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Zu "K03163" wurden 98 Artikel gefunden!
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Artikelnummer: Cay40133-1
SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Cay-15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase...
Schlagworte: | 7-ethyl-10-hydroxy-20(S)-Camptothecin-d3, 7-Ethyl-10-Hydroxycamptothecin-d3,... |
Anwendung: | GC-MS, LC-MS internal standard, quantification, DNA topoisomerase I inhibitor |
CAS | 718612-49-8 |
MW: | 395.4 D |
909,00 €
Artikelnummer: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
Schlagworte: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
Anwendung: | Topoisomerase inhibitor |
CAS | 7689-03-4 |
MW: | 348.4 D |
ab 35,00 €
Artikelnummer: ELK-ELK3045.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TOP1. Next,...
Schlagworte: | TOP1, DNA topoisomerase I, DNA topoisomerase 1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK7553.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TOP1. Next,...
Schlagworte: | Top1, DNA topoisomerase I, DNA topoisomerase 1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: ELK-ELK7019.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TOP1. Next,...
Schlagworte: | Top1, Top-1, DNA topoisomerase I, DNA topoisomerase 1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: Cay14129-5
Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....
Schlagworte: | NSC 609669, SKF 104864A,... |
Anwendung: | Topoisomerase I inhibitor |
CAS | 119413-54-6 |
MW: | 457.9 D |
ab 42,00 €
Artikelnummer: Cay15632-5
SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal...
Schlagworte: | 7-ethyl-10-hydroxy-20(S)-Camptothecin, 7-Ethyl-10-Hydroxycamptothecin, NK 012,... |
Anwendung: | Potent DNA topoisomerase I inhibitor |
CAS | 86639-52-3 |
MW: | 392.4 D |
ab 66,00 €
Artikelnummer: Cay14180-25
Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates...
Schlagworte: | [1,4'-bipiperidine]-1'-carboxylic acid,... |
Anwendung: | Topoisomerase I inhibitor |
CAS | 136572-09-3 |
MW: | 677.2 D |
ab 66,00 €
Artikelnummer: BVT-0139-C250
Antibiotic, Weak topoisomerase I (Topo I) inhibitor, Structurally similar to staurosporine, Does not show any inhibitory activity against protein kinases, Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Isolated from...
Schlagworte: | NSC 359079, BRN 4732638 |
Anwendung: | Topoisomerase I (Topo I) inhibitor |
CAS | 93908-02-2 |
MW: | 570,4 D |
ab 95,00 €
Artikelnummer: LKT-I6932.10
Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore...
Schlagworte: | CPT-11 |
Anwendung: | Topoisomerase I inhibitor |
CAS | 97682-44-5 |
MW: | 586,68 D |
ab 90,00 €
Artikelnummer: A302-589A
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is...
Schlagworte: | Anti-TOP1, EC=5.99.1.2, Anti-DNA topoisomerase I, Anti-DNA topoisomerase 1 |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: LKT-C0155.25
A potent cytotoxic agent, which inhibits DNA topoisomerase I, induces strand breaks in chromosomal DNA and induces apoptosis.
Anwendung: | DNA topoisomerase I inhibitor |
CAS | 64439-81-2 |
MW: | 364,35 D |
ab 99,00 €