Zu "K00507" wurden 80 Artikel gefunden!
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Anti-SCD1 / Stearoyl-CoA desaturase
Artikelnummer: NSJ-RQ8778
0.5mg/ml if reconstituted with 0.2ml sterile DI water. This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately...
| Schlagworte: | Anti-SCD, Anti-Acyl-CoA desaturase, Anti-Delta(9)-desaturase, Anti-Fatty acid desaturase, Anti-Stearoyl-CoA desaturase,... |
| Anwendung: | WB, IHC (paraffin), FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-SCD1 / Stearoyl-CoA desaturase
Artikelnummer: NSJ-FY12521
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SCD1 antibody detects Stearoyl-CoA desaturase, an endoplasmic reticulum enzyme that catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, primarily oleate and palmitoleate. This reaction is essential for...
| Schlagworte: | Anti-SCD, Anti-Acyl-CoA desaturase, Anti-Delta(9)-desaturase, Anti-Fatty acid desaturase, Anti-Stearoyl-CoA desaturase,... |
| Anwendung: | ELISA, FC, IP, IF, ICC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
CAY10566
Artikelnummer: Cay10012562-1
Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for...
| Schlagworte: | 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine |
| Anwendung: | SCD inhibitor |
| CAS | 944808-88-2 |
| MW: | 389.8 D |
ab 85,00 €
A-939572
Artikelnummer: Cay19123-50
A-939572 inhibits stearoyl-CoA desaturase 1 (IC50 = 6.3 nM), a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs). This compound has been used to induce cell death of hPSCs as well as to inhibit the proliferation of human non-small cell lung carcinoma H1299 cells in...
| Schlagworte: | SCD1 Inhibitor, Stearoyl-CoA Desaturase 1 Inhibitor,... |
| Anwendung: | Stearoyl-CoA desaturase 1 inhibitor |
| CAS | 1032229-33-6 |
| MW: | 387.9 D |
ab 83,00 €
Sterculic Acid
Artikelnummer: Cay26735-25
Sterculic acid is a cyclopropene fatty acid that has been found in S. foetida. It is an inhibitor of Delta9-desaturase that decreases 9(Z)-myristoleic acid (Cay-9002461) and increases oleic acid (Cay-90260) and 9(Z),11(E)-conjugated linoleic acid (Cay-90140) levels in the milk of lactating ewes when administered at...
| Schlagworte: | 2-octyl-1-cyclopropene-1-octanoic acid |
| Anwendung: | Cyclopropene fatty acid |
| CAS | 738-87-4 |
| MW: | 294.5 D |
588,00 €
MF438
Artikelnummer: Cay33349-5
MF438 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1, IC50 = 2.3 nM for the rat enzyme), an enzyme that catalyzes the formation of a cis double bond at the ?9 position of stearoyl-CoA to produce oleoyl-CoA. It reduces spheroid formation in NCI H460 and patient-derived non-small cell lung cancer (NSCLC) cells in...
| Schlagworte: | 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-pyridazine |
| Anwendung: | Stearoyl-CoA desaturase inhibitor |
| CAS | 921605-87-0 |
| MW: | 421.4 D |
ab 49,00 €
MK-8245
Artikelnummer: Cay29421-10
MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD, IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Delta5- and Delta6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to...
| Schlagworte: | 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid |
| Anwendung: | Stearoyl-CoA desaturase inhibitor |
| CAS | 1030612-90-8 |
| MW: | 467.3 D |
ab 102,00 €
Anti-SCD/SCD1/Stearoyl-CoA Desaturase
Artikelnummer: A305-259A-T
Protein function: Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates...
| Schlagworte: | Anti-SCD, Anti-hSCD1, Anti-Delta-9 desaturase, Anti-Acyl-CoA desaturase, Anti-Delta(9)-desaturase, Anti-Fatty acid... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
SW203668 (trifluoroacetate salt)
Artikelnummer: Cay19379-10
SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and...
| Schlagworte: | 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide, trifluoroacetate salt |
| Anwendung: | Stearoyl-CoA desaturase inhibitor prodrug |
| CAS | 2117405-48-6 |
| MW: | 503.5 D |
ab 56,00 €
PluriSln 1
Artikelnummer: Cay16161-5
PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs). PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing...
| Schlagworte: | N'-phenyl-hydrazine-Isonicotinic acid, NSC 14613, 2-phenylhydrazide-4-pyridinecarboxylic acid |
| Anwendung: | Stearoyl-CoA desaturase inhibitor, hPSC apoptosis inducer |
| CAS | 91396-88-2 |
| MW: | 213.2 D |
ab 93,00 €
CAY10566
Artikelnummer: TGM-T14878-1mg
Description: CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of...
| Anwendung: | SCD inhibitor |
| CAS | 944808-88-2 |
| MW: | 389.81 D |
ab 41,00 €
A939572
Artikelnummer: TGM-T4515-1mg
Description: A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1. Target: Stearoyl-CoA Desaturase (SCD), Dehydrogenase. Smiles: CNC(=O)c1cccc(NC(=O)N2CCC(CC2)Oc2ccccc2Cl)c1. References: Xin Z, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA...
| Anwendung: | Stearoyl-CoA desaturase 1 inhibitor |
| CAS | 1032229-33-6 |
| MW: | 387.86 D |
ab 30,00 €