Zu "K04079" wurden 353 Artikel gefunden!
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Geldanamycin, FITC-labeled
Artikelnummer: BPS-50312
2.5 µmol/L. A novel geldanamycin fluorescent probe optimized for use with BPS's HSP90 kits (linked). May also be used for detection of cell surface HSP90. Supplied as: DMSO solution (2.5 µM). Avoid freeze/thaw cycles. Keep DMSO stock solutions out of contact with air. Protect from light.
| Anwendung: | HSP90 detection, kit component |
| CAS | 30562-34-6 |
| MW: | 1260.5 D |
303,00 €
Anti-Recombinant HSP90 beta, clone A257
Artikelnummer: E-AN301558L.100
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
| Schlagworte: | Anti-HSP90AB1, Anti-Heat shock 84 kDa, Anti-Heat shock protein HSP 90-beta, Anti-Heat shock protein family C member 3,... |
| Anwendung: | WB, IHC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Hsp90 alpha ELISA kit
Artikelnummer: ARG81394.96
Protein function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone...
| Schlagworte: | HSP86, LAP-2, HSP90A, HSP 86, HSP90AA1, Heat shock 86 kDa, LPS-associated protein 2, Heat shock protein HSP 90-alpha,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human, goat |
1.726,00 €
HSP90alpha C-Terminal Domain TR-FRET Assay Kit
Artikelnummer: BPS-50289-1
This assay kit is designed to measure the inhibition of the HSP90alpha binding to its protein target PPID (also known as Cyclophilin D) in a homogeneous, 96 reaction format. This assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay...
| Schlagworte: | HSP90, Assay kit, HSP90a, HSP90alpha, Fret assay kit, |
| Anwendung: | Drug discovery, HTS |
| Spezies-Reaktivität: | human |
ab 1.204,00 €
Hsp90a, active human recombinant protein
Artikelnummer: BPS-50290
Active human Heat Shock Protein 90 alpha (GenBank Accession No. NM_005348), full length with C-terminal His tag, MW = 85.5 kDa, expressed in an E. coli expression system.
| Schlagworte: | LAP-2, HSP86, HSP 86, HSP90A, Heat shock 86 kDa, LPS-associated protein 2, Heat shock protein HSP 90-alpha, Renal... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 85.5 kD |
655,00 €
Radicicol
Artikelnummer: Cay13089-1
Radicicol is an inhibitor of heat shock protein 90 (Hsp90, IC50 = erb82, and mutant p53. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.Formal Name:...
| Schlagworte: | KF58332, KF9-A, Monorden, NSC 294404,... |
| Anwendung: | Hsp90 inhibitor |
| CAS | 12772-57-5 |
| MW: | 364.7 D |
ab 52,00 €
Anti-HSP90AA1
Artikelnummer: ATA-HPA047290.100
Rabbit Polyclonal HSP90AA1 Antibody against Human heat shock protein 90 alpha family class A member 1. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs:...
| Schlagworte: | Anti-HSP86, Anti-LAP-2, Anti-HSP 86, Anti-HSP90A, Anti-Heat shock 86 kDa, Anti-LPS-associated protein 2, Anti-Heat shock... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 264,00 €
17-AAG
Artikelnummer: Cay11039-1
17-AAG is an inhibitor of heat shock protein 90 (Hsp90) and a derivative of geldanamycin (Cay-13355) that selectively inhibits BT474 tumor cell Hsp90 over fibroblast Hsp90 (IC50s = 5 and 943 nM, respectively). It inhibits the growth of prostate cancer cell lines (IC50s = 25-45 nM) and promotes the degradation of...
| Schlagworte: | BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin, 17-demethoxy-17-(2-propenylamino)-geldanamycin |
| Anwendung: | Hsp90 inhibitor |
| CAS | 75747-14-7 |
| MW: | 585.7 D |
ab 56,00 €
Geldanamycin
Artikelnummer: Cay13355-1
Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression,...
| Schlagworte: | NSC 122750,... |
| Anwendung: | Antibiotic |
| CAS | 30562-34-6 |
| MW: | 560.6 D |
ab 85,00 €
17-DMAG
Artikelnummer: Cay11036-1
Geldanamycin (Cay-13355) is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor...
| Schlagworte: | Alvespimycin, KOS-1022, NSC 707545, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin |
| Anwendung: | Hsp90 inhibitor |
| CAS | 467214-20-6 |
| MW: | 616.8 D |
ab 56,00 €
PU-H71 (hydrate)
Artikelnummer: Cay11450-1
The heat shock protein 90 (HSP90) family of proteins are molecular chaperones involved in folding, activation, maturation, and assembly of different proteins, including the mediators of signal transduction and cell cycle progression. A class of inhibitors targeting HSP90 has emerged in anti-cancer therapy. PU-H71...
| Schlagworte: | 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine, hydrate |
| Anwendung: | Hsp90 inhibitor |
| CAS | 1202865-65-3 |
| MW: | 512.4 D |
ab 147,00 €
NVP-AUY922
Artikelnummer: Cay10012698-5
Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition...
| Schlagworte: | VER 52296, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide |
| Anwendung: | Hsp90 Inhibitor |
| CAS | 747412-49-3 |
| MW: | 465.5 D |
ab 228,00 €