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Anti-Recombinant PRMT5, clone A338
Artikelnummer: E-AN301635L.100
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and...
| Schlagworte: | Anti-PRMT5, Anti-Jak-binding protein 1, Anti-72 kDa ICln-binding protein, Anti-Shk1 kinase-binding protein 1 homolog,... |
| Anwendung: | WB, IHC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
PF-06939999 (hydrochloride)
Artikelnummer: Cay44357-1
PF-06939999 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, Ki = <5 pM). It is selective for PRMT5 over a panel of 22 additional protein methyltransferases and a panel of 40 kinases at 10 µM. PF-06939999 decreases global symmetric dimethyl arginine levels (IC50 = 1. nM) but does not affect histone...
| Schlagworte: | PRMT5 Inhibitor 3, PRMT5-IN-3, Protein Arginine Methyltransferase 5 Inhibitor 3, Protein Arginine Methyltransferase 5-IN-3 |
| Anwendung: | PRMT5 inhibitor |
| MW: | 521.3 D |
ab 178,00 €
PF-06855800
Artikelnummer: Cay43630-1
PF-06855800 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, Ki = 11 pM). It is selective for PRMT5 over a panel of 22 additional protein methyltransferases and a panel of 40 kinases at 10 µM. PF-06855800 inhibits the proliferation of A2780 ovarian cancer cells (IC50 = 3.3 nM). It also inhibits the...
| Schlagworte: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1989620-04-3 |
| MW: | 394.79 D |
ab 147,00 €
LLY-284
Artikelnummer: Cay43141-1
LLY-284 is a diastereomer of the protein arginine methyltransferase 5 (PRMT5) inhibitor LLY-283 (Cay-21596). It weakly inhibits PRMT5 (IC50 = 1,074 nM). LLY-284 (100 µM) inhibits the asexual growth of P. falciparum in vitro.. Solulibility: DMSO: Soluble: = 10 mg/ml: Ethanol: Soluble: = 10 mg/ml.
| Schlagworte: | 7-[(5S)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | Protein arginine methyltransferase 5 (PRMT5) inhibitor LLY-283 diastereomer |
| CAS | 2226515-75-7 |
| MW: | 342.36 D |
ab 44,00 €
Anti-PRMT5
Artikelnummer: A300-850A
Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...
| Schlagworte: | Anti-PRMT5, Anti-HRMT1L5 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
PRMT5 (HEK293), active human recombinant protein
Artikelnummer: BPS-51045
Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a FreeStyle 293-F cells.
| Schlagworte: | PRMT5, HRMT1L5, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 73 kD |
894,00 €
PRMT5 (Sf9), active human recombinant protein
Artikelnummer: BPS-51048
Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PRMT5, HRMT1L5, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 73 kD |
775,00 €
EPZ015666
Artikelnummer: Cay17285-1
Protein arginine methyltransferases (PRMTs) target nuclear and cytoplasmic substrates and can alter protein actions and gene expression. PRMT5, which can methylate histones H2A, H3, and H4, ribonucleoproteins, and other proteins, is upregulated in several human cancers, including lymphomas. Moreover, suppression of...
| Schlagworte: | GSK3235025, N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1616391-65-1 |
| MW: | 383.4 D |
ab 73,00 €
Anti-PRMT5
Artikelnummer: A300-849A
Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...
| Schlagworte: | Anti-PRMT5, Anti-HRMT1L5 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
GSK591
Artikelnummer: Cay18354-1
GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric...
| Schlagworte: | EPZ015866, GSK3203591, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide |
| Anwendung: | PRMT5 chemical probe, PRMT5/MEP50 complex inhibitor |
| CAS | 1616391-87-7 |
| MW: | 380.5 D |
ab 49,00 €
LLY-283
Artikelnummer: Cay21596-1
LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 µM. It reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric,...
| Schlagworte: | 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | PRMT5 inhibitor |
| CAS | 2040291-27-6 |
| MW: | 342.4 D |
ab 49,00 €
PRMT5 chemiluminescent assay kit
Artikelnummer: BPS-52002L
The PRMT5 Direct Activity Assay kit is designed to measure PRMT5 activity using purified PRMT5 or PRMT5 extracts. The PRMT5 Direct Activity Assay Kit comes in a convenient format, with a 96-well plate precoated with histone H4 peptide substrate, the antibody against methylated arginine residue of Histone H4, the...
| Schlagworte: | PRMT5, HRMT1L5, |
| Anwendung: | Enzyme kinetics, HTS |
1.358,00 €