Zu "K00801" wurden 45 Artikel gefunden!
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YM-53601
Artikelnummer: Cay18113-500
YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively). It inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg). YM-53601 dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets....
| Schlagworte: | 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride |
| Anwendung: | Squalene synthase inhibitor |
| CAS | 182959-33-7 |
| MW: | 372.9 D |
ab 272,00 €
FDFT1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-02137-100ug
Description: FDFT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 52.0 kDa and the accession number is P37268.
| Schlagworte: | FPP:FPP farnesyltransferase, Squalene synthase, Farnesyl-diphosphate farnesyltransferase, FDFT1, Farnesyl-diphosphate... |
| MW: | 52.0 kD |
ab 198,00 €
Lapaquistat acetate
Artikelnummer: TGM-T15709-100mg
Description: Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Target:...
| Schlagworte: | TAK-475 |
| Anwendung: | Targets farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21] (FDFT1) |
| CAS | 189060-13-7 |
| MW: | 645.14 D |
ab 3.824,00 €
YM-53601
Artikelnummer: TGM-T26345-1mg
Description: YM-53601 is a squalene synthase activity inhibitor that acts by lowering cholesterol as well as triglycerides. Target: Others. Smiles: Cl.F\C(COc1ccc2c(c1)[nH]c1ccccc21)=C1\CN2CCC1CC2. References: Alarcon VB, Marikawa Y. Statins inhibit blastocyst formation by preventing geranylgeranylation. Mol Hum...
| Schlagworte: | YM53601 |
| Anwendung: | Squalene synthase inhibitor |
| CAS | 182959-33-7 |
| MW: | 372.86 D |
161,00 €
Squalene
Artikelnummer: TGM-T4749-100mg
Description: Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All higher organisms produce squalene, including humans. Squalene is an intermediate...
| Schlagworte: | trans-Squalene, Spinacene, all-trans-Squalene, AddaVax, Super Squalene, Nikko Squalane EX |
| Anwendung: | Biosynthetic steroid precursor |
| CAS | 111-02-4 |
| MW: | 410.72 D |
ab 31,00 €
Zaragozic Acid A
Artikelnummer: Cay17452-1
Squalene synthase catalyzes the first committed step in cholesterol synthesis, mediating the reductive dimerization of farnesyl pyrophosphate (Cay-63250) to produce squalene. Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase (Ki = 78 pM in vitro). It...
| Schlagworte: | L-694,599, Squalestatin S1, (7S)-11-acetate... |
| Anwendung: | Reversible competitive squalene synthase inhibitor |
| CAS | 142561-96-4 |
| MW: | 690.7 D |
ab 266,00 €
Squalene synthase (FDFT1), partial, human, recombinant
Artikelnummer: CSB-EP008562HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2-417aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: EFVKCLGHPE EFYNLVRFRI GGKRKVMPKM DQDSLSSSLK TCYKYLNQTS RSFAAVIQAL DGEMRNAVCI FYLVLRALDT LEDDMTISVE KKVPLLHNFH SFLYQPDWRF MESKEKDRQV LEDFPTISLE FRNLAEKYQT...
| Schlagworte: | SS, SQS, FDFT1, Squalene synthase, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 52 kD |
ab 219,00 €
Mouse Somatostatin ELISA Kit
Artikelnummer: G-MOFI00257.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
694,00 €
Squalene
Artikelnummer: Cay27058-50
Squalene is a biosynthetic precursor to all steroids and a terpene originally isolated from shark liver oil. Squalene is produced in mammals by condensation of two farnesyl diphosphate molecules by squalene synthase and then oxidized to squalene epoxide for use in the biosynthesis of lanosterol (Cay-19521),...
| Schlagworte: | trans-Squalene, Spinacene, (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene |
| Anwendung: | Biosynthetic steroid precursor |
| CAS | 111-02-4 |
| MW: | 410.7 D |
ab 44,00 €
Anti-FDFT1
Artikelnummer: ARG55581.100
| Schlagworte: | Anti-SS, Anti-SQS, Anti-FDFT1, EC=2.5.1.21, Anti-Squalene synthase, Anti-FPP:FPP farnesyltransferase,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
Anti-FDFT1
Artikelnummer: ARG65709.100
| Schlagworte: | Anti-SS, Anti-SQS, Anti-FDFT1, EC=2.5.1.21, Anti-Squalene synthase, Anti-FPP:FPP farnesyltransferase,... |
| Anwendung: | WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
658,00 €
Anti-FDFT1
Artikelnummer: A305-361A
| Schlagworte: | Anti-SS, Anti-SQS, Anti-FDFT1, EC=2.5.1.21, Anti-Squalene synthase, Anti-FPP:FPP farnesyltransferase,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €