Zu "K00031" wurden 218 Artikel gefunden!
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(2R)-Octyl-alpha-hydroxyglutarate
Artikelnummer: Cay16366-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Schlagworte: | (2R)-Octyl-2-HG, 2R-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-67-4 |
| MW: | 260.3 D |
ab 53,00 €
IDH1(R132H) Assay Kit
Artikelnummer: BPS-79376
The IDH1(R132H) Assay Kit is designed to measure IDH1(R132H) activity for screening and profiling applications by measuring NADPH consumption.
| Schlagworte: | Isocitrate Dehydrogenase 1, IDH1, Oxalosuccinate Decarboxylase, IDHM, |
| Anwendung: | Drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
IDH1, His, Human
Artikelnummer: GSC-Z05396-100
Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of alpha -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of...
| Schlagworte: | IDPc, IDH1, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, Cytosolic NADP-isocitrate dehydrogenase, Isocitrate... |
| Ursprungsart: | human |
| MW: | 47.35 kD |
ab 457,00 €
Anti-IDH2 (R172K)
Artikelnummer: NB-26163
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Isocitrate dehydrogenase (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. The isocitrate and isopropylmalate dehydrogenases family has three members, IDH1, IDH2 and IDH3. IDH2 plays a role in intermediary...
| Schlagworte: | Anti-IDP, Anti-IDH, Anti-IDH2, Anti-ICD-M, EC=1.1.1.42, Anti-NADP(+)-specific ICDH, Anti-Oxalosuccinate decarboxylase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | vertebrates |
746,00 €
AG-120
Artikelnummer: Cay19894-10
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.Formal Name:...
| Schlagworte: | Invosidenib,... |
| Anwendung: | IDH1 inhibitor |
| CAS | 1448347-49-6 |
| MW: | 583 D |
ab 49,00 €
ML-309 (hydrochloride)
Artikelnummer: Cay21519-10
ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM).Formal Name:...
| Schlagworte: | N-[2-(cyclopentylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-1H-benzimidazole-1-acetamide, monohydrochloride |
| Anwendung: | IDH1 (R132H mutant ) inhibitor |
| CAS | 1355327-02-4 |
| MW: | 521 D |
ab 58,00 €
AGI-5198
Artikelnummer: Cay14624-1
Isocitrate dehydrogenases (IDHs) are nicotinamide adenine dinucleotide (NAD+) and NAD phosphate (NADP+)-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing a-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade...
| Schlagworte: | N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide |
| Anwendung: | Inhibitor of IDH1 R132H and R132C mutants |
| CAS | 1355326-35-0 |
| MW: | 462.6 D |
ab 139,00 €
IDH2 Human Recombinant Protein, FLAG-tag
Artikelnummer: BPS-71074-1
Human isocitrate dehydrogenase 2, also known as IDH2, (GenBank Accession No. NM_002168), a.a. 1-452(end)) with C-terminal Flag-tag, MW = 52 kDa, expressed in a baculovirus infected Sf9 cell expression system.
| Schlagworte: | IDH, IDP, IDH2, ICD-M, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, Isocitrate dehydrogenase [NADP], mitochondrial, |
| Anwendung: | Enzyme kinetics, screening inhibitors, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 52 kD |
ab 438,00 €
Enasidenib
Artikelnummer: Cay21277-10
Enasidenib is an inhibitor of mutant isocitrate dehydrogenase 2 (IDH2, IC50 = 0.1 µM for IDH2 R140Q). It is selective for IDH2 R140Q over wild-type IDH2, wild-type IDH1, and IDH1 R132H (IC50s = 1.8, 0.45, and 48.4 µM, respectively). Enasidenib (0.1, 1, and 5 µM) inhibits production of D-2-hydroxyglutarate...
| Schlagworte: | AG-221, CC-90007,... |
| Anwendung: | Allosteric IDH2 inhibitor |
| CAS | 1446502-11-9 |
| MW: | 473.4 D |
ab 75,00 €
AGI-6780
Artikelnummer: Cay14639-1
Isocitrate dehydrogenases (IDHs) are NAD+ and NADP+-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing alpha-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade gliomas. The most common mutations map to arginine...
| Schlagworte: | N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide |
| Anwendung: | Mutant IDH2 inhibitor |
| CAS | 1432660-47-3 |
| MW: | 481.5 D |
ab 67,00 €
(2R)-Octyl-alpha-hydroxyglutarate-d17
Artikelnummer: Cay19694-5
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Schlagworte: | (2R)-Octyl-2-HG-d17, 2R-hydroxy-pentanedioic acid, 1-octyl-d17 ester |
| Anwendung: | Cell-permeable D-2-HG derivative |
| CAS | 2748638-78-8 |
| MW: | 277.4 D |
ab 112,00 €
TFMB-R-2-HG
Artikelnummer: Cay20461-1
TFMB-R-2-HG is a cell-permeable form of (R)-2-hydroxyglutarate ((R)-2-HG). (R)-2-HG is structurally similar to alpha-ketoglutarate and competitively inhibits alpha-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. TFMB-R-2-HG has been used to assess the role of (R)-2-HG in...
| Schlagworte: | (2R)-tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester |
| Anwendung: | Cell-permeable leukemogenesis promoter |
| CAS | 1445700-01-5 |
| MW: | 288.2 D |
ab 93,00 €