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PF-04217903
Artikelnummer: Cay17931-1
PF-04217903 is an inhibitor of c-Met (Ki = 4.8 nM). It is greater than 1,000-fold selective for c-Met over a panel of 150 kinases. PF-04217903 inhibits the proliferation of and induces apoptosis in GTL-16 gastric carcinoma cells (IC50s = 12 and 31 nM, respectively) as well as inhibits migration of NCI H441 lung...
| Schlagworte: | 4-[1-(6-quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol |
| Anwendung: | c-Met kinase inhibitor |
| CAS | 956905-27-4 |
| MW: | 372.4 D |
ab 67,00 €
PF-04217903
Artikelnummer: SYN-1060-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM. Target: MET , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | PF04217903 |
| Anwendung: | MET inhibitor |
| CAS | 956905-27-4 |
| MW: | 372,4 D |
ab 92,00 €
