Zu "K02091" wurden 61 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Recombinant CDK6, clone 8D8
Artikelnummer: E-AN301060L.100
Cyclin dependent kinase 6(CDK6) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of...
| Schlagworte: | Anti-CDK6, Anti-Cyclin-dependent kinase 6, Anti-Cell division protein kinase 6, Anti-Serine/threonine-protein kinase... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 258,00 €
BC13
Artikelnummer: Cay42704-1
BC13 is a dual inhibitor of cyclin-dependent kinase 6 (Cdk6) and bromodomain-containing protein 4 (BRD4, IC50s = 36. 234. and 137. nM for Cdk6 and BRD4 bromodomain 1 (BD1) and BD2), respectively). It is selective for Cdk6 over Cdk1-Cdk5 at 500 nM and for BD1 and BD2 in BRD4 over those in BRD2 and BRD3 (IC50s =...
| Schlagworte: | 8-cyclopentyl-2-[2-[4-(3,4-dihydro-5,7-dimethoxy-4-oxo-2-quinazolinyl)benzoyl]-2,7-diazaspiro[3.5]non-7-yl]-5-methyl-pyrid... |
| Anwendung: | Cdk6 / BRD4 dual inhibitor |
| CAS | 3036645-03-8 |
| MW: | 661.76 D |
ab 138,00 €
Abemaciclib
Artikelnummer: LKT-A044176.5
CDK inhibitor
| Schlagworte: | LY2835219,... |
| Anwendung: | CDK inhibitor |
| CAS | 1231929-97-7 |
| MW: | 506.61 D |
ab 136,00 €
LEE-011
Artikelnummer: LKT-L1616.5
CDK4/6 inhibitor.
| Schlagworte: | LEE011, Ribociclib |
| Anwendung: | CDK4/6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434.54 D |
ab 72,00 €
Palbociclib Hydrochloride
Artikelnummer: LKT-P0244.5
Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein...
| Schlagworte: | PD-033291, PD0332991,... |
| Anwendung: | Cdk4 / Cdk6 inhibitor |
| CAS | 827022-32-2 |
| MW: | 484 D |
ab 62,00 €
PD 0332991 (hydrochloride)
Artikelnummer: Cay16273-10
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma...
| Schlagworte: | Palbociclib, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one,... |
| Anwendung: | Cyclin-dependent kinase 4/6 (CDK4/6) inhibitor |
| CAS | 827022-32-2 |
| MW: | 484 D |
ab 56,00 €
Anti-phospho-CDK6 (Tyr24)
Artikelnummer: ARG51830.50
Protein function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in...
| Schlagworte: | Anti-phospho-CDK6, Anti-phospho-CDKN6, EC=2.7.11.22, Anti-phospho-Cyclin-dependent kinase 6, Anti-phospho-Cell division... |
| Anwendung: | WB, IHC (paraffin), ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 471,00 €
Palbociclib
Artikelnummer: LKT-P014442.5
CDK4/6 inhibitor.
| Schlagworte: | PD-0332991, PD0332991 |
| Anwendung: | Cyclin-dependent kinase 4/6 (CDK4/6) inhibitor |
| CAS | 571190-30-2 |
| MW: | 447.54 D |
ab 157,00 €
Anti-CDK6
Artikelnummer: A304-937A
Protein function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in...
| Schlagworte: | Anti-CDK6, Anti-CDKN6, EC=2.7.11.22, Anti-Cyclin-dependent kinase 6, Anti-Cell division protein kinase 6,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
LY2835219
Artikelnummer: Cay21560-1
LY2835219 is an orally bioavailable dual inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when...
| Schlagworte: | N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-... |
| Anwendung: | Antineoplastic, cyclin-dependent kinase (CDK) inhibitor |
| CAS | 1231929-97-7 |
| MW: | 506.6 D |
ab 56,00 €
Palbociclib-d8
Artikelnummer: TGM-T12355-1mg
Description: Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively). Smiles: [2H]C1([2H])NC([2H])([2H])C([2H])([2H])N(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)C1([2H])[2H]. References: Fry DW, et al....
| Schlagworte: | Palbociclib D8, PD 0332991 D8 |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 1628752-83-9 |
| MW: | 455.58 D |
ab 462,00 €
Anti-phospho-CDK6 (Tyr13)
Artikelnummer: ARG51829.100
Protein function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in...
| Schlagworte: | Anti-phospho-CDK6, Anti-phospho-CDKN6, EC=2.7.11.22, Anti-phospho-Cyclin-dependent kinase 6, Anti-phospho-Cell division... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 471,00 €