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Zu "K00031" wurden 146 Artikel gefunden!
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Artikelnummer: Cay16366-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
Schlagworte: | (2R)-Octyl-2-HG, 2R-hydroxy-pentanedioic acid, 1-octyl ester |
CAS | 1391194-67-4 |
MW: | 260.3 D |
ab 73,00 €
Artikelnummer: E-BC-K554-M.96
Detection principle: Isocitrate dehydrogenase converts isocitrate to alpha- ketoglutaric acid, while converting NADP+ to NADPH. Under the action of electron coupling agents, the generated NADPH has a characteristic absorption peak at 450 nm. The activity of NADP-IDH can be calculated by measuring the change of...
Schlagworte: | IDH, PICD, IDPc, IDH1, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, Cytosolic NADP-isocitrate dehydrogenase,... |
416,00 €
Artikelnummer: ELK-ELK8675.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ICD. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ICD. Next,...
Schlagworte: | IDH, IDH1, IDPc, PICD, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, Cytosolic NADP-isocitrate dehydrogenase,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK4452.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IDH2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human IDH2. Next,...
Schlagworte: | IDH, IDP, IDH2, ICD-M, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, Isocitrate dehydrogenase [NADP], mitochondrial |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: BPS-79376
The IDH1(R132H) Assay Kit is designed to measure IDH1(R132H) activity for screening and profiling applications by measuring NADPH consumption.
Schlagworte: | Isocitrate Dehydrogenase 1, IDH1, Oxalosuccinate Decarboxylase, IDHM, |
Anwendung: | Drug discovery, HTS |
Spezies-Reaktivität: | human |
789,00 €
Artikelnummer: NB-26163
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Isocitrate dehydrogenase (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. The isocitrate and isopropylmalate dehydrogenases family has three members, IDH1, IDH2 and IDH3. IDH2 plays a role in intermediary...
Schlagworte: | Anti-IDP, Anti-IDH, Anti-IDH2, Anti-ICD-M, EC=1.1.1.42, Anti-NADP(+)-specific ICDH, Anti-Oxalosuccinate decarboxylase,... |
Anwendung: | ELISA, WB, IHC |
Wirt: | Mouse |
Spezies-Reaktivität: | vertebrates |
717,00 €
Artikelnummer: Cay19894-10
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.Formal Name:...
Schlagworte: | Invosidenib,... |
Anwendung: | IDH1 inhibitor |
CAS | 1448347-49-6 |
MW: | 583 D |
ab 43,00 €
Artikelnummer: Cay14624-1
Isocitrate dehydrogenases (IDHs) are nicotinamide adenine dinucleotide (NAD+) and NAD phosphate (NADP+)-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing a-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade...
Schlagworte: | N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide |
Anwendung: | Inhibitor of IDH1 R132H and R132C mutants |
CAS | 1355326-35-0 |
MW: | 462.6 D |
ab 125,00 €
Artikelnummer: Cay21519-10
ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM).Formal Name:...
Schlagworte: | N-[2-(cyclopentylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-1H-benzimidazole-1-acetamide, monohydrochloride |
Anwendung: | IDH1 (R132H mutant ) inhibitor |
CAS | 1355327-02-4 |
MW: | 521 D |
ab 53,00 €
Artikelnummer: Cay14639-1
Isocitrate dehydrogenases (IDHs) are NAD+ and NADP+-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing alpha-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade gliomas. The most common mutations map to arginine...
Schlagworte: | N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide |
Anwendung: | Mutant IDH2 inhibitor |
CAS | 1432660-47-3 |
MW: | 481.5 D |
ab 60,00 €
Artikelnummer: Cay19694-5
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
Schlagworte: | (2R)-Octyl-2-HG-d17, 2R-hydroxy-pentanedioic acid, 1-octyl-d17 ester |
Anwendung: | Cell-permeable D-2-HG derivative |
CAS | 2748638-78-8 |
MW: | 277.4 D |
ab 92,00 €
Artikelnummer: Cay21277-10
Enasidenib is an inhibitor of mutant isocitrate dehydrogenase 2 (IDH2, IC50 = 0.1 µM for IDH2 R140Q). It is selective for IDH2 R140Q over wild-type IDH2, wild-type IDH1, and IDH1 R132H (IC50s = 1.8, 0.45, and 48.4 µM, respectively). Enasidenib (0.1, 1, and 5 µM) inhibits production of D-2-hydroxyglutarate...
Schlagworte: | AG-221, CC-90007,... |
Anwendung: | Allosteric IDH2 inhibitor |
CAS | 1446502-11-9 |
MW: | 473.4 D |
ab 130,00 €