC4) synthase, and...
| Schlagworte: | N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide |
| Anwendung: | H-PGDS inhibitor |
| CAS | 927878-49-7 |
| MW: | 487.6 D |
ab 56,00 €
Anti-Prostaglandin D Synthase
Artikelnummer: ARG56489.250
Protein function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits...
| Schlagworte: | Anti-GSTS, Anti-HPGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-Glutathione S-transferase, Anti-Prostaglandin-H2... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat, baboon |
707,00 €
Anti-Prostaglandin D Synthase (hematopoietic-type, human)
Artikelnummer: Cay10004337-1
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory...
| Schlagworte: | Anti-GSTS, Anti-H-PGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-GST class-sigma, Anti-Glutathione S-transferase,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
468,00 €
Prostaglandin D Synthase (hematopoietic-type, human,...
Artikelnummer: Cay10006593-100
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory...
| Schlagworte: | H-PGDS, Hematopoietic-PGDS, hH-PGDS, PGD Synthase (hematopoietic-type, human recombinant) |
| Anwendung: | Enzyme activity |
| MW: | 23,3 kD |
570,00 €
Anti-Prostaglandin D Synthase (hematopoietic-type)
Artikelnummer: Cay160013-1
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory...
| Schlagworte: | Anti-GSTS, Anti-H-PGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-GST class-sigma, Anti-Glutathione S-transferase,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
468,00 €
Prostaglandin D Synthase (hematopoietic-type) FP-Based...
Artikelnummer: Cay600007-1920
Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. H-PGDS is therefore a key target for development of selective, potent inhibitors for therapeutic use against these diseases. Cayman's H-PGDS...
| Schlagworte: | H-PGDS FP-Based Inhibitor Screening Assay Kit - Green, Prostaglandin D Synthase (hematopoietic-type) Fluorescence... |
| Anwendung: | PGDS inhibitor screening |
ab 616,00 €
Prostaglandin D Synthase (hematopoietic-type) Inhibitor F092
Artikelnummer: Cay28721-1
Prostaglandin D synthase (hematopoietic-type) inhibitor F092 is an inhibitor of hematopoietic-type prostaglandin D synthase (H-PGDS, KD = 0.14 nM).Formal Name: N-[4-(2-oxo-1-pyrrolidinyl)phenyl]-2-(2-pyridinyl)-5-pyrimidinecarboxamide. CAS Number: 2250261-59-5. Molecular Formula: C20H17N5O2. Formula Weight: 359.4....
| Schlagworte: | N-[4-(2-oxo-1-pyrrolidinyl)phenyl]-2-(2-pyridinyl)-5-pyrimidinecarboxamide |
| Anwendung: | Hematopoietic prostaglandin D synthase (H-PGDS) inhibitor |
| CAS | 2250261-59-5 |
| MW: | 359.4 D |
ab 93,00 €
TAS 205
Artikelnummer: Cay33261-1
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS, IC50 = 55.8 nM). It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 µM, as well as over enzyme and receptor panels at 10 µM. TAS 205 inhibits production of prostaglandin D2 (PGD2, Cay-12010) induced by A23187 (Cay-11016) in...
| Schlagworte: | 4-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-1-piperazinecarboxamide,... |
| Anwendung: | H-PGDS inhibitor |
| CAS | 1584160-52-0 |
| MW: | 526.6 D |
ab 128,00 €
Anti-HPGDS
Artikelnummer: ATA-HPA024035.100
Protein function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits...
| Schlagworte: | Anti-GSTS, Anti-H-PGDS, Anti-GST class-sigma, Anti-Glutathione S-transferase, Anti-Prostaglandin-H2 D-isomerase,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
PROTAC(H-PGDS)-7
Artikelnummer: Cay35561-1
PROTAC(H-PGDS)-7 is a proteolysis-targeting chimera (PROTAC) comprised of the hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC-007 (Cay-17971) and the cereblon inhibitor pomalidomide (Cay-19877). It induces degradation of H-PGDS in KU812 cells with a 50% degradation concentration (DC50) value of 17.3...
| Schlagworte: | Proteolysis-targeting Chimera (Prostaglandin D Synthase (hematopoietic-type))-7,... |
| Anwendung: | PROTAC, H-PGDS degradation |
| CAS | 2761281-50-7 |
| MW: | 742.8 D |
ab 293,00 €
TFC-007
Artikelnummer: TGM-T24870-10mg
Description: TFC-007 is a selective and efficient hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, suppressing inflammatory factors. It can be used to synthesize H-PGDS degrader PROTAC (H-PGDS)-1 and study cedar pollen-induced guinea pig allergic rhinitis. Target: PGE Synthase, Ligands for Target Protein...
| Schlagworte: | TFC007 |
| Anwendung: | H-PGDS inhibitor |
| CAS | 927878-49-7 |
| MW: | 487.55 D |
ab 60,00 €