Zu "K00254" wurden 96 Artikel gefunden!
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Dihydroorotate dehydrogenase (quinone), mitochondrial...
Artikelnummer: CSB-EP714357RA1c2.1
Organism: Rattus norvegicus (Rat). Source: E.coli. Expression Region: 31-395aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-Trx-tagged. Target Protein Sequence: TGDDHFYAEY LMPGLQRLLD PESAHRLAVR VTSLGLLPRA TFQDSDMLEV KVLGHKFRNP VGIAAGFDKN GEAVDGLYKL GFGFVEVGSV TPQPQEGNPR PRVFRLPEDQ AVINRYGFNS HGLSVVEHRL...
| Schlagworte: | Dhodh, DHOdehase, Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | rat |
| MW: | 57.6 kD |
ab 364,00 €
PTC299
Artikelnummer: TGM-T12574-100mg
Description: PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydrolactate...
| Schlagworte: | Emvododstat, (4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate |
| Anwendung: | Targets vascular endothelial growth factor A (VEGFA) |
| CAS | 1256565-36-2 |
| MW: | 467.34 D |
ab 119,00 €
PfDHODH-IN-1
Artikelnummer: TGM-T12438-100mg
Description: PfDHODH-IN-1, an analogue of the active Leflunomide metabolite, exhibits antimalarial activity. Target: Parasite, Dehydrogenase. Smiles: O\C(C1CC1)=C(\C#N)C(=O)Nc1ccc(cc1)C(F)(F)F. References: Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active...
| Anwendung: | DHODH inhibitor |
| CAS | 183945-55-3 |
| MW: | 296.24 D |
ab 67,00 €
ML390
Artikelnummer: TGM-T13774-100mg
Description: ML390 exerts its potent differentiation effect on multiple leukemia models. Target: Dehydrogenase, Others. Smiles: FC(F)(F)Oc1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12. References: Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National...
| Anwendung: | DHODH inhibitor |
| CAS | 2029049-79-2 |
| MW: | 406.4 D |
ab 42,00 €
BAY-2402234
Artikelnummer: TGM-T14501-100mg
Description: BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. Target: Dehydrogenase, DNA/RNA Synthesis. Smiles:...
| Anwendung: | DHODH inhibitor |
| CAS | 2225819-06-5 |
| MW: | 520.84 D |
ab 181,00 €
DSM265
Artikelnummer: TGM-T15173-10mg
Description: DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections. Target: Parasite, Dehydrogenase. Smiles:...
| Schlagworte: | PfSPZ |
| Anwendung: | Antimalarial agent |
| CAS | 1282041-94-4 |
| MW: | 415.33 D |
ab 31,00 €
Olorofim
Artikelnummer: TGM-T27300-1mg
Description: Olorofim is a novel selective antifungal compound with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM) and almost no inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against various pathogenic filamentous and dimorphic fungi such as Penicillium spp, Dermatophilus spp...
| Schlagworte: | Olorofim, F901318, F-901318 |
| Anwendung: | Targets dihydroorotate dehydrogenase [EC:1.3.5.2] (DHODH, pyrD) |
| CAS | 1928707-56-5 |
| MW: | 498.55 D |
ab 389,00 €
Brequinar
Artikelnummer: TGM-T5013-100mg
Description: Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses. Target: Dehydrogenase, DNA/RNA Synthesis, Virus Protease. Smiles: Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F. References: Qing M, et al. Characterization of...
| Schlagworte: | Bipenquinate, NSC 368390, DUP785 |
| Anwendung: | DHODH inhibitor |
| CAS | 96187-53-0 |
| MW: | 375.37 D |
ab 42,00 €
Teriflunomide
Artikelnummer: TGM-T7534-100mg
Description: Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis. Target: Others. Smiles: C(F)(F)(F)C1=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C1. References: Paul O , Oh . An update of teriflunomide for treatment of multiple...
| Schlagworte: | A 77-1726 |
| Anwendung: | Targets dihydroorotate dehydrogenase [EC:1.3.5.2] (DHODH, pyrD) |
| CAS | 163451-81-8 |
| MW: | 270.21 D |
ab 45,00 €
Bipenquinate
Artikelnummer: TGM-T8332-100mg
Description: Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis. Target: Dehydrogenase. Smiles: [Na+].Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c1ccc(cc1)-c1ccccc1F. References: Li S F , Gong M J , Sun Y F , et al. Antiviral...
| Anwendung: | Targets dihydroorotate dehydrogenase [EC:1.3.5.2] (DHODH, pyrD) |
| CAS | 96201-88-6 |
| MW: | 397.36 D |
ab 31,00 €
AG-636
Artikelnummer: TGM-T9121-100mg
Description: AG-636 is a potent, reversible, and selective DHODH inhibitor with an IC50 of 17 nM and is orally active. It demonstrates strong anticancer effects. Target: DNA/RNA Synthesis, Dehydrogenase. Smiles: Cc1ccccc1-c1ccc(cc1)-c1cc(C(O)=O)c2n(C)nnc2c1. References: Gabrielle McDonald, et al. Selective...
| Anwendung: | DHODH inhibitor |
| CAS | 1623416-31-8 |
| MW: | 343.38 D |
ab 67,00 €
DHODH Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01225-100ug
Description: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
| Schlagworte: | Dihydroorotate dehydrogenase (quinone), mitochondrial, DHODH, Dihydroorotate oxidase, DHOdehase |
| MW: | 45.1 kD |
ab 198,00 €