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Irinotecan
Artikelnummer: TGM-T6228-10mg
Description: Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death. Target: Topoisomerase, Autophagy....
| Schlagworte: | CPT-11, Topotecin, (+)-Irinotecan |
| Anwendung: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 97682-44-5 |
| MW: | 586.68 D |
ab 30,00 €
Irinotecan
Artikelnummer: LKT-I6932.10
Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore...
| Schlagworte: | CPT-11 |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 97682-44-5 |
| MW: | 586,68 D |
ab 94,00 €
