Zu "K01542" wurden 38 Artikel gefunden!
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Abeprazan
Artikelnummer: Cay45283-1
A potassium-competitive acid blocker, increases TEER and occludin and Muc-1 levels at 20 µg/ml in a Caco-2 cell model of DSS-induced UC, reduces ileal levels of TNF-alpha, IL-6, and IL-1beta in a mouse model of IDM-induced small intestinal injury at 20 mg/kg. SMILES:...
| Schlagworte: | DWP14012, Fexuprazan, 5-(2,4-difluorophenyl)-1-[(3-fluoro phenyl)sulfonyl]-4-methoxy-N-methyl-1H-pyrrole-3-methanamine |
| Anwendung: | Potassium-competitive acid blocker (P-CAB) |
| CAS | 1902954-60-2 |
| MW: | 410.41 D |
ab 88,00 €
Omeprazole
Artikelnummer: Cay14880-100
Omeprazole is an inhibitor of gastric H+/K+ ATPase (IC50 = 1.1 µM for the pig ATPase). It is a racemic mixture of esomeprazole (Cay-17303) and (R)-omeprazole (Cay-18874). Omeprazole (100 µM) decreases zymosan-induced oxygen free radical production in isolated human neutrophils. It is active against 17 strains of H....
| Schlagworte: | OMEP, OMP, OMZ, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole |
| Anwendung: | Gastric H+/K+ ATPase pump inhibitor |
| CAS | 73590-58-6 |
| MW: | 345.4 D |
ab 49,00 €
Pantoprazole
Artikelnummer: Cay21345-1
Pantoprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles with an IC50 value of 6.8 µM. It reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg) and inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat...
| Schlagworte: | BY 1023, SKF 96022, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole |
| Anwendung: | Gastric H+/K+ ATPase pump inhibitor |
| CAS | 102625-70-7 |
| MW: | 383.4 D |
ab 49,00 €
(R)-Omeprazole (sodium salt)
Artikelnummer: Cay18874-1
(R)-Omeprazole is an inhibitor of the gastric H+/K+ ATPase and an enantiomer of esomeprazole (Cay-17303). It inhibits acid secretion induced by histamine (Cay-33828) in isolated rabbit gastric glands (IC50 = 781 µM) to a lesser extent than esomeprazole. (R)-Omeprazole (30 mg/kg) inhibits histamine-induced stomach...
| Schlagworte: | 6-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, monosodium salt |
| Anwendung: | H+/K+ exchanging, alpha / beta polypeptide inhibitor |
| CAS | 161796-77-6 |
| MW: | 368.4 D |
ab 122,00 €
Omeprazole-d3
Artikelnummer: Cay22087-1
Omeprazole-d3 is intended for use as an internal standard for the quantification of omeprazole (Cay-14880) by GC- or LC-MS. Omeprazole is an inhibitor of gastric H+/K+ ATPase (IC50 = 1.1 µM for the pig ATPase). It is a racemic mixture of esomeprazole (Cay-17303) and (R)-omeprazole (Cay-18874). Omeprazole (100 µM)...
| Schlagworte: | OMEP-d3, OMP-d3, OMZ-d3, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-4,5,7-d3 |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 934293-92-2 |
| MW: | 348.4 D |
ab 173,00 €
Vonoprazan (fumarate)
Artikelnummer: Cay24200-500
Vonoprazan is a selective, reversible, and potassium-competitive proton pump inhibitor that inhibits gastric H+/K+ ATPase (IC50 = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 µM. It maintains its inhibitory effect in both weakly acidic (pH 6.5) and neutral (pH 7.5)...
| Schlagworte: | TAK-438, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine, 2-butenedioate |
| Anwendung: | Proton pump inhibitor |
| CAS | 1260141-27-2 |
| MW: | 461.5 D |
ab 67,00 €
Rabeprazole-d4 (sodium salt)
Artikelnummer: Cay26118-500
Rabeprazole-d4 is intended for use as an internal standard for the quantification of rabeprazole (Cay-14939) by GC- or LC-MS. Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than...
| Schlagworte: | 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-4,5,6,7-d4, monosodium salt |
| Anwendung: | GC-MS, LC-MS, internal standard, proton pump inhibitor |
| MW: | 385.4 D |
ab 379,00 €
Rabeprazole
Artikelnummer: LKT-R0105.10
A proton pump/ATP-ase inhibitor.
| Schlagworte: | Rabeprazole Sodium, H+/K+ exchanging, alpha/beta polypeptide inhibitor |
| Anwendung: | Proton pump inhibitor |
| CAS | 117976-89-3 |
| MW: | 359,44 D |
ab 141,00 €
(R)-Lansoprazole
Artikelnummer: Cay18235-10
Lansoprazole (Cay-13627) is a proton pump inhibitor that irreversibly inactivates the H+/K+-stimulated ATPase pumps in parietal cells, inhibiting gastric acid secretion and increasing intragastric pH. It is a 1:1 racemic mixture of (R)-lansoprazole and (S)-lansoprazole, both of which are pharmacologically active....
| Schlagworte: | (+)-Lansoprazole, T-168390, TAK-390,... |
| Anwendung: | Proton pump inhibitor, H+/K+ exchanging polypeptide (ATP4A/B) inhibitor |
| CAS | 138530-94-6 |
| MW: | 369.4 D |
ab 49,00 €
PF-3716556
Artikelnummer: Cay17710-25
PF-3716556 is a potent and selective hydrogen-potassium pump (H+/K+-ATPase) inhibitor in a new class of acid suppressants, the potassium-competitive acid blockers or acid pump antagonists. PF-3716556 inhibited H+/K+-ATPase activity in porcine membrane vesicles, as well as canine and human recombinant cells under...
| Schlagworte: | 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxa... |
| Anwendung: | Hydrogen-potassium pump (H+,K+-ATPase) inhibitor |
| CAS | 928774-43-0 |
| MW: | 394.5 D |
ab 93,00 €
Lansoprazole sulfone
Artikelnummer: Cay22569-10
Lansoprazole sulfone is a phase I metabolite of lansoprazole (Cay-13627, Cay-21967, Cay-18235). Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH. Lansoprazole is metabolized...
| Schlagworte: | AG-1813, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole |
| Anwendung: | Proton pump inhibitor |
| CAS | 131926-99-3 |
| MW: | 385.4 D |
ab 56,00 €
Rabeprazole (sodium salt)
Artikelnummer: Cay14939-10
Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole (Cay-14880), lansoprazole (Cay-13627), and pantoprazole (Cay-21345). Rabeprazole...
| Schlagworte: | E 3810, LY307640, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole, monosodium salt |
| Anwendung: | Proton pump inhibitor |
| CAS | 117976-90-6 |
| MW: | 381.4 D |
ab 49,00 €