Zu "K03462" wurden 177 Artikel gefunden!
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beta-Nicotinamide Mononucleotide
Artikelnummer: Cay16411-100
beta-Nicotinamide mononucleotide (beta-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+, Cay-16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate beta-NMN, which is subsequently...
| Schlagworte: | beta-NMN, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-pyridinium, inner salt |
| Anwendung: | NAD biosynthesis intermediate |
| CAS | 1094-61-7 |
| MW: | 334.2 D |
ab 68,00 €
Nampt (Visfatin/PBEF) (human) ELISA Kit
Artikelnummer: AG-45A-0006YEK-KI01
Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52kDA adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form...
| Schlagworte: | PBEF, NAMPT, Nampt, Visfatin, NAmPRTase, EC=2.4.2.12, Pre-B cell-enhancing factor, Pre-B-cell colony-enhancing factor 1,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 693,00 €
Anti-PBEF
Artikelnummer: A300-372A
Protein function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with...
| Schlagworte: | Anti-PBEF, Anti-NAMPT, Anti-Nampt, Anti-Visfatin, Anti-NAmPRTase, EC=2.4.2.12, Anti-Pre-B cell-enhancing factor,... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
Visfatin, FLAG Tag, human recombinant (rHuVisfatin-FLAG)
Artikelnummer: 94936.25
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). (www.uniprot.org) Produced in E.coli as a single,...
| Schlagworte: | PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256,... |
| Anwendung: | Cell biology studies |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 39573.00 D |
ab 105,00 €
Anti-Nampt (Clone OMNI 379)
Artikelnummer: Cay10813-100
Nampt is a 52 kDa adipokine secreted by adipose tissue that is involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme...
| Schlagworte: | Nicotinamide Phosphoribosyltransferase, PBEF1, Pre-B Cell Colony Enhancing Factor 1, Visfatin |
| Anwendung: | ELISA, FC, ICC, IHC, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 337,00 €
Anti-PBEF (IHC)
Artikelnummer: IHC-00011
Protein function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with...
| Schlagworte: | Anti-PBEF, Anti-NAMPT, Anti-Nampt, Anti-Visfatin, Anti-NAmPRTase, EC=2.4.2.12, Anti-Pre-B cell-enhancing factor,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
FK-866
Artikelnummer: Cay13287-5
FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...
| Schlagworte: | K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
| Anwendung: | NAMPT inhibitor |
| CAS | 658084-64-1 |
| MW: | 391.5 D |
ab 40,00 €
Anti-Visfatin
Artikelnummer: A300-778A
Protein function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with...
| Schlagworte: | Anti-PBEF, Anti-NAMPT, Anti-Nampt, Anti-Visfatin, Anti-NAmPRTase, EC=2.4.2.12, Anti-Pre-B cell-enhancing factor,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-Visfatin
Artikelnummer: A300-779A
Protein function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with...
| Schlagworte: | Anti-PBEF, Anti-NAMPT, Anti-Nampt, Anti-Visfatin, Anti-NAmPRTase, EC=2.4.2.12, Anti-Pre-B cell-enhancing factor,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
FK-866
Artikelnummer: AG-CR1-0011-M001
Nampt/visfatin inhibitor, Inhibitor of NAD biosynthesis, Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0,4 nM and Ki = 0,3 nM, respectively), Apoptosis inducer, Autophagy inducer, Causes premature senescence, Angiogenesis inhibitor.
| Schlagworte: | K 22.175, FK866, APO866, WK175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
| Anwendung: | Nampt/visfatin inhibitor |
| CAS | 658084-64-1 |
| MW: | 391,5 D |
ab 44,00 €
CHS-828
Artikelnummer: AG-CR1-0064-M005
Antitumor compound, Programmed cell death inducer, Cytotoxic, Antiproliferative, p53 activator, IkappaB kinase inhibitor, NF-kappaB inhibitor, Nampt/visfatin inhibitor.
| Schlagworte: | GMX1778, (E)-1-[6-(4-chlorophenoxy)hexyl]-2-cyano-3-(pyridin-4-yl)guanidine |
| Anwendung: | Apoptosis inducer |
| CAS | 200484-11-3 |
| MW: | 371,9 D |
ab 61,00 €
GNE-617
Artikelnummer: Cay22463-1
GNE-617 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt, IC50 = 5 nM). It has antiproliferative activity in U251 glioblastoma, HT-1080 fibrosarcoma, PC3 prostate, MiaPaCa2 pancreatic, and HCT116 colon cancer cell lines (IC50s = 1.8, 2.1, 2.7, 7.4, and 2.0 nM, respectively). In a U251 mouse...
| Schlagworte: | N-[[4-[(3,5-difluorophenyl)sulfonyl]phenyl]methyl]-imidazo[1,2-a]pyridine-6-carboxamide |
| Anwendung: | NAMPT inhibitor |
| CAS | 1362154-70-8 |
| MW: | 427.4 D |
ab 52,00 €