Zu "K00720" wurden 24 Artikel gefunden!
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DL-threo-PPMP (hydrochloride)
Artikelnummer: Cay17236-5
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin...
| Schlagworte: | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol,... |
| Anwendung: | Glucosylceramide synthase inhibitor |
| CAS | 139974-41-7 |
| MW: | 511.2 D |
ab 54,00 €
Human UGCG (UDP Glucose Ceramide Glucosyltransferase)...
Artikelnummer: ELK-ELK5132.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human UGCG. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human UGCG. Next,...
| Schlagworte: | GCS, GLCT-1, Glucosylceramide synthase, Glycosylceramide synthase, Ceramide glucosyltransferase, UDP-glucose ceramide... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 303,00 €
N-Butyldeoxynojirimycin (hydrochloride)
Artikelnummer: Cay21065-1
NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and beta-glucosidase 2 (IC50s = 32 and 81 µM, respectively, for the rat recombinant enzymes). It also increases the activity of wild-type acid beta-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells...
| Schlagworte: | Miglustat, NB-DNJ, 1-butyl-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride |
| Anwendung: | Glucosylceramide synthase inhibitor |
| CAS | 210110-90-0 |
| MW: | 255.7 D |
ab 50,00 €
Eliglustat (hemitartrate)
Artikelnummer: Cay21487-10
Eliglustat is an inhibitor of glucosylceramide synthase (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells). It is selective for glucosylceramide synthase over alpha-glucosidase I and II, alpha-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and...
| Schlagworte: | Genz-112638, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide,... |
| Anwendung: | Glucosylceramide synthase inhibitor |
| CAS | 928659-70-5 |
| MW: | 479.6 D |
ab 43,00 €
AMP-Deoxynojirimycin
Artikelnummer: Cay10010332-1
The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as beta-glucosidase 2 (BGD), cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into...
| Schlagworte: | Adamantane-pentyl-dNM, AMP-dNM, N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin,... |
| Anwendung: | Glucosylceramide synthase inhibitor |
| CAS | 216758-20-2 |
| MW: | 397.6 D |
ab 58,00 €
Ibiglustat
Artikelnummer: Cay32878-250
Ibiglustat is an inhibitor of glucosylceramide (GlcCer) synthase. Dietary administration of ibiglustat (0.03% w/w) reduces globotriaosylceramide (Gb3) and lyso-Gb3 accumulation in a variety of tissues, including the kidney, heart, and brain, in the Gla-/- mouse model of Fabry disease. It reduces the latency to paw...
| Schlagworte: | Genz-682452, GZ/SAR402671, Venglustat, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-carbamic acid,... |
| Anwendung: | GlcCer synthase (ceramide glucosyltransferase) inhibitor |
| CAS | 1401090-53-6 |
| MW: | 389.5 D |
ab 172,00 €
(+)-D-threo-PDMP (hydrochloride)
Artikelnummer: Cay10178-10
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Cay-62595). (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 µM in an enzyme assay. (+)-D-threo-PDMP is the active component of...
| Schlagworte: | D-PDMP, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride |
| Anwendung: | Glucosylceramide (GlyCer) synthetase inhibitor |
| CAS | 139889-62-6 |
| MW: | 427 D |
628,00 €
Glucosylceramide (bovine buttermilk)
Artikelnummer: Cay23206-500
Glucosylceramides are formed by the tethering of glucose to a ceramide by glucosylceramides synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in...
| Schlagworte: | GluCers (buttermilk), Glucocerebrosides (buttermilk) |
| MW: | 784.2 D |
ab 85,00 €
Glucosylceramide (plant)
Artikelnummer: Cay25850-10
Glucosylceramides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in...
| Schlagworte: | GluCers (soy) |
| Anwendung: | Glucocerebroside mixture |
| CAS | 497155-61-0 |
| MW: | 714 D |
ab 149,00 €
Genz-123346
Artikelnummer: Cay28500-100
Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM). It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day. Genz-123346 (125...
| Schlagworte: | N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-nonanamide |
| Anwendung: | Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor |
| CAS | 491833-30-8 |
| MW: | 418.6 D |
ab 175,00 €
Human UGCG ELISA Kit
Artikelnummer: G-HUFI01598.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Anti-UGCG
Artikelnummer: E-AB-14100.120
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in...
| Schlagworte: | Anti-GCS, Anti-UGCG, Anti-GLCT-1, EC=2.4.1.80, Anti-Glucosylceramide synthase, Anti-Ceramide glucosyltransferase,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €