Zu "K01201" wurden 65 Artikel gefunden!
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Conduritol B epoxide
Artikelnummer: Cay15216-5
Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid beta-glucosidase, glucosylceramidase, GBA, or GBA1 (IC50 = 9 µM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or...
| Schlagworte: | CBE, 1,2-anhydro-myo-inositol |
| Anwendung: | Irreversible glucocerebrosidase inhibitor |
| CAS | 6090-95-5 |
| MW: | 162.1 D |
ab 74,00 €
Glucosylsphingosine
Artikelnummer: TGM-T78493-1mg
Description: Glucosylsphingosine (lyso-Gb1), a deacylated glucosylceramide derivative metabolized by glucocerebrosidase, serves as a promising, reliable, and specific biomarker for Gaucher disease monitoring [1]. Target: Others. Smiles: CCCCCCCCCC CCC\C=C\[C@@H](O)[C@@H](N)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
| Schlagworte: | Glucopsychosine, Lyso-Gb1 |
| Anwendung: | Cytotoxic compound |
| CAS | 52050-17-6 |
| MW: | 461.63 D |
ab 280,00 €
GBA Protein, Mouse, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-02771-100ug
Description: GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli.
| Schlagworte: | Acid beta-glucosidase, Cholesterol glucosyltransferase, Beta-glucocerebrosidase, Lysosomal glycosylceramidase, Lysosomal... |
| MW: | 71.5 kD |
ab 281,00 €
GBA Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-02772-100ug
Description: GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439.
| Schlagworte: | Cholesteryl-beta-glucosidase, Lysosomal galactosylceramidase, Acid beta-glucosidase, D-glucosyl-N-acylsphingosine... |
| MW: | 57.5 kD |
ab 339,00 €
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Artikelnummer: TGM-TMPH-01623-100ug
Description: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in...
| Schlagworte: | Cholesteryl-beta-glucosidase, Glucosylceramidase beta 1, Imiglucerase, Beta-glucosylceramidase 1, Lysosomal... |
| MW: | 75.6 kD |
ab 198,00 €
GBA Protein, Human, Recombinant
Artikelnummer: TGM-TMPH-01624-100ug
Description: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in...
| Schlagworte: | Cholesterol glucosyltransferase, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Lysosomal... |
| MW: | 55.6 kD |
ab 361,00 €
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-05099-50ug
Description: Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine...
| Schlagworte: | glucosidase, beta, acid, GBA1, GCB, glucosidase, beta, acid, GLUC |
| MW: | 57 kD |
699,00 €
Conduritol B epoxide
Artikelnummer: TGM-TQ0300-100mg
Description: Conduritol B epoxide is an irreversible inhibitor of beta-glucosidase (GCase). Target: Glucosidase. Smiles: O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O. References: Liou B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet....
| Anwendung: | Irreversible glucocerebrosidase inhibitor |
| CAS | 6090-95-5 |
| MW: | 162.14 D |
ab 42,00 €
Afegostat D-Tartrate
Artikelnummer: TGM-T19182-10mg
Description: Afegostat D-Tartrate is a pharmacological chaperone that binds specifically and reversibly with high affinity to acid-beta-glucosidase (GCase) in the endoplasmic reticulum. Target: Others. Smiles: [C@H]([C@@H](C(O)=O)O)(C(O)=O)O.C(O)[C@@H]1[C@@H](O)[C@H](O)CNC1. References: Richter F, et al. A GCase...
| Schlagworte: | D-Isofagomine D-Tartrate, Isofagomine D-Tartrate |
| Anwendung: | Competitive glucosylceramidase (GBA) inhibitor |
| CAS | 957230-65-8 |
| MW: | 297.26 D |
ab 267,00 €
Gcase activator 1
Artikelnummer: TGM-T4280-100mg
Description: Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator. Target: Glucosidase. Smiles: CCCCCO[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2c(C)cc(C)nc12. References: Renato T. Skerlj, et al. Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds. WO...
| Schlagworte: | LTI291, LTI-291, LTI 291 |
| Anwendung: | GCase allosteric activator |
| CAS | 1919820-28-2 |
| MW: | 358.48 D |
ab 42,00 €
Glucosylceramidase (GBA), human, recombinant
Artikelnummer: CSB-YP009289HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 40-536aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: ARPCIPKSFG YSSVVCVCNA TYCDSFDPPT FPALGTFSRY ESTRSGRRME LSMGPIQANH TGTGLLLTLQ PEQKFQKVKG FGGAMTDAAA LNILALSPPA QNLLLKSYFS EEGIGYNIIR...
| Schlagworte: | GC, SGTase, Beta-GC, Alglucerase, Imiglucerase, Lysosomal acid GCase, Acid beta-glucosidase, Beta-glucocerebrosidase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 57.1 kD |
ab 347,00 €
Lysosomal acid Glucosylceramidase (Gbal), mouse, recombinant
Artikelnummer: CSB-YP009289MO.1
Organism: Mus musculus (Mouse). Source: Yeast. Expression Region: 20-515aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: AQPCIPKSFG YSSVVCVCNA SYCDSLDPVT LPALGTFSRY ESTRRGRRME LSVGAIQANR TGTGLLLTLQ PEKKFQKVKG FGGAMTDATA LNILALSPPT QKLLLRSYFS TNGIEYNIIR...
| Schlagworte: | SGTase, Lysosomal acid GCase, Acid beta-glucosidase, Beta-glucocerebrosidase, Cholesteryl-beta-glucosidase, Cholesterol... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | mouse |
| MW: | 57.5 kD |
ab 347,00 €