Zu "K03259" wurden 146 Artikel gefunden!
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4EGI-1
Artikelnummer: Cay15362-1
In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G. 4EGI-1 is an inhibitor of the initiation...
| Schlagworte: | eIF4E/eIF4G Interaction Inhibitor, alpha-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic... |
| Anwendung: | Translation initiation inhibitor |
| CAS | 315706-13-9 |
| MW: | 451.3 D |
ab 67,00 €
Anti-eIF4E
Artikelnummer: A301-154A
Protein function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and...
| Schlagworte: | Anti-eIF4E, Anti-EIF4E, Anti-eIF-4E, Anti-EIF4EL1, Anti-eIF-4F 25 kDa subunit, Anti-mRNA cap-binding protein,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
Briciclib
Artikelnummer: Cay22989-1
Briciclib is a water soluble derivative of ON 013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E). Briciclib inhibits proliferation of JEKO-1 and Mino mantle cell leukemia (MCL), MCF-7 and MDA-MB-231 breast, AGS gastric, and OE19, OE33, and LFO-1 esophageal cancer...
| Schlagworte: | ON-014185, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-phenol 1-(dihydrogen phosphate) |
| Anwendung: | eIF4E binding, cap-dependent translation inhibitor |
| CAS | 865783-99-9 |
| MW: | 474.4 D |
ab 56,00 €
Anti-phospho-eIF4E (Ser209)
Artikelnummer: ARG51723.100
Protein function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and...
| Schlagworte: | Anti-phospho-EIF4E, Anti-phospho-eIF4E, Anti-phospho-eIF-4E, Anti-phospho-EIF4EL1, Anti-phospho-eIF-4F 25 kDa subunit,... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 471,00 €
eIF4E (human recombinant, GST-tagged)
Artikelnummer: Cay15564-100
Eukaryotic translation initiation factor 4E (eIF4E) is a component of the eIF4 complex that specifically binds to the methy-7-guanosine cap structure at the 5' end of eukaryotic mRNA to initiate translation. Nuclear eIF4E promotes export of mRNAs that contain the eIF4E sensitivity element (4E-SE) to the cytosol...
| Schlagworte: | eIF-4F 25 kDa subunit, Eukaryotic Translation Initiation Factor 4E, mRNA Cap-binding Protein |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
677,00 €
4E1RCat
Artikelnummer: Cay18399-1
4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions. It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 µM. 4E1RCat was shown to reverse tumor chemoresistance in a mouse...
| Schlagworte: | eIF4E/eIF4G Interaction Inhibitor II,... |
| Anwendung: | Protein translation inhibitor, eIF4E:eIF4G & eIF4E:4E-BP1 interaction inhibitor |
| CAS | 328998-25-0 |
| MW: | 478.5 D |
ab 56,00 €
eIF4E (human recombinant, His-tagged)
Artikelnummer: Cay25150-100
Eukaryotic translation initiation factor 4E (eIF4E) is a component of the eIF4 complex that specifically binds to the methyl-7-guanosine cap structure at the 5' end of eukaryotic mRNA to initiate translation. Nuclear eIF4E promotes export of mRNAs that contain the eIF4E sensitivity element (4E-SE) to the cytosol...
| Schlagworte: | eIF4E, eIF4E, eIF-4E, eIF-4E, EIF4EL1, eIF-4F 25 kDa subunit, eIF-4F 25 kDa subunit, mRNA cap-binding protein... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
712,00 €
4E2RCat
Artikelnummer: Cay35894-10
4E2RCat is an inhibitor of the protein-protein interaction between eukaryotic translation initiation factor 4E (eIF4E) and eIF4G (IC50 = 13.5 µM). It reduces mRNA translation without inducing apoptosis in L-132 cells when used at a concentration 12.5 µM. 4E2RCat (6 µM) decreases intracellular and extracellular...
| Schlagworte: | 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid |
| Anwendung: | eIF4E-eIF4G protein-protein interaction inhibitor |
| CAS | 432499-63-3 |
| MW: | 455.9 D |
ab 38,00 €
Anti-eIF4E
Artikelnummer: ARG51206.100
Protein function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and...
| Schlagworte: | Anti-EIF4E, Anti-eIF4E, Anti-eIF-4E, Anti-EIF4EL1, Anti-eIF-4F 25 kDa subunit, Anti-mRNA cap-binding protein,... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 471,00 €
Anti-eIF4E
Artikelnummer: A301-153A
Protein function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and...
| Schlagworte: | Anti-eIF4E, Anti-EIF4E, Anti-eIF-4E, Anti-EIF4EL1, Anti-eIF-4F 25 kDa subunit, Anti-mRNA cap-binding protein,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
eIF4E
Artikelnummer: BPS-40530
Human Eif4e (eukaryotic translation initiation factor 4E) (GenBank Accession No. NM_001968), (amino-acids 2-216) with N-terminal GST tag, MW= 51 kDa, expressed in E. coli expression system.
| Schlagworte: | eIF4E, eIF-4E, EIF4EL1, eIF-4F 25 kDa subunit, mRNA cap-binding protein, Eukaryotic translation initiation factor 4E, |
| Anwendung: | MNK1 kinase substrate |
| MW: | 51 kD |
640,00 €
eIF4E (human, recombinant)
Artikelnummer: Cay15137-100
Eukaryotic translation initiation factor 4E (eIF4E) is a component of the eIF4 complex that specifically binds to the methyl-7-guanosine cap structure at the 5' end of eukaryotic mRNA to initiate translation. Nuclear eIF4E promotes export of mRNAs that contain the eIF4E sensitivity element (4E-SE) to the cytosol...
| Schlagworte: | eIF4E, eIF4E, eIF-4E, eIF-4E, EIF4EL1, eIF-4F 25 kDa subunit, eIF-4F 25 kDa subunit, mRNA cap-binding protein... |
| Anwendung: | Binding assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
677,00 €