Zu "K00512" wurden 71 Artikel gefunden!
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NEU
Anti-Recombinant Cytochrome P450 17A1/CYP17A1, clone C112741
Artikelnummer: E-AN303121L.100
Protein function: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:22266943, PubMed:25301938, PubMed:27339894, PubMed:9452426). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis,...
| Schlagworte: | Anti-CYP17A1, Anti-CYPXVII, Anti-Cytochrome P450-C17, Anti-Cytochrome P450 17A1, Anti-Steroid 17-alpha-monooxygenase,... |
| Anwendung: | WB, IHC, ICC/IF, FCM, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
NEU
Anti-Recombinant CYP17A1, clone C112056
Artikelnummer: E-AN302436L.100
Protein function: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:22266943, PubMed:25301938, PubMed:27339894, PubMed:9452426). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis,...
| Schlagworte: | Anti-CYP17A1, Anti-CYPXVII, Anti-Cytochrome P450-C17, Anti-Cytochrome P450 17A1, Anti-Steroid 17-alpha-monooxygenase,... |
| Anwendung: | WB, IHC, IF, IP, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1),...
Artikelnummer: CSB-EP006392HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: AKKT+24-508aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: AKKTGAKYPK SLLSLPLVGS LPFLPRHGHM HNNFFKLQKK YGPIYSVRMG TKTTVIVGHH QLAKEVLIKK GKDFSGRPQM ATLDIASNNR KGIAFADSGA HWQLHRRLAM ATFALFKDGD QKLEKIICQE...
| Schlagworte: | CYP17, CYPXVII, Cytochrome P450c17, Cytochrome P450-C17, Cytochrome P450 17A1, Steroid 17-alpha-monooxygenase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 58.6 kD |
ab 219,00 €
Abiraterone Acetate
Artikelnummer: Cay15148-5
Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17alpha-hydroxylase activities, respectively). It is also a prodrug form of abiraterone (Cay-9002768). Abiraterone acetate reduces plasma testosterone levels, increases plasma...
| Schlagworte: | CB-7630, (3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol, acetate ester |
| Anwendung: | CYP17A1 blocking |
| CAS | 154229-18-2 |
| MW: | 391.6 D |
ab 187,00 €
Abiraterone
Artikelnummer: Cay9002768-1
Abiraterone is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 0.0029 and 0.004 µM for the 17,20-lyase and 17alpha-hydroxylase activities, respectively) and active metabolite of abiraterone acetate (Cay-15148). It is formed from abiraterone acetate by arylacetamide deacetylase. Abiraterone is...
| Schlagworte: | CB-7598, (3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol |
| Anwendung: | CYP17A1 inhibitor |
| CAS | 154229-19-3 |
| MW: | 349.5 D |
ab 51,00 €
17alpha-hydroxy Pregnenolone
Artikelnummer: Cay29181-100
17alpha-hydroxy Pregnenolone is a metabolite of pregnenolone (Cay-19864) and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA, Cay-15728). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated...
| Schlagworte: | 17-alpha-OH Pregnenolone, NSC 63853, 3beta,17-dihydroxy-pregn-5-en-20-one |
| Anwendung: | Pregnenolone metabolite, DHEA precursor |
| CAS | 387-79-1 |
| MW: | 332.5 D |
ab 69,00 €
Galeterone
Artikelnummer: Cay17586-25
The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17alpha-hydroxylase/17,20 lyase because it catalyzes both 17alpha-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC50 = 300...
| Schlagworte: | TOK-001, 17-(1H-benzimidazol-1-yl)-androsta-5,16-dien-3beta-ol |
| Anwendung: | CYP17 inhibitor |
| CAS | 851983-85-2 |
| MW: | 388.6 D |
ab 40,00 €
Abiraterone
Artikelnummer: LKT-A0534.5
A selective steroidal inhibitor of cytochrome P450 (17) alpha (17 alpha-hydroxylase/C17-20 lyase) is highly active in the treatment of castration-resistant prostate cancer.
| CAS | 154229-19-3 |
| MW: | 349.51 D |
ab 125,00 €
Anti-Cytochrome P450 17A1, clone 6E1-H9-F6
Artikelnummer: ARG54107.100
Protein function: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. [The...
| Schlagworte: | Anti-CYP17, Anti-CYP17A1, Anti-CYPXVII, EC=4.1.2.30, EC=1.14.99.9, Anti-Cytochrome P450c17, Anti-Cytochrome P450-C17,... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
658,00 €
Anti-CYP17A1, Internal
Artikelnummer: ARG63933.100
Protein function: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. [The...
| Schlagworte: | Anti-CYP17, Anti-CYP17A1, Anti-CYPXVII, EC=4.1.2.30, EC=1.14.99.9, Anti-Cytochrome P450c17, Anti-Cytochrome P450-C17,... |
| Anwendung: | ELISA, IHC (paraffin), WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Anti-CYP17A1
Artikelnummer: NSJ-R34717-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cytochrome P450, family 17, subfamily A, polypeptide 1 Protein function: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to...
| Schlagworte: | Anti-CYP17, Anti-CYP17A1, Anti-CYPXVII, Anti-Cytochrome P450c17, Anti-Cytochrome P450-C17, Anti-Cytochrome P450 17A1,... |
| Anwendung: | WB, IHC, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Abiraterone Acetate-d4
Artikelnummer: Cay22096-1
Abiraterone acetate-d4 is intended for use as an internal standard for the quantification of abiraterone acetate (Cay-15148) by GC- or LC-MS. Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17alpha-hydroxylase activities,...
| Schlagworte: | CB-7630-d4, (3beta)-17-(3-pyridinyl-d4)-androsta-5,16-dien-3-ol, acetate ester |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 2122245-63-8 |
| MW: | 395.6 D |
ab 144,00 €