Zu "K03163" wurden 195 Artikel gefunden!
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NEU
Val-Ala-PABC-Exatecan
Artikelnummer: Cay44443-10
Val-Ala-PABC-Exatecan is a drug-linker molecule containing the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a Val-Ala-p-aminobenzyl carbamate (Val-Ala-PABC) linker. It has been used in the synthesis of Mal-PEG8-Val-Ala-PAB-exatecan (Cay-44595), which has been incorporated into antibody-drug conjugates...
| Schlagworte: | L-valyl-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[... |
| Anwendung: | DNA topoisomerase I inhibitor-drug-linker molecule |
| CAS | 2845164-91-0 |
| MW: | 754.82 D |
ab 119,00 €
NEU
10-hydroxy Camptothecin
Artikelnummer: Cay46297-100
10-hydroxy Camptothecin is an alkaloid originally isolated from C. acuminata that has DNA topoisomerase I inhibitory and anticancer activities. It inhibits DNA topoisomerase I (IC50 = 1 µM), reduces the proliferation of L1210 leukemia cells (IC50 = 18 nM), and increases survival by 78% in an L1210 murine leukemia...
| Schlagworte: | 10-HCPT, DL-10-hydroxy Camptothecin, 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Anwendung: | Alkaloid, DNA topoisomerase I inhibitory / anticancer agent |
| CAS | 64439-81-2 |
| MW: | 364.36 D |
ab 69,00 €
Camptothecin
Artikelnummer: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
| Schlagworte: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Anwendung: | Topoisomerase inhibitor |
| CAS | 7689-03-4 |
| MW: | 348.4 D |
ab 42,00 €
Coralyne (chloride)
Artikelnummer: Cay45715-10
Coralyne is a DNA topoisomerase I poison. It inhibits DNA topoisomerase I via stabilization of the DNA-enzyme complex and inhibition of DNA relaxation. It is selective for DNA topoisomerase I over DNA topoisomerase II at 100 µg/ml. Coralyne (100-400 mg/kg) increases survival in P388 and L1210 murine leukemia...
| Schlagworte: | 2,3,10,11-tetramethoxy-8-methyl-dibenzo[a,g]quinolizinium, monochloride |
| Anwendung: | DNA topoisomerase I poison |
| CAS | 38989-38-7 |
| MW: | 399.87 D |
ab 122,00 €
Deruxtecan
Artikelnummer: BPS-84320-1
Deruxtecan is a linker-payload conjugate made of a derivative of DX-8951 and the maleimide-GGFC peptide linker. It is used to synthetize ADCs (antibody drug conjugates), such as trastuzumab deruxtecan and patritumab deruxtecan. ADC (antibody drug conjugates) are a promising therapeutic strategy. ADCs are composed of...
| Anwendung: | ADC (antibody drug conjugate) preparation |
| CAS | 1599440-13-7 |
| MW: | 1034.05 D |
ab 614,00 €
Exatecan
Artikelnummer: BPS-84321-1
Exatecan, also known as DX-8951, is a DNA topoisomerase I inhibitor. ADC (antibody drug conjugates) are a promising therapeutic strategy. ADCs are composed of an antibody that can bind to a target in the cells, such as HER3 (human epidermal growth factor receptor 3), a linker and a payload (cytotoxic drug)....
| Anwendung: | ADC preparation, in vitro inhibition studies |
| CAS | 171335-80-1 |
| MW: | 435.45 |
ab 270,00 €
Anti-Exatecan (Clone 1B2)
Artikelnummer: Cay44715-100
Exatecan is a DNA topoisomerase I inhibitor that inhibits cancer cell growth in vitro and reduces tumor growth in vivo. It has been used as the cytotoxic payload component of antibody-drug conjugates (ADCs), which have been used to selectively target and destroy cancer cells in vitro and in vivo in animal models....
| Schlagworte: | DX 8951f |
| Anwendung: | ELISA, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | broad |
445,00 €
TOP1 Protein, Mouse, Recombinant (aa 193-767, His)
Artikelnummer: TGM-TMPY-07229-100ug
Description: TOP1 Protein, Mouse, Recombinant (aa 193-767, His) is expressed in Baculovirus-Insect Cells. The accession number is Q04750.
| Schlagworte: | D130064I21Rik , Top1 , Top-1 |
| MW: | 69.48 kD |
ab 80,00 €
Exatecan-amide-cyclopropanol
Artikelnummer: Cay44470-1
Exatecan-amide-cyclopropanol is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) that has been used as a building block in the synthesis of antibody-drug conjugates (ADCs) with anticancer activity. Formal Name:...
| Schlagworte: | N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indol... |
| Anwendung: | Exatecan derivative, ADC building block |
| CAS | 2414254-34-3 |
| MW: | 519.53 D |
ab 64,00 €
Mal-PEG8-Val-Ala-PAB-Exatecan
Artikelnummer: Cay44595-1
Mal-PEG8-Val-Ala-PAB-Exatecan is a reactive drug-linker molecule containing the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a maleimide-terminal linker. Formal Name:...
| Schlagworte: | 4-((2S,5S)-37-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-2-methyl-4,7,35-trioxo-10,13,16,19,22,25,28,31-octaoxa-3,... |
| Anwendung: | Exatecan containing reactive drug-linker molecule |
| CAS | 2679821-39-5 |
| MW: | 1329.44 D |
ab 139,00 €
Anti-Exatecan/Dxd
Artikelnummer: Cay45399-100
Immunogen: Exatecan-KLH Host: Rabbit Species Reactivity: Species independent Cross Reactivity: (+++) Exatecan, (++) Deruxtecan, (-) Other warheads Applications: ELISA, WB. SMILES: . InChi Code: . InChi Key:
| Schlagworte: | DX 8951f |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | broad |
483,00 €
Anti-TOP1MT / DNA topoisomerase 1 mitochondrial
Artikelnummer: NSJ-FY12093
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TOP1MT antibody detects DNA topoisomerase 1 mitochondrial, encoded by the TOP1MT gene. DNA topoisomerase 1 mitochondrial is an enzyme located in the mitochondrial matrix that relaxes supercoiled mitochondrial DNA, enabling replication,...
| Schlagworte: | Anti-TOP1MT, Anti-DNA topoisomerase I, mitochondrial, TOP1MT Antibody / DNA topoisomerase 1 mitochondrial |
| Anwendung: | WB, IHC, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
790,00 €