Zu "K02599" wurden 137 Artikel gefunden!
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Compound E
Artikelnummer: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
| Schlagworte: | gamma-Secretase Inhibitor XXI,... |
| Anwendung: | gamma-Secretase inhibitor |
| CAS | 209986-17-4 |
| MW: | 490.5 D |
ab 281,00 €
Anti-Recombinant Notch1, clone 8D5
Artikelnummer: E-AN301057L.100
Notch 1(NOTCH1) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of...
| Schlagworte: | Anti-NOTCH1, Anti-Neurogenic locus notch homolog protein 1, Anti-Translocation-associated notch protein TAN-1, Recombinant... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Notch 1, His & Avi, Human
Artikelnummer: GSC-Z05701-100
Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation...
| Schlagworte: | NOTCH1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1 |
| Ursprungsart: | human |
| MW: | 56.5 kD |
ab 457,00 €
![Notch 1[Biotin], His & Avi, Human](https://www.biomol.com/media/image/6c/a1/a1/GSC-Z04572-100_200x200.png "Notch 1[Biotin], His & Avi, Human")
Notch 1[Biotin], His & Avi, Human
Artikelnummer: GSC-Z04572-100
Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation...
| Schlagworte: | NOTCH1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1 |
| Ursprungsart: | human |
| MW: | 56.5 kD |
ab 887,00 €
Notch Reporter Assay Kit (cAMP/PKA pathway)
Artikelnummer: BPS-60509
Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready Notch1 NICD expression vector and CSL (CBF1/RBP-Jkappa) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a...
| Schlagworte: | Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter, |
| Anwendung: | Notch activity assays |
931,00 €
Anti-Notch1
Artikelnummer: A301-895A
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
| Schlagworte: | Anti-TAN1, Anti-NOTCH1 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Compound E
Artikelnummer: AG-CR1-0081-M005
Cell permeable, potent, selective, non-transition state and non-competitive and gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
| Schlagworte: | (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 209986-17-4 |
| MW: | 490,5 D |
ab 99,00 €
Anti-Notch1, cleaved, NT
Artikelnummer: 100-401-407
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
| Schlagworte: | Anti-TAN1, Anti-NOTCH1 |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
733,00 €
Notch1 Pathway Reporter Kit (Human)
Artikelnummer: BPS-79503
Notch Pathway Reporter kit is designed for monitoring the activity of the Notch signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for Human NOTCH1 that has a deletion of the entire extracellular domain, leaving the transmembrane and intracellular domains intact (Notch1DE)....
| Schlagworte: | Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter, Cell based... |
| Anwendung: | Notch signaling pathway activity monitoring, activator / inhibitor screening |
| Spezies-Reaktivität: | human |
1.027,00 €
Crenigacestat
Artikelnummer: Cay27919-1
Crenigacestat is an orally bioavailable Notch inhibitor. It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells. Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.Formal Name:...
| Schlagworte: | LY3039478,... |
| Anwendung: | Notch inhibitor, antineoplastic |
| CAS | 1421438-81-4 |
| MW: | 464.4 D |
ab 67,00 €
Anti-Notch1 (IHC)
Artikelnummer: IHC-00538
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
| Schlagworte: | Anti-TAN1, Anti-NOTCH1 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Notch reporter cell line, 1.5x10(6) cells
Artikelnummer: BPS-60652
The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the...
| Schlagworte: | Notch, NICD, PKA, cAMP, luciferase reporter, |
| Anwendung: | Notch signaling assays, inhibitor screening |
| Wirt: | HEK293 |
| Spezies-Reaktivität: | human |
9.115,00 €