Zu "K00254" wurden 106 Artikel gefunden!
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Leflunomide
Artikelnummer: Cay14860-25
Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of...
| Schlagworte: | Arava, HW 486, SU 101, 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide |
| Anwendung: | Immunosuppressant, pyrimidine synthesis inhibitor, dihydroorotate dehydrogenase inhibitor |
| CAS | 75706-12-6 |
| MW: | 270.2 D |
ab 49,00 €
Brequinar
Artikelnummer: Cay24445-1
Brequinar is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = ~20 nM), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. Brequinar is selective for DHODH over a panel of greater than 400 kinases at 100 nM. It induces differentiation of ER-HoxA9, U937, and THP-1 cells...
| Schlagworte: | NSC 368390, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid |
| Anwendung: | DHODH inhibitor |
| CAS | 96187-53-0 |
| MW: | 375.4 D |
ab 49,00 €
BAY-2402234
Artikelnummer: Cay33259-1
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 1.2 nM). It induces upregulation of the cell differentiation marker CD11b in MOLM-13 and HEL acute myeloid leukemia (AML) cells (EC50s = 3.16 and 0.96 nM, respectively) and inhibits the proliferation of nine leukemia cell lines (IC50s =...
| Schlagworte: | N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-5-fluoro-2-[(1S)-2,2,2-t... |
| Anwendung: | DHODH inhibitor |
| CAS | 2225819-06-5 |
| MW: | 520.8 D |
ab 145,00 €
Vidofludimus
Artikelnummer: Cay18377-10
Dihydroorotate dehydrogenase (DHODH) is involved in pyrimidine nucleoside biosynthesis. DHODH inhibitors have value in autoimmune diseases as well as cancer and certain infections. Vidofludimus is an immunosuppressive drug that inhibits DHODH (IC50s = 0.134, 1.29, and 10.6 µM for human, rat, and mouse isoforms,...
| Schlagworte: | 4SC-101, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid |
| Anwendung: | Dihydroorotate dehydrogenase (DHODH) inhibitor |
| CAS | 717824-30-1 |
| MW: | 355.4 D |
ab 56,00 €
A-771726
Artikelnummer: Cay14404-25
A-771726 is an active metabolite of the prodrug leflunomide (Cay-14860) that inhibits dihydroorotate dehydrogenase (DHODH, IC50 = 0.23 µM). A-771726 inhibits the production of prostaglandin E2 (PGE2, Cay-14010) in TNF-alpha- or IL-1alpha-stimulated isolated human synoviocytes (IC50s = 7 and 3 µM, respectively). It...
| Schlagworte: | Flucyamide, HMR 1726, SU 20, Teriflunomide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide |
| Anwendung: | Dihydroorotate dehydrogenase inhibitor, tyrosine kinase inhibitor |
| CAS | 163451-81-8 |
| MW: | 270.2 D |
ab 53,00 €
ASLAN003
Artikelnummer: Cay33516-10
ASLAN003 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 35 nM). It inhibits the proliferation of MOLM-14 and KG-1 acute myeloid leukemia (AML) cells (IC50s = 0.582 and 0.382 µM, respectively), as well as induces apoptosis in the same cells when used at concentrations of 0.5 and 1 µM. ASLAN003 (1, 2,...
| Schlagworte: | 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-3-pyridinecarboxylic acid |
| Anwendung: | DHODH inhibitor |
| CAS | 1035688-66-4 |
| MW: | 356.3 D |
ab 67,00 €
Leflunomide
Artikelnummer: LKT-L1817.1
Leflunomide is a pyrimidine biosynthesis inhibitor. It is an established disease-modifying antirheumatic drug. It has been approved for treatment of rheumatoid arthritis (RA) and may also be useful in treating patients with Felty´s syndrome. It is suggested that supression of TNF signalling is one of the...
| Schlagworte: | HWA-486 |
| Anwendung: | Pyrimidine biosynthesis inhibitor |
| CAS | 75706-12-6 |
| MW: | 270,21 D |
ab 141,00 €
ML-390
Artikelnummer: Cay21395-10
ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390...
| Schlagworte: | N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-benzamide |
| Anwendung: | DHODH inhibitor |
| CAS | 2029049-79-2 |
| MW: | 406.4 D |
ab 73,00 €
Leflunomide-d4
Artikelnummer: Cay26448-1
Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide (Cay-14860) by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T...
| Schlagworte: | 5-methyl-N-(4-(trifluoromethyl)phenyl-2,3,5,6-d4)isoxazole-4-carboxamide |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, dihydroorotate dehydrogenase inhibitor |
| CAS | 1189987-23-2 |
| MW: | 274.2 D |
ab 207,00 €
Anti-DHODH
Artikelnummer: ARG43427.50
Protein function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. [The UniProt Consortium]
| Schlagworte: | Anti-DHODH, Anti-DHOdehase, Anti-DHOdehase, Anti-Dihydroorotate oxidase, Anti-Dihydroorotate oxidase, Anti-Dihydroorotate... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
551,00 €
Anti-DHODH, clone 4E3
Artikelnummer: ARG43429.50
Protein function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. [The UniProt Consortium]
| Schlagworte: | Anti-DHODH, Anti-DHOdehase, Anti-DHOdehase, Anti-Dihydroorotate oxidase, Anti-Dihydroorotate oxidase, Anti-Dihydroorotate... |
| Anwendung: | FC, ICC, IF, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
551,00 €
Anti-DHODH
Artikelnummer: ATA-HPA010123.100
Protein function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 88% and to rat: 90%
| Schlagworte: | Anti-DHODH, Anti-DHOdehase, EC=1.3.5.2, Anti-Dihydroorotate oxidase, Anti-Dihydroorotate dehydrogenase (quinone),... |
| Anwendung: | WB, IHC, ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €