Zu "K02208" wurden 68 Artikel gefunden!
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Anti-Recombinant CDK8, clone A183
Artikelnummer: E-AN301488L.100
Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and...
| Schlagworte: | Anti-CDK8, Anti-Protein kinase K35, Anti-Cyclin-dependent kinase 8, Anti-Mediator complex subunit CDK8, Anti-Cell division... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 304,00 €
BI-1347
Artikelnummer: Cay43667-10
BI-1347 is an inhibitor of Cdk8 and Cdk19 (IC50s = 1. and 1. nM, respectively). It is selective for Cdk8 and Cdk19 over Cdk1, -2, -4, -6, -7, and -9 and a panel of 318 additional kinases at 1 µM. In vivo, BI-1347 (10 mg/kg) reduces tumor volume in an MV4-11 mouse xenograft model. InChI:...
| Schlagworte: | 4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl-1H-pyrazole-1-acetamide |
| Anwendung: | Cdk8 / Cdk19 inhibitor |
| CAS | 2163056-91-3 |
| MW: | 356.43 D |
ab 111,00 €
Anti-CDK8
Artikelnummer: A302-501A
Protein function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is...
| Schlagworte: | Anti-CDK8, EC=2.7.11.22, EC=2.7.11.23, Anti-Protein kinase K35, Anti-Cyclin-dependent kinase 8, Anti-Mediator complex... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-CDK8
Artikelnummer: A302-500A
Protein function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is...
| Schlagworte: | Anti-CDK8, EC=2.7.11.22, EC=2.7.11.23, Anti-Protein kinase K35, Anti-Cyclin-dependent kinase 8, Anti-Mediator complex... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
CCT251545
Artikelnummer: Cay18761-5
CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO...
| Schlagworte: | 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one |
| Anwendung: | CDK8 / CDK19 inhibitor |
| CAS | 1661839-45-7 |
| MW: | 421.9 D |
ab 73,00 €
Senexin B
Artikelnummer: Cay28459-1
Senexin B is an inhibitor of Cdk8 and Cdk19. It inhibits Cdk8 with IC50 values ranging from 24 to 50 nM, depending on the assay used. It selectively inhibits Cdk19 and Cdk8 by 98.6 and 97.8%, respectively, in a panel of greater than 450 kinases at 2 µM but does inhibit MAP4K2 and YSK4 by 69 and 59%, respectively....
| Schlagworte: | SNX2-1-165, 4-[[2-[6-[(4-methyl-1-piperazinyl)carbonyl]-2-naphthalenyl]ethyl]amino]-6-quinazolinecarbonitrile |
| Anwendung: | Cdk8/Cdk19 inhibitor |
| CAS | 1449228-40-3 |
| MW: | 450.5 D |
ab 49,00 €
MSC2530818
Artikelnummer: Cay29669-1
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM). It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3alpha (GSK3alpha, IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an...
| Schlagworte: | [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone |
| Anwendung: | CDK8 inhibitor |
| CAS | 1883423-59-3 |
| MW: | 340.8 D |
ab 110,00 €
Human CDK8 (Cyclin Dependent Kinase 8) ELISA Kit
Artikelnummer: ELK-ELK4302.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CDK8. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CDK8. Next,...
| Schlagworte: | CDK8, EC=2.7.11.22, EC=2.7.11.23, Protein kinase K35, Cyclin-dependent kinase 8, Mediator complex subunit CDK8, Cell... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Anti-CDK19, clone CL14114
Artikelnummer: ATA-AMAb91934.25
Monoclonal Antibody against Human CDK19, Clone ID: CL14114, Gene description: Cyclin dependent kinase 19, Alternative Gene Names: bA346C16.3, CDC2L6, CDK11, KIAA1028, Validated applications: ICC, WB, Uniprot ID: Q9BWU1, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C....
| Anwendung: | ICC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 369,00 €
Anti-CDK19, clone CL14116
Artikelnummer: ATA-AMAb91935.25
Monoclonal Antibody against Human CDK19, Clone ID: CL14116, Gene description: Cyclin dependent kinase 19, Alternative Gene Names: bA346C16.3, CDC2L6, CDK11, KIAA1028, Validated applications: ICC, IHC, WB, Uniprot ID: Q9BWU1, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C....
| Anwendung: | ICC, IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 369,00 €
Human Cdk8 ELISA Kit
Artikelnummer: G-HUFI02304.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-CDK8 (IHC)
Artikelnummer: IHC-00704
Protein function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is...
| Schlagworte: | Anti-CDK8, EC=2.7.11.22, EC=2.7.11.23, Anti-Protein kinase K35, Anti-Cyclin-dependent kinase 8, Anti-Mediator complex... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €