Zu "K00507" wurden 72 Artikel gefunden!
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CAY10566
Artikelnummer: Cay10012562-1
Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for...
| Schlagworte: | 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine |
| Anwendung: | SCD inhibitor |
| CAS | 944808-88-2 |
| MW: | 389.8 D |
ab 96,00 €
Sterculic Acid methyl ester
Artikelnummer: TGM-T85147-10mg
Description: Sterculic acid methyl ester, an ester derivative of sterculic acid known for inhibiting Delta9 desaturase, has been found to adversely affect and exhibit toxicity towards R. opacus bacteria at a concentration of 0.75 mM. It not only hampers bacterial growth but also modifies fatty acid composition by...
| Schlagworte: | SFE 20:2, Methyl Sterculate |
| Anwendung: | Cyclopropene fatty acid methyl ester |
| CAS | 3220-60-8 |
| MW: | 308.5 D |
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SCD1 Protein, Mouse, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-02491-100ug
Description: SCD1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.4 kDa and the accession number is P13516.
| Schlagworte: | Scd1, Delta(9)-desaturase 1, Fatty acid desaturase 1, Acyl-CoA desaturase 1, Stearoyl-CoA desaturase 1 |
| MW: | 18.4 kD |
ab 281,00 €
PluriSIn 1
Artikelnummer: TGM-T1869-100mg
Description: PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, highlighting a unique role for lipid metabolism in hPSCs. Target: Apoptosis, Dehydrogenase, Stearoyl-CoA Desaturase (SCD). Smiles: O=C(NNC1=CC=CC=C1)C1=CC=NC=C1. References: Ben-David...
| Schlagworte: | PluriSln 1, NSC 14613, PluriSIn #1 |
| Anwendung: | Stearoyl-CoA desaturase inhibitor, hPSC apoptosis inducer |
| CAS | 91396-88-2 |
| MW: | 213.24 D |
ab 31,00 €
CVT-12012
Artikelnummer: TGM-T6412-100mg
Description: CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD, IC50 = 6.1 nM in HepG2 cells). Target: Stearoyl-CoA Desaturase (SCD). Smiles: Cc1nc2ccc(NCc3cccc(c3)C(F)(F)F)cc2n(CCNC(=O)CO)c1=O. References: Koltun D O , Vasilevich N I , Parkhill E Q , et al. Orally bioavailable,...
| Anwendung: | Stearoyl-coA desaturase (SCD) inhibitor. |
| CAS | 1018675-35-8 |
| MW: | 434.41 D |
ab 34,00 €
CAY10566
Artikelnummer: TGM-T14878-1mg
Description: CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of...
| Anwendung: | SCD inhibitor |
| CAS | 944808-88-2 |
| MW: | 389.81 D |
ab 46,00 €
SCD1 inhibitor-1
Artikelnummer: TGM-T12863-100mg
Description: SCD1 inhibitor-1 is a potent, liver-selective inhibitor of stearoyl-CoA desaturase-1 (SCD1). Target: Others. Smiles: [Na].CCCCc1ccccc1NCc1ccc(s1)C(=O)Nc1nc(CC(O)=O)cs1. References: Iida T, et al. Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid...
| Anwendung: | Stearoyl-CoA desaturase (SCD) inhibitor |
| CAS | 1069094-65-0 |
| MW: | 452.54 D |
ab 376,00 €
MF-438
Artikelnummer: TGM-T16068-100mg
Description: MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD). Smiles: Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
| Anwendung: | Stearoyl-CoA desaturase inhibitor |
| CAS | 921605-87-0 |
| MW: | 421.44 D |
ab 98,00 €
SW203668 (trifluoroacetate salt)
Artikelnummer: TGM-T35675-10mg
Description: SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM,...
| Anwendung: | Stearoyl-CoA desaturase inhibitor prodrug |
| CAS | 2117405-48-6 |
| MW: | 503.49 D |
ab 93,00 €
MK-8245
Artikelnummer: TGM-T2650-1mg
Description: MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function. Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD). Smiles: OC(=O)Cn1nnc(n1)-c1cc(no1)N1CCC(CC1)Oc1cc(F)ccc1Br. References: Oballa RM, et al....
| Anwendung: | Stearoyl-CoA desaturase inhibitor |
| CAS | 1030612-90-8 |
| MW: | 467.25 D |
ab 34,00 €
SCD1 inhibitor-3
Artikelnummer: TGM-T38683-100mg
Description: SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety. SCD1 inhibitor-3 demonstrates strong potential for research in metabolic diseases, including obesity, type II diabetes, and dyslipidemia, as well as various skin conditions like acne...
| Schlagworte: | SCD1 inhibitor 17a, SCD1 inhibitor-3, SCD1-IN-3 |
| Anwendung: | Stearoyl-CoA desaturase (SCD) inhibitor |
| CAS | 1282606-48-7 |
| MW: | 393.37 D |
ab 83,00 €
Sterculic acid
Artikelnummer: TGM-T41253-25mg
Description: Sterculic acid, a stearoyl-CoA desaturase-1 (SCD1) inhibitor, effectively suppresses delta-9 desaturase (Delta9D) activity in a dose-dependent manner, exhibiting an inhibition concentration (IC50) value of 0.9 µM [1]. Target: Others. Smiles: C(CCCCCCC(O)=O)C1=C(CCCCCCCC)C1
| Anwendung: | Cyclopropene fatty acid |
| CAS | 738-87-4 |
| MW: | 294.47 D |
1.320,00 €