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SN-38-d3
SN-38-d3

Artikelnummer: Cay40133-1

SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Cay-15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase...
Schlagworte: 7-ethyl-10-hydroxy-20(S)-Camptothecin-d3, 7-Ethyl-10-Hydroxycamptothecin-d3,...
Anwendung: GC-MS, LC-MS internal standard, quantification, DNA topoisomerase I inhibitor
CAS 718612-49-8
MW: 395.4 D
909,00 €
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Camptothecin
Camptothecin

Artikelnummer: Cay11694-50

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
Schlagworte: MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Anwendung: Topoisomerase inhibitor
CAS 7689-03-4
MW: 348.4 D
ab 35,00 €
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Human TOP1 (Topoisomerase I) ELISA Kit
Human TOP1 (Topoisomerase I) ELISA Kit

Artikelnummer: ELK-ELK3045.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TOP1. Next,...
Schlagworte: TOP1, DNA topoisomerase I, DNA topoisomerase 1
Anwendung: ELISA
Spezies-Reaktivität: human
ab 365,00 €
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Rat TOP1 (Topoisomerase I) ELISA Kit
Rat TOP1 (Topoisomerase I) ELISA Kit

Artikelnummer: ELK-ELK7553.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TOP1. Next,...
Schlagworte: Top1, DNA topoisomerase I, DNA topoisomerase 1
Anwendung: ELISA
Spezies-Reaktivität: rat
ab 365,00 €
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Mouse TOP1 (Topoisomerase I) ELISA Kit
Mouse TOP1 (Topoisomerase I) ELISA Kit

Artikelnummer: ELK-ELK7019.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TOP1. Next,...
Schlagworte: Top1, Top-1, DNA topoisomerase I, DNA topoisomerase 1
Anwendung: ELISA
Spezies-Reaktivität: mouse
ab 365,00 €
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Topotecan (hydrochloride)
Topotecan (hydrochloride)

Artikelnummer: Cay14129-5

Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....
Schlagworte: NSC 609669, SKF 104864A,...
Anwendung: Topoisomerase I inhibitor
CAS 119413-54-6
MW: 457.9 D
ab 42,00 €
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SN-38
SN-38

Artikelnummer: Cay15632-5

SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal...
Schlagworte: 7-ethyl-10-hydroxy-20(S)-Camptothecin, 7-Ethyl-10-Hydroxycamptothecin, NK 012,...
Anwendung: Potent DNA topoisomerase I inhibitor
CAS 86639-52-3
MW: 392.4 D
ab 66,00 €
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Irinotecan (hydrochloride hydrate)
Irinotecan (hydrochloride hydrate)

Artikelnummer: Cay14180-25

Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates...
Schlagworte: [1,4'-bipiperidine]-1'-carboxylic acid,...
Anwendung: Topoisomerase I inhibitor
CAS 136572-09-3
MW: 677.2 D
ab 66,00 €
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Rebeccamycin
Rebeccamycin

Artikelnummer: BVT-0139-C250

Antibiotic, Weak topoisomerase I (Topo I) inhibitor, Structurally similar to staurosporine, Does not show any inhibitory activity against protein kinases, Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Isolated from...
Schlagworte: NSC 359079, BRN 4732638
Anwendung: Topoisomerase I (Topo I) inhibitor
CAS 93908-02-2
MW: 570,4 D
ab 95,00 €
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Irinotecan
Irinotecan

Artikelnummer: LKT-I6932.10

Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore...
Schlagworte: CPT-11
Anwendung: Topoisomerase I inhibitor
CAS 97682-44-5
MW: 586,68 D
ab 90,00 €
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Anti-TOP1
Anti-TOP1

Artikelnummer: A302-589A

Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is...
Schlagworte: Anti-TOP1, EC=5.99.1.2, Anti-DNA topoisomerase I, Anti-DNA topoisomerase 1
Anwendung: WB, IP
Wirt: Rabbit
Spezies-Reaktivität: human
ab 164,00 €
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Camptothecin, 10-hydroxy
Camptothecin, 10-hydroxy

Artikelnummer: LKT-C0155.25

A potent cytotoxic agent, which inhibits DNA topoisomerase I, induces strand breaks in chromosomal DNA and induces apoptosis.
Anwendung: DNA topoisomerase I inhibitor
CAS 64439-81-2
MW: 364,35 D
ab 99,00 €
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