Zu "K02214" wurden 24 Artikel gefunden!

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XL413 (hydrochloride)
XL413 (hydrochloride)

Artikelnummer: Cay24906-25

XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of...
Schlagworte: 8-chloro-2-(2S)-2-pyrrolidinyl-benzofuro[3,2-d]pyrimidin-4(3H)-one, monohydrochloride
Anwendung: Cdc7 inhibitor
CAS 2062200-97-7
MW: 326.2 D
ab 40,00 €
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PHA-767491 (hydrochloride)
PHA-767491 (hydrochloride)

Artikelnummer: Cay18218-10

Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent...
Schlagworte: CAY10572, 1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one, monohydrochloride
Anwendung: Cdc7 kinase inhibitor
CAS 942425-68-5
MW: 249.7 D
ab 65,00 €
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Anti-CDC7
Anti-CDC7

Artikelnummer: A302-504A

Protein function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. [The UniProt Consortium]
Schlagworte: Anti-CDC7, Anti-CDC7L1, Anti-huCdc7, Anti-HsCdc7, EC=2.7.11.1, Anti-CDC7-related kinase, Anti-Cell division cycle...
Anwendung: WB, IP
Wirt: Rabbit
Spezies-Reaktivität: human
ab 164,00 €
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Anti-CDC7
Anti-CDC7

Artikelnummer: E-AB-16331.120

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple...
Schlagworte: Anti-CDC7, Anti-CDC7L1, Anti-HsCdc7, Anti-huCdc7, EC=2.7.11.1, Anti-CDC7-related kinase, Anti-Cell division cycle...
Anwendung: IHC, ELISA
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
ab 71,00 €
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Anti-CDC7
Anti-CDC7

Artikelnummer: E-AB-13139.120

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple...
Schlagworte: Anti-CDC7, Anti-CDC7L1, Anti-HsCdc7, Anti-huCdc7, EC=2.7.11.1, Anti-CDC7-related kinase, Anti-Cell division cycle...
Anwendung: IHC, ELISA
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
ab 71,00 €
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LY3177833
LY3177833

Artikelnummer: Cay25988-10

LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 µM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of...
Schlagworte: (3R)-3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-1H-isoindol-1-one
Anwendung: Cdc7 kinase inhibitor
CAS 1627696-51-8
MW: 309.3 D
ab 125,00 €
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Anti-CDC7, clone BGF-3
Anti-CDC7, clone BGF-3

Artikelnummer: NSJ-RQ4689

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. This gene encodes Cell division cycle 7-related protein kinase, a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell...
Schlagworte: Anti-huCdc7, Anti-CDC7L1, Anti-HsCdc7, Anti-CDC7-related kinase, Anti-Cell division cycle 7-related protein kinase, CDC7...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human
755,00 €
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Anti-CDC7
Anti-CDC7

Artikelnummer: ARG41364.100

Protein function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. [The UniProt Consortium]
Schlagworte: Anti-CDC7, Anti-CDC7L1, Anti-HsCdc7, Anti-huCdc7, EC=2.7.11.1, Anti-CDC7-related kinase, Anti-Cell division cycle...
Anwendung: FC, WB
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
624,00 €
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CDC7/DBF4 Complex
CDC7/DBF4 Complex

Artikelnummer: BPS-100538

CDC7/DBF4 complex of human CDC7, also known as HsCDC7 and Hsk 1, GenBank Accession No. NM_003503 a.a. 1-574(end) with N-terminal GST-tag and MW= 94 kDa, and human DBF4, also known as ASK and CHIF, GenBank Accession No. NM_006716, a.a. 1-674(end) with N-terminal GST-tag and MW= 125 kDa, co-expressed expressed in an...
Schlagworte: CDC7: HsCDC7, Hsk 1
DBF4: ASK, CHIF,
Anwendung: Enzyme kinetics, inhibitor screening, selectivity profiling
Exprimiert in: insect cells
Ursprungsart: human
MW: 94 / 125 kD
977,00 €
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Anti-CDC7
Anti-CDC7

Artikelnummer: E-AB-18597.120

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple...
Schlagworte: Anti-CDC7, Anti-huCdc7, Anti-HsCdc7, Anti-CDC7L1, EC=2.7.11.1, Anti-CDC7-related kinase, Anti-Cell division cycle...
Anwendung: WB, ELISA
Wirt: Rabbit
Spezies-Reaktivität: human
ab 71,00 €
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Simurosertib
Simurosertib

Artikelnummer: Cay32519-1

Simurosertib is an inhibitor of cell division cycle 7 (Cdc7) kinase (IC50 = 0.26 nM). It is selective for Cdc7 over cyclin-dependent kinase 2 (Cdk2) and Rho-associated kinase 1 (ROCK1, IC50s = 6,300 and 430 nM, respectively). It inhibits phosphorylation of DNA replication licensing factor MCM2 in HeLa cells (IC50 =...
Schlagworte: TAK-931, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-thieno[3,2-d]pyrimidin-4(3H)-one
Anwendung: Cdc7 kinase inhibitor
CAS 1330782-76-7
MW: 341.4 D
ab 60,00 €
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Anti-CDC7
Anti-CDC7

Artikelnummer: G-CAB5738.100

Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human
ab 352,00 €
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