Zu "K02861" wurden 106 Artikel gefunden!
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Anti-Recombinant RIP, clone 6G10
Artikelnummer: E-AN301086L.100
ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation...
| Schlagworte: | Anti-RIPK1, Anti-Cell death protein RIP, Anti-Receptor-interacting protein 1, Anti-Receptor-interacting... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 258,00 €
Necrostatin-1
Artikelnummer: Cay11658-5
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-alpha (TNF-alpha) induced...
| Schlagworte: | Nec-1, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Anwendung: | RIP1 kinase inhibitor |
| CAS | 4311-88-0 |
| MW: | 259.3 D |
ab 50,00 €
(±)-Necrostatin-2
Artikelnummer: Cay20924-1
(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner. Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS)....
| Schlagworte: | 7-Cl-O-Nec-1, Nec-1s, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione |
| Anwendung: | Cell-permeable RIP1 inhibitor |
| CAS | 852391-15-2 |
| MW: | 277.7 D |
ab 60,00 €
Necrostatin-1 Inactive Control
Artikelnummer: Cay21192-50
Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1 (Nec-1, Cay-11658), a RIP1 kinase inhibitor. While both Nec-1 and Nec-1i inhibit the immune regulator indoleamine 2,3-dioxygenase, Nec1i is ~100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent...
| Schlagworte: | Nec-1i, 5-(1H-indol-3-ylmethyl)-2-thioxo-4-imidazolidinone |
| Anwendung: | Inactive RIPK1 inhibitor control |
| CAS | 64419-92-7 |
| MW: | 245.3 D |
ab 52,00 €
RIPK1, GST-Tag
Artikelnummer: BPS-40371
Human RIPK1, also known as RCK and MAP3K19, GenBank Accession No. NM_003804, a.a. 1-327, with N-terminal GST-tag, MW=63 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
| Schlagworte: | RIP-1, Cell death protein RIP, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 63 kD |
633,00 €
Anti-phospho-RIPK1 / RIP1 (Ser166), clone YJY-1-5
Artikelnummer: ARG66476.100
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:12654725, PubMed:19590578). Upon activation of TNFR1 by the TNF-alpha family cytokines,...
| Schlagworte: | Anti-phospho-Rinp, Anti-phospho-Ripk1, Anti-phospho-RIP-1, Anti-phospho-Cell death protein RIP,... |
| Anwendung: | ICC, IF, IHC (frozen), IHC (paraffin), IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
658,00 €
Necrostatin-5
Artikelnummer: Cay10527-5
Necrostatin-5 is a RIP1 kinase inhibitor. It inhibits phosphorylation of RIP1 in Jurkat cells when used at concentrations of 10 and 30 µM. Necrostatin-5 inhibits TNF-alpha-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD, EC50 = 0.24 µM), a modification that prevents caspase...
| Schlagworte: | Nec-5, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile |
| Anwendung: | RIP1 kinase inhibitor |
| CAS | 337349-54-9 |
| MW: | 383.5 D |
ab 73,00 €
GSK481
Artikelnummer: Cay20308-1
GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM. It is selective for RIP1 over a panel of over 450 other kinases, including RIP3. GSK481 inhibits RIP1 from human and...
| Schlagworte: | 5-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-isoxazolecarboxamide |
| Anwendung: | RIP1 Ser166 phosphorylation inhibitor |
| CAS | 1622849-58-4 |
| MW: | 377.4 D |
ab 49,00 €
Cl-Necrostatin-1
Artikelnummer: Cay11656-10
Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1). It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 µM. It also inhibits TNF-alpha-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD, EC50 = 180 nM), a modification that...
| Schlagworte: | 7-Cl-Nec-1, 7-Cl-Necrostatin-1, Nec-1f, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo-4-imidazolidinone |
| Anwendung: | RIPK1 inhibitor |
| CAS | 862377-51-3 |
| MW: | 293.8 D |
ab 73,00 €
Anti-RIP1
Artikelnummer: 600-401-EA2
Anti-RIP1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RIP1 from other sources has not been determined. Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors...
| Schlagworte: | Anti-RIP, Anti-RIP-1, Anti-RIPK1, EC=2.7.11.1, Anti-Cell death protein RIP, Anti-Receptor-interacting protein 1,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
848,00 €
Anti-RIPK1 / RIP1
Artikelnummer: ARG40183.100
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1...
| Schlagworte: | Anti-RIP, Anti-RIP-1, Anti-RIPK1, Anti-Cell death protein RIP, Anti-Receptor-interacting protein 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
GSK2982772
Artikelnummer: Cay29230-5
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1, IC50s = 16 and 2,500 nM for the human and mouse enzymes, respectively). It is greater than 10,000-fold selective for RIPK1 over a panel of 339 kinases at 10 µM. GSK2982772 inhibits necrotic cell death induced by a combination of...
| Schlagworte: | 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide |
| Anwendung: | RIPK1 inhibitor |
| CAS | 1622848-92-3 |
| MW: | 377.4 D |
ab 93,00 €