Zu "K00031" wurden 185 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
(2R)-Octyl-alpha-hydroxyglutarate
Artikelnummer: Cay16366-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Schlagworte: | (2R)-Octyl-2-HG, 2R-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-67-4 |
| MW: | 260.3 D |
ab 40,00 €
Anti-IDH1
Artikelnummer: ABS-KC-3956.100
| Schlagworte: | Anti-Isocitrate dehydrogenase [NADP] cytoplasmic, Anti-IDH, Anti-IDH1, Anti-Cytosolic NADP-isocitrate dehydrogenase,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
IDH1(R132H) Assay Kit
Artikelnummer: BPS-79376
The IDH1(R132H) Assay Kit is designed to measure IDH1(R132H) activity for screening and profiling applications by measuring NADPH consumption.
| Schlagworte: | Isocitrate Dehydrogenase 1, IDH1, Oxalosuccinate Decarboxylase, IDHM, |
| Anwendung: | Drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
IDH1 Inhibitor 5
Artikelnummer: TGM-T62725-100mg
Description: IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor with an IC50 of 64.4 nM for MOG cells and an IC50 of 34.9 nM for wild-type IDH1 glioma cells expressing exogenous mutant IDH1 R132H protein. Target: Others. Smiles:...
| Anwendung: | IDH1 inhibitor |
| CAS | 1940128-37-9 |
| MW: | 450.57 D |
ab 2.142,00 €
IDH1 Inhibitor 7
Artikelnummer: TGM-T72705-100mg
Description: IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM . Target: Others. Smiles: [C@@H](C)(C)[C@@H]1N(C2=NC(N[C@@H](C)C3=CN(C=N3)C4=CC=C(C(F)(F)F)C=C4)=NC=C2)C(=O)NC1
| Anwendung: | IDH1 inhibitor |
| CAS | 2135309-56-5 |
| MW: | 459.47 D |
ab 1.419,00 €
DS-1001b
Artikelnummer: TGM-T7741-100mg
Description: DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1). Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH). Smiles: CC(C)(C)N.Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12. References: Yoshiki A , Yohei M , Toshihiko W , et al. ACT-14 A FIRST-IN-HUMAN STUDY OF...
| Anwendung: | Mutant IDH1 inhibitor |
| CAS | 1898207-64-1 |
| MW: | 608.92 D |
ab 31,00 €
Vorasidenib
Artikelnummer: TGM-T7307-100mg
Description: Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH, IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively). Target: Isocitrate Dehydrogenase (IDH). Smiles: C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F. References: Zakkula A, Dittakavi S, Maniyar...
| Schlagworte: | AG-881, PVM/MA |
| Anwendung: | Targets isocitrate dehydrogenase [EC:1.1.1.42] (IDH1, IDH2, icd) |
| CAS | 1644545-52-7 |
| MW: | 414.74 D |
ab 48,00 €
Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant...
Artikelnummer: TGM-TMPY-02413-1mg
Description: Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 48 kDa and the accession number is O75874.
| Schlagworte: | HEL-S-26, IDCD, HEL-216, IDP, PICD, isocitrate dehydrogenase 1 (NADP+), soluble, IDH, IDPC |
| MW: | 48 kD |
ab 699,00 €
BAY-1436032
Artikelnummer: TGM-TQ0042-10mg
Description: BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1). Target: Isocitrate Dehydrogenase (IDH), Dehydrogenase. Smiles: C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12. References: Chaturvedi A, et al. Pan-mutant-IDH1...
| Anwendung: | Mutant IDH1 inhibitor |
| CAS | 1803274-65-8 |
| MW: | 489.53 D |
ab 31,00 €
AGI-6780
Artikelnummer: TGM-T1809-100mg
Description: AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant. Target: Isocitrate Dehydrogenase (IDH), Dehydrogenase. Smiles: FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)S(=O)(=O)NC2CC2)c1. References: Wang F, et al. Science. 2013, 340(6132), 622-666.
| Anwendung: | Mutant IDH2 inhibitor |
| CAS | 1432660-47-3 |
| MW: | 481.51 D |
ab 31,00 €
(S,R)-WT IDH1 Inhibitor 2
Artikelnummer: TGM-T63402-10mg
Description: (S,R)-WT IDH1 Inhibitor 2 is a selective and potent mutant IDH1 inhibitor that inhibits R132G (IC50: 2.9 nM), R132C (IC50: 3.8 nM), R132H (IC50: 4.6 nM) and WT IDH1 (IC50: 46 nM) with 100-fold higher selectivity than IDH2. 100-fold higher selectivity than IDH2. (S,R)-WT IDH1 Inhibitor 2 is investigated...
| Anwendung: | IDH1 inhibitor |
| CAS | 1816272-18-0 |
| MW: | 501.55 D |
ab 994,00 €
WT IDH1 Inhibitor 2
Artikelnummer: TGM-T63403-10mg
Description: WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor (IC50: 120 nM) and is a mutant R132H IDH1 inhibitor, an isoform of GSK321 with wild-type cross-reactivity. Target: Others. Smiles: C[C@@H](O)c1cccc(NC(=O)c2nn(Cc3ccc(F)cc3)c3[C@H](C)CN(Cc23)C(=O)c2ccc[nH]2)c1
| Anwendung: | WT IDH1 inhibitor |
| CAS | 1816272-19-1 |
| MW: | 501.55 D |
ab 996,00 €