Zu "K01201" wurden 76 Artikel gefunden!
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GBA Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-02772-10ug
Description: GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439.
| Schlagworte: | Lysosomal cholesterol glycosyltransferase , D-glucosyl-N-acylsphingosine glucohydrolase , Gba , Acid beta-glucosidase ,... |
| MW: | 57.5 kD |
ab 118,00 €
GCase Activator 3
Artikelnummer: Cay45307-1
An activator of GCase (AC50 = 1.49 µM), increases GCase protein levels and activity and reduces mutant GCase protein misfolding in GBA1N370S/84GG-expressing patient-derived fibroblasts from patients with Gaucher disease, increases GCase protein levels and activity in iPSC-derived and GBA1N370S-expressing iPSCs...
| Schlagworte: | beta-Glucocerebrosidase Activator 3,... |
| Anwendung: | Lysosomal acid glucosylceramidase (Gcase) activator |
| CAS | 2270984-21-7 |
| MW: | 384.44 D |
ab 444,00 €
Anti-Recombinant GBA, clone A678
Artikelnummer: E-AN301962L.100
Beta-Glucosylceramidase (beta-GC) is a lysosomal enzyme that catalyzes the hydrolysis of glucocerebroside into free ceramide and glucose. Lysosomal breakdown of glucocerebroside is required for cellular metabolism of complex lipids and proper turnover of cellular membrane. In the absence of GBA, the gene that...
| Schlagworte: | Anti-GBA1, Anti-Alglucerase, Anti-Imiglucerase, Anti-Acid beta-glucosidase, Anti-Beta-glucocerebrosidase,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Conduritol B epoxide
Artikelnummer: Cay15216-5
Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid beta-glucosidase, glucosylceramidase, GBA, or GBA1 (IC50 = 9 µM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or...
| Schlagworte: | CBE, 1,2-anhydro-myo-inositol |
| Anwendung: | Irreversible glucocerebrosidase inhibitor |
| CAS | 6090-95-5 |
| MW: | 162.1 D |
ab 84,00 €
NCGC607
Artikelnummer: Cay21923-1
NCGC607 is a salicylic acid derivative and small molecule glucocerebrosidase (GCase) chaperone. A mutation in the GCase gene is found in patients with Gaucher disease and is the most common genetic risk factor for Parkinson's disease. In induced pluripotent stem cell-derived (iPSC) macrophages from patients with...
| Schlagworte: | 2-[2-[(4-iodophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-benzamide |
| Anwendung: | Glucocerebrosidase activator |
| CAS | 1462267-07-7 |
| MW: | 543.4 D |
ab 97,00 €
Isofagomine (D-tartrate)
Artikelnummer: Cay16137-5
Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal beta-glucosidase (Ki = 0.016-0.025 µM, IC50 = 0.06 µM). By interacting with the catalytic pocket of beta-glucosidase it acts as a chemical chaperone that increases the amount of beta-glucosidase by stabilizing and/or promoting the folding of the...
| Schlagworte: | 5R-(hydroxymethyl)-3R,4R-piperidinediol, mono 2S,3S-dihydroxybutanedioate |
| Anwendung: | Competitive glucosylceramidase (GBA) inhibitor |
| CAS | 957230-65-8 |
| MW: | 297.3 D |
ab 137,00 €
1-beta-D-Glucosylsphingosine (d18:1)
Artikelnummer: Cay23211-1
1-beta-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides (Cay-23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of...
| Schlagworte: | 1-beta-D-Glucosylsphingosine (synthetic), Glucosyl-C18-Sphingosine, Glucosylsphingosine (d18:1),... |
| Anwendung: | Cytotoxic compound |
| CAS | 52050-17-6 |
| MW: | 461.6 D |
ab 160,00 €
LTI-291
Artikelnummer: Cay34305-5
LTI-291 is a CNS-penetrant allosteric activator of glucocerebrosidase (GCase). It increases the activity of wild-type human GCase by 25 and 130% when used at concentrations of 0.1 and 1 µM, respectively.Formal Name: 5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide. CAS Number:...
| Schlagworte: | 5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| Anwendung: | GCase allosteric activator |
| CAS | 1919820-28-2 |
| MW: | 358.5 D |
ab 153,00 €
Human Glucosylceramidase / GBA ELISA Kit
Artikelnummer: G-HUFI01329.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Mouse Glucosylceramidase / GBA ELISA Kit
Artikelnummer: G-MOFI00426.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Anti-GBA / Lysosomal acid glucosylceramidase, clone AACA-7
Artikelnummer: NSJ-RQ5035
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. [RefSeq] Protein function: Glucosylceramidase that catalyzes, within the lysosomal...
| Schlagworte: | Anti-GBA, Anti-SGTase, Anti-Beta-GC, Anti-Alglucerase, Anti-Imiglucerase, Anti-Lysosomal acid GCase, Anti-Acid... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-GBA
Artikelnummer: ARG58696.100
Protein function: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes...
| Schlagworte: | Anti-GC, Anti-SGTase, Anti-Beta-GC, Anti-Alglucerase, Anti-Imiglucerase, Anti-Lysosomal acid GCase, Anti-Acid... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
658,00 €