Zu "K03163" wurden 182 Artikel gefunden!
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NEU
Anti-Exatecan/Dxd
Artikelnummer: Cay45399-100
Immunogen: Exatecan-KLH Host: Rabbit Species Reactivity: Species independent Cross Reactivity: (+++) Exatecan, (++) Deruxtecan, (-) Other warheads Applications: ELISA, WB. SMILES: . InChi Code: . InChi Key:
| Schlagworte: | DX 8951f |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | broad |
468,00 €
Anti-TOP1MT / DNA topoisomerase 1 mitochondrial
Artikelnummer: NSJ-FY12093
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TOP1MT antibody detects DNA topoisomerase 1 mitochondrial, encoded by the TOP1MT gene. DNA topoisomerase 1 mitochondrial is an enzyme located in the mitochondrial matrix that relaxes supercoiled mitochondrial DNA, enabling replication,...
| Schlagworte: | Anti-TOP1MT, Anti-DNA topoisomerase I, mitochondrial, TOP1MT Antibody / DNA topoisomerase 1 mitochondrial |
| Anwendung: | WB, IHC, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
790,00 €
Exatecan-amide-cyclopropanol
Artikelnummer: Cay44470-1
Exatecan-amide-cyclopropanol is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) that has been used as a building block in the synthesis of antibody-drug conjugates (ADCs) with anticancer activity. Formal Name:...
| Schlagworte: | N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indol... |
| Anwendung: | Exatecan derivative, ADC building block |
| CAS | 2414254-34-3 |
| MW: | 519.53 D |
ab 61,00 €
Mal-PEG8-Val-Ala-PAB-Exatecan
Artikelnummer: Cay44595-1
Mal-PEG8-Val-Ala-PAB-Exatecan is a reactive drug-linker molecule containing the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a maleimide-terminal linker. Formal Name:...
| Schlagworte: | 4-((2S,5S)-37-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-2-methyl-4,7,35-trioxo-10,13,16,19,22,25,28,31-octaoxa-3,... |
| Anwendung: | Exatecan containing reactive drug-linker molecule |
| CAS | 2679821-39-5 |
| MW: | 1329.44 D |
ab 134,00 €
Camptothecin
Artikelnummer: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
| Schlagworte: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Anwendung: | Topoisomerase inhibitor |
| CAS | 7689-03-4 |
| MW: | 348.4 D |
ab 40,00 €
Ac-Exatecan
Artikelnummer: Cay44473-10
Ac-Exatecan is an acetylated derivative of exatecan (Cay-35452), a DNA topoisomerase I inhibitor. InChI: InChI=1S/C26H24FN3O5/c1-4-26(34)16-7-20-23-14(9-30(20)24(32)15(16)10-35-25(26)33)22-18(28-12(3)31)6-5-13-11(2)17(27)8-19(29-23)21(13)22/h7-8,18,34H,4-6,9-10H2,1-3H3,(H,28,31)/t18-,26-/m0/s1 InChIKey:...
| Schlagworte: | N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indol... |
| Anwendung: | Acetylated exatecan derivative |
| CAS | 2922852-48-8 |
| MW: | 477.49 D |
ab 40,00 €
Topotecan (hydrochloride)
Artikelnummer: Cay14129-5
Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....
| Schlagworte: | NSC 609669, SKF 104864A,... |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 119413-54-6 |
| MW: | 457.9 D |
ab 48,00 €
SN-38
Artikelnummer: Cay15632-5
SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal...
| Schlagworte: | 7-ethyl-10-hydroxy-20(S)-Camptothecin, 7-Ethyl-10-Hydroxycamptothecin, NK 012,... |
| Anwendung: | Potent DNA topoisomerase I inhibitor |
| CAS | 86639-52-3 |
| MW: | 392.4 D |
ab 73,00 €
Irinotecan (hydrochloride hydrate)
Artikelnummer: Cay14180-25
Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates...
| Schlagworte: | [1,4'-bipiperidine]-1'-carboxylic acid,... |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 136572-09-3 |
| MW: | 677.2 D |
ab 73,00 €
Rebeccamycin
Artikelnummer: BVT-0139-C250
Antibiotic, Weak topoisomerase I (Topo I) inhibitor, Structurally similar to staurosporine, Does not show any inhibitory activity against protein kinases, Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Isolated from...
| Schlagworte: | NSC 359079, BRN 4732638 |
| Anwendung: | Topoisomerase I (Topo I) inhibitor |
| CAS | 93908-02-2 |
| MW: | 570,4 D |
ab 100,00 €
Irinotecan
Artikelnummer: LKT-I6932.10
Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore...
| Schlagworte: | CPT-11 |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 97682-44-5 |
| MW: | 586,68 D |
ab 94,00 €
Anti-TOP1
Artikelnummer: A302-589A
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is...
| Schlagworte: | Anti-TOP1, EC=5.99.1.2, Anti-DNA topoisomerase I, Anti-DNA topoisomerase 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €