Zu "K00787" wurden 62 Artikel gefunden!
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FDPS, His, Human
Artikelnummer: GSC-Z05286-100
Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders...
| Schlagworte: | FDPS, Geranyltranstransferase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyl pyrophosphate... |
| Ursprungsart: | human |
| MW: | 41.93 kD |
ab 497,00 €
Anti-FDPS/Farnesyl Diphosphate Synthase Monoclonal...
Artikelnummer: E-AN300076P.100
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein...
| Schlagworte: | FPS, FPP synthase, Geranyltranstransferase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyl... |
| Anwendung: | WB, FCM, ICC/IF, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Zoledronic Acid (hydrate)
Artikelnummer: Cay14984-25
Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It has a high affinity for hydroxyapatite (Ki = 3.47 µM) and binds directly to mineralized bone where it...
| Schlagworte: | P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid, monohydrate |
| Anwendung: | GTPase prenylation inhibitor, farnesylpyrophosphate synthetase inhibitor |
| CAS | 165800-06-6 |
| MW: | 290.1 D |
ab 102,00 €
Zoledronic Acid Hydrate
Artikelnummer: LKT-Z5744.10
Bisphosphonate, FPPS inhibitor.
| Schlagworte: | Zoledronate, Zometa, [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]- bisphosphonic acid |
| Anwendung: | Farnesylpyrophosphate synthetase inhibitor |
| CAS | 165800-06-6 |
| MW: | 290.1 D |
ab 128,00 €
Pamidronate (sodium salt)
Artikelnummer: Cay23699-25
Pamidronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively). In rats, it inhibits bone resorption when used at doses of 16 µmol/kg per day, impairs long bone growth at >40 µmol/kg per day, and...
| Schlagworte: | APD, CGP 23339A, Pamidronic Acid, P,P'-(3-amino-1-hydroxypropylidene)bis-phosphonic acid, disodium salt |
| Anwendung: | Farnesylpyrophosphate synthetase inhibitor |
| CAS | 57248-88-1 |
| MW: | 279 D |
ab 75,00 €
Ibandronate (sodium hydrate)
Artikelnummer: Cay21361-25
Ibandronate is a bisphosphonate that has been used in formulations for the treatment of osteoporosis. It binds to hydroxyapatite crystals with an affinity constant of 2.36 µM, inhibiting their growth and bone resorption.Formal Name: P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-phosphonic acid, monosodium...
| Schlagworte: | P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-phosphonic acid, monosodium salt, monohydrate |
| Anwendung: | Bisphosphonate, osteoporosis agent, FDPS inhibitor |
| CAS | 138926-19-9 |
| MW: | 359.2 D |
ab 60,00 €
Risedronate sodium hydrate
Artikelnummer: LKT-R3373.100
A pyridinyl biphosphate which inhibits osteoclast-mediated bone resorption.
| Schlagworte: | bone resorption inhibitor |
| Anwendung: | Calcium regulating agent, Farnesylpyrophosphate synthetase inhibitor |
| CAS | 115436-72-1 |
| MW: | 350,13 D |
ab 100,00 €
Alendronate sodium hydrate
Artikelnummer: TGM-T6373-50mg
Description: Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis. Target: Transferase. Smiles: C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.[Na+].O.O. References: Fisher JE, et al. Proc...
| Schlagworte: | G-704650 Adronat, Fosamax, G-704650, Alendronate, MK 217, Alendronate sodium trihydrate |
| Anwendung: | Targets farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10] (FDPS) |
| CAS | 121268-17-5 |
| MW: | 325.12 D |
ab 39,00 €
Anti-FDPS
Artikelnummer: A305-045A
Protein function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation....
| Schlagworte: | Anti-FPS, Anti-FDPS, EC=2.5.1.1, EC=2.5.1.10, Anti-FPP synthase, Anti-Geranyltranstransferase,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Zoledronate Disodium
Artikelnummer: LKT-Z5645.10
Zoledronic acid is used as an antiresorptive agent in bone.
| Schlagworte: | Zoledronic acid disodium salt tetrahydrate |
| Anwendung: | Farnesylpyrophosphate synthetase inhibitor |
| CAS | 165800-07-7 |
| MW: | 390,13 D |
ab 179,00 €
Ibandronate Sodium Monohydrate
Artikelnummer: LKT-I0502.10
Bisphosphonate.
| Schlagworte: | Ibandronic acid sodium salt, [1-Hydroxy-3-(methylpentylamino)propylidene]bis- phosphonic acid |
| Anwendung: | Farnesylpyrophosphate synthetase inhibitor |
| CAS | 138926-19-9 |
| MW: | 359.21 D |
ab 177,00 €
Risedronic Acid
Artikelnummer: LKT-R3374.100
Bisphosphonate, inhibits transfer of farnesyl pyrophosphate.
| Schlagworte: | Risedronate, [1-Hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid |
| Anwendung: | Bisphosphonate, Farnesylpyrophosphate synthetase inhibitor |
| CAS | 105462-24-6 |
| MW: | 283,11 D |
ab 85,00 €