Zu "K02516" wurden 58 Artikel gefunden!
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Anti-PRMT5
Artikelnummer: NSJ-RQ5621
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene. It is mapped to 14q11.2. This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the...
| Schlagworte: | Anti-PRMT5, Anti-HRMT1L5, PRMT5 Antibody |
| Anwendung: | WB, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-PRMT5
Artikelnummer: NSJ-RQ7102
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Protein arginine N-methyltransferase 5is an enzyme that in humans is encoded by the PRMT5 gene. It is mapped to 14q11.2. This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the...
| Schlagworte: | Anti-PRMT5, Anti-HRMT1L5, PRMT5 Antibody |
| Anwendung: | WB, IHC (paraffin), Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-PRMT5
Artikelnummer: A300-850A
Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...
| Schlagworte: | Anti-PRMT5, Anti-HRMT1L5 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
PRMT5 (HEK293), active human recombinant protein
Artikelnummer: BPS-51045
Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a FreeStyle 293-F cells.
| Schlagworte: | PRMT5, HRMT1L5, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 73 kD |
876,00 €
PRMT5 (Sf9), active human recombinant protein
Artikelnummer: BPS-51048
Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PRMT5, HRMT1L5, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 73 kD |
759,00 €
Anti-PRMT5
Artikelnummer: A300-849A
Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...
| Schlagworte: | Anti-PRMT5, Anti-HRMT1L5 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
EPZ015666
Artikelnummer: Cay17285-1
Protein arginine methyltransferases (PRMTs) target nuclear and cytoplasmic substrates and can alter protein actions and gene expression. PRMT5, which can methylate histones H2A, H3, and H4, ribonucleoproteins, and other proteins, is upregulated in several human cancers, including lymphomas. Moreover, suppression of...
| Schlagworte: | GSK3235025, N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1616391-65-1 |
| MW: | 383.4 D |
ab 66,00 €
GSK591
Artikelnummer: Cay18354-1
GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric...
| Schlagworte: | EPZ015866, GSK3203591, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide |
| Anwendung: | PRMT5 chemical probe, PRMT5/MEP50 complex inhibitor |
| CAS | 1616391-87-7 |
| MW: | 380.5 D |
ab 43,00 €
LLY-283
Artikelnummer: Cay21596-1
LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 µM. It reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric,...
| Schlagworte: | 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | PRMT5 inhibitor |
| CAS | 2040291-27-6 |
| MW: | 342.4 D |
ab 43,00 €
PRMT5 chemiluminescent assay kit
Artikelnummer: BPS-52002L
The PRMT5 Direct Activity Assay kit is designed to measure PRMT5 activity using purified PRMT5 or PRMT5 extracts. The PRMT5 Direct Activity Assay Kit comes in a convenient format, with a 96-well plate precoated with histone H4 peptide substrate, the antibody against methylated arginine residue of Histone H4, the...
| Schlagworte: | PRMT5, HRMT1L5, |
| Anwendung: | Enzyme kinetics, HTS |
1.267,00 €
HLCL-61 (hydrochloride)
Artikelnummer: Cay19897-1
HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 µM, respectively). It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an...
| Schlagworte: | 9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1158279-20-9 |
| MW: | 380.9 D |
ab 60,00 €
GSK3326595
Artikelnummer: Cay27305-1
GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits methylation of peptides derived from the PRMT5 substrates histone H4 and H2A, SmD3, FUBP1, and HNRNPH1 by the PRMT5/MEP50 complex with IC50 values ranging from 5.9 to 19.7 nM and is more than 4,000-fold selective for PRMT5/MEP50...
| Schlagworte: | 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyrimidinecarboxamide |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1616392-22-3 |
| MW: | 452.6 D |
ab 43,00 €